5FTA
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![BU of 5fta by Molmil](/molmil-images/mine/5fta) | Crystal structure of the N-terminal BTB domain of human KCTD10 | Descriptor: | BTB/POZ DOMAIN-CONTAINING ADAPTER FOR CUL3-MEDIATED RHOA DEGRADATION PROTEIN 3, MERCURY (II) ION | Authors: | Pinkas, D.M, Sanvitale, C.E, Solcan, N, Goubin, S, Tallant, C, Newman, J.A, Kopec, J, Fitzpatrick, F, Talon, R, Collins, P, Krojer, T, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Bullock, A. | Deposit date: | 2016-01-12 | Release date: | 2016-02-17 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.64 Å) | Cite: | Structural complexity in the KCTD family of Cullin3-dependent E3 ubiquitin ligases. Biochem. J., 474, 2017
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2I0H
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![BU of 2i0h by Molmil](/molmil-images/mine/2i0h) | The structure of p38alpha in complex with an arylpyridazinone | Descriptor: | 2-(3-{(2-CHLORO-4-FLUOROPHENYL)[1-(2-CHLOROPHENYL)-6-OXO-1,6-DIHYDROPYRIDAZIN-3-YL]AMINO}PROPYL)-1H-ISOINDOLE-1,3(2H)-DIONE, GLYCEROL, Mitogen-activated protein kinase 14 | Authors: | Natarajan, S.R, Heller, S.T, Nam, K, Singh, S.B, Scapin, G, Patel, S, Thompson, J.E, Fitzgerald, C.E, O'Keefe, S.J. | Deposit date: | 2006-08-10 | Release date: | 2006-10-17 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | p38 MAP Kinase Inhibitors Part 6: 2-Arylpyridazin-3-ones as templates for inhibitor design. Bioorg.Med.Chem.Lett., 16, 2006
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5F92
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![BU of 5f92 by Molmil](/molmil-images/mine/5f92) | Fumarate hydratase of Mycobacterium tuberculosis in complex with formate | Descriptor: | CHLORIDE ION, FORMIC ACID, Fumarate hydratase class II, ... | Authors: | Kasbekar, M, Fischer, G, Mott, B.T, Yasgar, A, Hyvonen, M, Boshoff, H.I, Abell, C, Barry, C.E, Thomas, C.J. | Deposit date: | 2015-12-09 | Release date: | 2016-06-22 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (1.859 Å) | Cite: | Selective small molecule inhibitor of the Mycobacterium tuberculosis fumarate hydratase reveals an allosteric regulatory site. Proc.Natl.Acad.Sci.USA, 113, 2016
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5FFX
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5FJQ
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![BU of 5fjq by Molmil](/molmil-images/mine/5fjq) | Structural and functional analysis of a lytic polysaccharide monooxygenase important for efficient utilization of chitin in Cellvibrio japonicus | Descriptor: | CARBOHYDRATE BINDING PROTEIN, PUTATIVE, CPB33A, ... | Authors: | Forsberg, Z, Nelson, C.E, Dalhus, B, Mekasha, S, Loose, J.S.M, Rohr, A.K, Eijsink, V.G.H, Gardner, J.G, Vaaje-Kolstad, G. | Deposit date: | 2015-10-12 | Release date: | 2016-02-17 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Structural and Functional Analysis of a Lytic Polysaccharide Monooxygenase Important for Efficient Utilization of Chitin in Cellvibrio Japonicus J.Biol.Chem., 291, 2016
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2H7V
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![BU of 2h7v by Molmil](/molmil-images/mine/2h7v) | Co-crystal structure of YpkA-Rac1 | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Migration-inducing protein 5, ... | Authors: | Prehna, G, Ivanov, M, Bliska, J.B, Stebbins, C.E. | Deposit date: | 2006-06-04 | Release date: | 2006-09-19 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Yersinia virulence depends on mimicry of host rho-family nucleotide dissociation inhibitors. Cell(Cambridge,Mass.), 126, 2006
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2HFN
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![BU of 2hfn by Molmil](/molmil-images/mine/2hfn) | Crystal Structures of the Synechocystis Photoreceptor Slr1694 Reveal Distinct Structural States Related to Signaling | Descriptor: | FLAVIN MONONUCLEOTIDE, Synechocystis Photoreceptor (Slr1694) | Authors: | Yuan, H, Anderson, S, Masuda, S, Dragnea, V, Moffat, K, Bauer, C.E. | Deposit date: | 2006-06-24 | Release date: | 2006-12-19 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Crystal structures of the Synechocystis photoreceptor Slr1694 reveal distinct structural states related to signaling. Biochemistry, 45, 2006
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5FFZ
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4Y95
