1Z95
| Crystal Structure of the Androgen Receptor Ligand-binding Domain W741L Mutant Complex with R-bicalutamide | 分子名称: | Androgen Receptor, R-BICALUTAMIDE, SULFATE ION | 著者 | Bohl, C.E, Gao, W, Miller, D.D, Bell, C.E, Dalton, J.T. | 登録日 | 2005-03-31 | 公開日 | 2005-04-19 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Structural basis for antagonism and resistance of bicalutamide in prostate cancer. Proc.Natl.Acad.Sci.Usa, 102, 2005
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6IEJ
| The C2 domain of cytosolic phospholipase A2 alpha bound to phosphatidylcholine | 分子名称: | 1,2-dihexanoyl-sn-glycero-3-phosphocholine, CALCIUM ION, Cytosolic phospholipase A2, ... | 著者 | Hirano, Y, Gao, Y.G, Stephenson, D.J, Vu, N.T, Malinina, L, Chalfant, C.E, Patel, D.J, Brown, R.E. | 登録日 | 2018-09-14 | 公開日 | 2019-05-22 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.206 Å) | 主引用文献 | Structural basis of phosphatidylcholine recognition by the C2-domain of cytosolic phospholipase A2alpha. Elife, 8, 2019
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6GQX
| KRAS-169 Q61H GPPNHP + CH-2 | 分子名称: | GTPase KRas, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... | 著者 | Cruz-Migoni, A, Quevedo, C.E, Carr, S.B, Phillips, S.E.V, Rabbitts, T.H. | 登録日 | 2018-06-08 | 公開日 | 2019-02-06 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Structure-based development of new RAS-effector inhibitors from a combination of active and inactive RAS-binding compounds. Proc. Natl. Acad. Sci. U.S.A., 116, 2019
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6GOM
| KRAS-169 Q61H GPPNHP + PPIN-1 | 分子名称: | (6~{S})-1-(1~{H}-imidazol-4-ylcarbonyl)-6-[(4-phenylphenyl)methyl]-4-propyl-1,4-diazepan-5-one, CITRIC ACID, GTPase KRas, ... | 著者 | Cruz-Migoni, A, Canning, P, Quevedo, C.E, Carr, S.B, Phillips, S.E.V, Rabbitts, T.H. | 登録日 | 2018-06-01 | 公開日 | 2019-02-06 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.63 Å) | 主引用文献 | Structure-based development of new RAS-effector inhibitors from a combination of active and inactive RAS-binding compounds. Proc. Natl. Acad. Sci. U.S.A., 116, 2019
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9FQ9
| Crystal structure of SARS-CoV-2 main protease (MPro) in complex with the covalently bound inhibitor PSB-21110 (compound 29b in publication) | 分子名称: | (5-chloranylpyridin-3-yl) 4-ethoxy-2-fluoranyl-benzoate, BROMIDE ION, Non-structural protein 11 | 著者 | Strater, N, Claff, T, Sylvester, K, Oneto, A, Guetschow, M, Mueller, C.E. | 登録日 | 2024-06-19 | 公開日 | 2024-08-28 | 最終更新日 | 2024-09-25 | 実験手法 | X-RAY DIFFRACTION (1.25 Å) | 主引用文献 | Nonpeptidic Irreversible Inhibitors of SARS-CoV-2 Main Protease with Potent Antiviral Activity. J.Med.Chem., 67, 2024
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9FQA
| Crystal structure of SARS-CoV-2 main protease (MPro) in complex with the covalently bound inhibitor PSB-21101 (compound 30b in publication) | 分子名称: | (5-chloranylpyridin-3-yl) 2-fluoranyl-4-phenylmethoxy-benzoate, BROMIDE ION, MAGNESIUM ION, ... | 著者 | Strater, N, Claff, T, Sylvester, K, Oneto, A, Guetschow, M, Mueller, C.E. | 登録日 | 2024-06-14 | 公開日 | 2024-08-28 | 最終更新日 | 2024-09-25 | 実験手法 | X-RAY DIFFRACTION (1.47 Å) | 主引用文献 | Nonpeptidic Irreversible Inhibitors of SARS-CoV-2 Main Protease with Potent Antiviral Activity. J.Med.Chem., 67, 2024
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8TLC
