4YX1
SpaO(SPOA2)
Summary for 4YX1
| Entry DOI | 10.2210/pdb4yx1/pdb |
| Descriptor | Surface presentation of antigens protein SpaO, CALCIUM ION (3 entities in total) |
| Functional Keywords | type iii secretion system, protein transport |
| Biological source | Salmonella typhimurium |
| Total number of polymer chains | 2 |
| Total formula weight | 15783.14 |
| Authors | Notti, R.Q.,Stebbins, C.E. (deposition date: 2015-03-21, release date: 2015-06-03, Last modification date: 2024-11-20) |
| Primary citation | Notti, R.Q.,Bhattacharya, S.,Lilic, M.,Stebbins, C.E. A common assembly module in injectisome and flagellar type III secretion sorting platforms. Nat Commun, 6:7125-7125, 2015 Cited by PubMed Abstract: Translocating proteins across the double membrane of Gram-negative bacteria, type III secretion systems (T3SS) occur in two evolutionarily related forms: injectisomes, delivering virulence factors into host cells, and the flagellar system, secreting the polymeric filament used for motility. While both systems share related elements of a cytoplasmic sorting platform that facilitates the hierarchical secretion of protein substrates, its assembly and regulation remain unclear. Here we describe a module mediating the assembly of the sorting platform in both secretion systems, and elucidate the structural basis for segregation of homologous components among these divergent T3SS subtypes sharing a common cytoplasmic milieu. These results provide a foundation for the subtype-specific assembly of T3SS sorting platforms and will support further mechanistic analysis and anti-virulence drug design. PubMed: 25994170DOI: 10.1038/ncomms8125 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.35 Å) |
Structure validation
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