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![BU of 4y95 by Molmil](/molmil-images/mine/4y95) | Crystal structure of the kinase domain of Bruton's tyrosine kinase with mutations in the activation loop | Descriptor: | 2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, 4-tert-butyl-N-[2-methyl-3-(4-methyl-6-{[4-(morpholin-4-ylcarbonyl)phenyl]amino}-5-oxo-4,5-dihydropyrazin-2-yl)phenyl]benzamide, BETA-MERCAPTOETHANOL, ... | Authors: | Wang, Q, Rosen, C.E, Kuriyan, J. | Deposit date: | 2015-02-16 | Release date: | 2015-03-18 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.599 Å) | Cite: | Autoinhibition of Bruton's tyrosine kinase (Btk) and activation by soluble inositol hexakisphosphate. Elife, 4, 2015
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5E54
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![BU of 5e54 by Molmil](/molmil-images/mine/5e54) | Two apo structures of the adenine riboswitch aptamer domain determined using an X-ray free electron laser | Descriptor: | MAGNESIUM ION, Vibrio vulnificus strain 93U204 chromosome II, adenine riboswitch aptamer domain | Authors: | Stagno, J.R, Wang, Y.-X, Liu, Y, Bhandari, Y.R, Conrad, C.E, Nelson, G, Li, C, Wendel, D.R, White, T.A, Barty, A, Tuckey, R.A, Zatsepin, N.A, Grant, T.D, Fromme, P, Tan, K, Ji, X, Spence, J.C.H. | Deposit date: | 2015-10-07 | Release date: | 2016-11-23 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structures of riboswitch RNA reaction states by mix-and-inject XFEL serial crystallography. Nature, 541, 2017
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2H7O
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![BU of 2h7o by Molmil](/molmil-images/mine/2h7o) | Crystal structure of the Rho-GTPase binding domain of YpkA | Descriptor: | Protein kinase ypkA | Authors: | Prehna, G, Ivanov, M, Bliska, J.B, Stebbins, C.E. | Deposit date: | 2006-06-02 | Release date: | 2006-09-19 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Yersinia virulence depends on mimicry of host rho-family nucleotide dissociation inhibitors. Cell(Cambridge,Mass.), 126, 2006
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5J8C
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![BU of 5j8c by Molmil](/molmil-images/mine/5j8c) | Human MOF C316S, E350Q crystal structure | Descriptor: | CHLORIDE ION, Histone acetyltransferase KAT8, SODIUM ION, ... | Authors: | McCullough, C.E, Marmorstein, R. | Deposit date: | 2016-04-07 | Release date: | 2016-07-20 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.17 Å) | Cite: | Structural and Functional Role of Acetyltransferase hMOF K274 Autoacetylation. J.Biol.Chem., 291, 2016
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5J8F
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![BU of 5j8f by Molmil](/molmil-images/mine/5j8f) | Human MOF K274P crystal structure | Descriptor: | CHLORIDE ION, Histone acetyltransferase KAT8, ZINC ION | Authors: | McCullough, C.E, Marmorstein, R. | Deposit date: | 2016-04-07 | Release date: | 2016-07-20 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structural and Functional Role of Acetyltransferase hMOF K274 Autoacetylation. J.Biol.Chem., 291, 2016
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2GWM
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5G3Q
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![BU of 5g3q by Molmil](/molmil-images/mine/5g3q) | Crystal structure of a hypothetical domain in WNK1 | Descriptor: | WNK1 | Authors: | Pinkas, D.M, Bufton, J.C, Sanvitale, C.E, Bartual, S.G, Adamson, R.J, Krojer, T, Burgess-Brown, N.A, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Bullock, A. | Deposit date: | 2016-04-29 | Release date: | 2017-05-31 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (1.613 Å) | Cite: | Crystal Structure of a Hypothetical Domain in Wnk1 To be Published
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5E6Q
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![BU of 5e6q by Molmil](/molmil-images/mine/5e6q) | Importin alpha binding to XRCC1 NLS peptide | Descriptor: | CHLORIDE ION, DNA repair protein XRCC1 NLS peptide, GLYCEROL, ... | Authors: | Pedersen, L.C, Kirby, T.W, Gassman, N.R, Smith, C.E, Gabel, S.A, Sobhany, M, Wilson, S.H, London, R.E. | Deposit date: | 2015-10-10 | Release date: | 2015-10-28 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.305 Å) | Cite: | Nuclear Localization of the DNA Repair Scaffold XRCC1: Uncovering the Functional Role of a Bipartite NLS. Sci Rep, 5, 2015
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4YFX