| Human mitochondrial serine hydroxymethyltransferase (SHMT2) in complex with PLP, glycine and tri-glutamate AGF347 inhibitor | 分子名称: | N-{4-[4-(2-amino-4-oxo-1,4-dihydro-5H-pyrrolo[3,2-d]pyrimidin-5-yl)butyl]-2-fluorobenzoyl}-D-gamma-glutamyl-L-gamma-glutamyl-D-glutamic acid, Serine hydroxymethyltransferase, mitochondrial | 著者 | Katinas, J.M, Dann III, C.E. | 登録日 | 2023-07-26 | 公開日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.72 Å) | 主引用文献 | Structural Characterization of 5-Substituted Pyrrolo[3,2- d ]pyrimidine Antifolate Inhibitors in Complex with Human Serine Hydroxymethyl Transferase 2. Biochemistry, 2024
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2AX8
| Crystal Structure Of The Androgen Receptor Ligand Binding Domain W741L Mutant In Complex With S-1 | 分子名称: | Androgen receptor, S-3-(4-FLUOROPHENOXY)-2-HYDROXY-2-METHYL-N-[4-NITRO-3-(TRIFLUOROMETHYL)PHENYL]PROPANAMIDE | 著者 | Bohl, C.E, Miller, D.D, Chen, J, Bell, C.E, Dalton, J.T. | 登録日 | 2005-09-03 | 公開日 | 2005-09-20 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Structural Basis for Accommodation of Nonsteroidal Ligands in the Androgen Receptor J.Biol.Chem., 280, 2005
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2AX9
| Crystal Structure Of The Androgen Receptor Ligand Binding Domain In Complex With R-3 | 分子名称: | (R)-3-BROMO-2-HYDROXY-2-METHYL-N-[4-NITRO-3-(TRIFLUOROMETHYL)PHENYL]PROPANAMIDE, Androgen receptor | 著者 | Bohl, C.E, Miller, D.D, Chen, J, Bell, C.E, Dalton, J.T. | 登録日 | 2005-09-03 | 公開日 | 2005-09-20 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | Structural Basis for Accommodation of Nonsteroidal Ligands in the Androgen Receptor J.Biol.Chem., 280, 2005
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2AX6
| Crystal Structure Of The Androgen Receptor Ligand Binding Domain T877A Mutant In Complex With Hydroxyflutamide | 分子名称: | Androgen receptor, HYDROXYFLUTAMIDE | 著者 | Bohl, C.E, Miller, D.D, Chen, J, Bell, C.E, Dalton, J.T. | 登録日 | 2005-09-03 | 公開日 | 2005-09-20 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Structural Basis for Accommodation of Nonsteroidal Ligands in the Androgen Receptor J.Biol.Chem., 280, 2005
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2AXA
| Crystal Structure Of The Androgen Receptor Ligand Binding Domain In Complex With S-1 | 分子名称: | Androgen receptor, S-3-(4-FLUOROPHENOXY)-2-HYDROXY-2-METHYL-N-[4-NITRO-3-(TRIFLUOROMETHYL)PHENYL]PROPANAMIDE | 著者 | Bohl, C.E, Miller, D.D, Chen, J, Bell, C.E, Dalton, J.T. | 登録日 | 2005-09-03 | 公開日 | 2005-09-20 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Structural Basis for Accommodation of Nonsteroidal Ligands in the Androgen Receptor J.Biol.Chem., 280, 2005
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2AX7
| Crystal Structure Of The Androgen Receptor Ligand Binding Domain T877A Mutant In Complex With S-1 | 分子名称: | Androgen receptor, S-3-(4-FLUOROPHENOXY)-2-HYDROXY-2-METHYL-N-[4-NITRO-3-(TRIFLUOROMETHYL)PHENYL]PROPANAMIDE | 著者 | Bohl, C.E, Miller, D.D, Chen, J, Bell, C.E, Dalton, J.T. | 登録日 | 2005-09-03 | 公開日 | 2005-09-20 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Structural Basis for Accommodation of Nonsteroidal Ligands in the Androgen Receptor J.Biol.Chem., 280, 2005
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1HK4
| HUMAN SERUM ALBUMIN COMPLEXED WITH THYROXINE (3,3',5,5'-TETRAIODO-L-THYRONINE) and myristic acid (tetradecanoic acid) | 分子名称: | 3,5,3',5'-TETRAIODO-L-THYRONINE, MYRISTIC ACID, SERUM ALBUMIN | 著者 | Petitpas, I, Petersen, C.E, Ha, C.E, Bhattacharya, A.A, Zunszain, P.A, Ghuman, J, Bhagavan, N.V, Curry, S. | 登録日 | 2003-03-05 | 公開日 | 2003-05-16 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Structural Basis of Albumin-Thyroxine Interactions and Familial Dysalbuminemic Hyperthyroxinemia Proc.Natl.Acad.Sci.USA, 100, 2003
