4Y95

Crystal structure of the kinase domain of Bruton's tyrosine kinase with mutations in the activation loop

Summary for 4Y95

Entry DOI	10.2210/pdb4y95/pdb
Related	4Y93 4Y94
Descriptor	Non-specific protein-tyrosine kinase, 4-tert-butyl-N-[2-methyl-3-(4-methyl-6-{[4-(morpholin-4-ylcarbonyl)phenyl]amino}-5-oxo-4,5-dihydropyrazin-2-yl)phenyl]benzamide, GLYCEROL, ... (6 entities in total)
Functional Keywords	btk, kinase domain, transferase
Biological source	Bos taurus (Bovine)
Total number of polymer chains	4
Total formula weight	128177.75
Authors	Wang, Q.,Rosen, C.E.,Kuriyan, J. (deposition date: 2015-02-16, release date: 2015-03-18, Last modification date: 2024-02-28)
Primary citation	Wang, Q.,Vogan, E.M.,Nocka, L.M.,Rosen, C.E.,Zorn, J.A.,Harrison, S.C.,Kuriyan, J. Autoinhibition of Bruton's tyrosine kinase (Btk) and activation by soluble inositol hexakisphosphate. Elife, 4:-, 2015 Cited by PubMed: 25699547 DOI: 10.7554/eLife.06074 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.599 Å)

Structure validation