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![BU of 4yfx by Molmil](/molmil-images/mine/4yfx) | Escherichia coli RNA polymerase in complex with Myxopyronin B | Descriptor: | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... | Authors: | Molodtsov, V, Fleming, P.R, Eyermann, C.J, Ferguson, A.D, Foulk, M.A, McKinney, D.C, Masse, C.E, Buurman, E.T, Murakami, K.S. | Deposit date: | 2015-02-25 | Release date: | 2015-03-11 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (3.844 Å) | Cite: | X-ray Crystal Structures of Escherichia coli RNA Polymerase with Switch Region Binding Inhibitors Enable Rational Design of Squaramides with an Improved Fraction Unbound to Human Plasma Protein. J.Med.Chem., 58, 2015
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4YX5
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![BU of 4yx5 by Molmil](/molmil-images/mine/4yx5) | SpaO(SPOA1,2) | Descriptor: | CHLORIDE ION, Surface presentation of antigens protein SpaO | Authors: | Notti, R.Q, Stebbins, C.E. | Deposit date: | 2015-03-22 | Release date: | 2015-06-03 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.9001 Å) | Cite: | A common assembly module in injectisome and flagellar type III secretion sorting platforms. Nat Commun, 6, 2015
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4YFK
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![BU of 4yfk by Molmil](/molmil-images/mine/4yfk) | Escherichia coli RNA polymerase in complex with squaramide compound 8. | Descriptor: | 3,5-dimethyl-N-{2-[4-(4-methylbenzyl)piperidin-1-yl]-3,4-dioxocyclobut-1-en-1-yl}-1,2-oxazole-4-sulfonamide, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... | Authors: | Molodtsov, V, Fleming, P.R, Eyermann, C.J, Ferguson, A.D, Foulk, M.A, McKinney, D.C, Masse, C.E, Buurman, E.T, Murakami, K.S. | Deposit date: | 2015-02-25 | Release date: | 2015-03-11 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (3.571 Å) | Cite: | X-ray Crystal Structures of Escherichia coli RNA Polymerase with Switch Region Binding Inhibitors Enable Rational Design of Squaramides with an Improved Fraction Unbound to Human Plasma Protein. J.Med.Chem., 58, 2015
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4YFN
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![BU of 4yfn by Molmil](/molmil-images/mine/4yfn) | Escherichia coli RNA polymerase in complex with squaramide compound 14 (N-[3,4-dioxo-2-(4-{[4-(trifluoromethyl)benzyl]amino}piperidin-1-yl)cyclobut-1-en-1-yl]-3,5-dimethyl-1,2-oxazole-4-sulfonamide) | Descriptor: | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... | Authors: | Molodtsov, V, Fleming, P.R, Eyermann, C.J, Ferguson, A.D, Foulk, M.A, McKinney, D.C, Masse, C.E, Buurman, E.T, Murakami, K.S. | Deposit date: | 2015-02-25 | Release date: | 2015-03-11 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (3.817 Å) | Cite: | X-ray Crystal Structures of Escherichia coli RNA Polymerase with Switch Region Binding Inhibitors Enable Rational Design of Squaramides with an Improved Fraction Unbound to Human Plasma Protein. J.Med.Chem., 58, 2015
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5FB2
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4YX1
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![BU of 4yx1 by Molmil](/molmil-images/mine/4yx1) | SpaO(SPOA2) | Descriptor: | CALCIUM ION, Surface presentation of antigens protein SpaO | Authors: | Notti, R.Q, Stebbins, C.E. | Deposit date: | 2015-03-21 | Release date: | 2015-06-03 | Last modified: | 2017-11-22 | Method: | X-RAY DIFFRACTION (1.35 Å) | Cite: | A common assembly module in injectisome and flagellar type III secretion sorting platforms. Nat Commun, 6, 2015
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2KQA
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![BU of 2kqa by Molmil](/molmil-images/mine/2kqa) | The solution structure of the fungal elicitor Cerato-Platanin | Descriptor: | Cerato-platanin | Authors: | Oliveira, A.L, Gallo, M, Pazzagli, L, Cappugi, G, Scala, A, Cicero, D.O, Pantera, B, Spisni, A, Benedetti, C.E, Pertinhez, T.A. | Deposit date: | 2009-11-03 | Release date: | 2011-03-23 | Last modified: | 2011-07-13 | Method: | SOLUTION NMR | Cite: | The solution structure of the fungal elicitor Cerato-Platanin To be Published
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4YX7
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4YXC
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![BU of 4yxc by Molmil](/molmil-images/mine/4yxc) | |