6KHE
Crystal structure of CLK2 in complex with CX-4945
Summary for 6KHE
Entry DOI | 10.2210/pdb6khe/pdb |
Descriptor | Dual specificity protein kinase CLK2, 5-[(3-chlorophenyl)amino]benzo[c][2,6]naphthyridine-8-carboxylic acid (3 entities in total) |
Functional Keywords | cdc2-like kinase, casein kinase, cx-4945, alternative splicing, splicing, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 60562.16 |
Authors | Lee, J.Y.,Yun, J.S.,Jin, H.,Chang, J.H. (deposition date: 2019-07-15, release date: 2019-10-02, Last modification date: 2024-03-27) |
Primary citation | Lee, J.Y.,Yun, J.S.,Kim, W.K.,Chun, H.S.,Jin, H.,Cho, S.,Chang, J.H. Structural Basis for the Selective Inhibition of Cdc2-Like Kinases by CX-4945. Biomed Res Int, 2019:6125068-6125068, 2019 Cited by PubMed: 31531359DOI: 10.1155/2019/6125068 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
Download full validation report