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1HK5
| HUMAN SERUM ALBUMIN MUTANT R218H COMPLEXED WITH THYROXINE (3,3',5,5'-TETRAIODO-L-THYRONINE) and myristic acid (tetradecanoic acid) | 分子名称: | 3,5,3',5'-TETRAIODO-L-THYRONINE, MYRISTIC ACID, SERUM ALBUMIN | 著者 | Petitpas, I, Petersen, C.E, Ha, C.E, Bhattacharya, A.A, Zunszain, P.A, Ghuman, J, Bhagavan, N.V, Curry, S. | 登録日 | 2003-03-05 | 公開日 | 2003-05-16 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Structural Basis of Albumin-Thyroxine Interactions and Familial Dysalbuminemic Hyperthyroxinemia Proc.Natl.Acad.Sci.USA, 100, 2003
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1HK1
| HUMAN SERUM ALBUMIN COMPLEXED WITH THYROXINE (3,3',5,5'-TETRAIODO-L-THYRONINE) | 分子名称: | 3,5,3',5'-TETRAIODO-L-THYRONINE, SERUM ALBUMIN | 著者 | Petitpas, I, Petersen, C.E, Ha, C.E, Bhattacharya, A.A, Zunszain, P.A, Ghuman, J, Bhagavan, N.V, Curry, S. | 登録日 | 2003-03-05 | 公開日 | 2003-05-16 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | 主引用文献 | Structural Basis of Albumin-Thyroxine Interactions and Familial Dysalbuminemic Hyperthyroxinemia Proc.Natl.Acad.Sci.USA, 100, 2003
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1HK3
| Human serum albumin mutant r218p complexed with thyroxine (3,3',5,5'-tetraiodo-l-thyronine) | 分子名称: | 3,5,3',5'-TETRAIODO-L-THYRONINE, SERUM ALBUMIN | 著者 | Petitpas, I, Petersen, C.E, Ha, C.E, Bhattacharya, A.A, Zunszain, P.A, Ghuman, J, Bhagavan, N.V, Curry, S. | 登録日 | 2003-03-05 | 公開日 | 2003-05-16 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Structural Basis of Albumin-Thyroxine Interactions and Familial Dysalbuminemic Hyperthyroxinemia Proc.Natl.Acad.Sci.USA, 100, 2003
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1HK2
| HUMAN SERUM ALBUMIN MUTANT R218H COMPLEXED WITH THYROXINE (3,3',5,5'-TETRAIODO-L-THYRONINE) | 分子名称: | 3,5,3',5'-TETRAIODO-L-THYRONINE, SERUM ALBUMIN | 著者 | Petitpas, I, Petersen, C.E, Ha, C.E, Bhattacharya, A.A, Zunszain, P.A, Ghuman, J, Bhagavan, N.V, Curry, S. | 登録日 | 2003-03-05 | 公開日 | 2003-05-16 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Structural Basis of Albumin-Thyroxine Interactions and Familial Dysalbuminemic Hyperthyroxinemia Proc.Natl.Acad.Sci.USA, 100, 2003
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3CLN
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1ML2
| Crystal Structure of a Mutant Variant of Cytochrome c Peroxidase with Zn(II)-(20-oxo-Protoporphyrin IX) | 分子名称: | 20-OXO-PROTOPORPHYRIN IX CONTAINING ZN(II), Cytochrome c Peroxidase | 著者 | Bhaskar, B, Immoos, C.E, Shimizu, H, Farmer, P.J, Poulos, T.L. | 登録日 | 2002-08-29 | 公開日 | 2003-04-08 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | A Novel Heme and Peroxide-Dependent Tryptophan-Tyrosine Cross-Link in a Mutant of Cytochrome c Peroxidase J.Mol.Biol., 328, 2003
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1MK8
| Crystal Structure of a Mutant Cytochrome c Peroxidase showing a Novel Trp-Tyr Covalent Cross-link | 分子名称: | Cytochrome c Peroxidase, PROTOPORPHYRIN IX CONTAINING FE | 著者 | Bhaskar, B, Immoos, C.E, Shimizu, H, Farmer, P.J, Poulos, T.L. | 登録日 | 2002-08-28 | 公開日 | 2003-04-08 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | A Novel Heme and Peroxide-Dependent Tryptophan-Tyrosine Cross-Link in a Mutant of Cytochrome c Peroxidase J.Mol.Biol., 328, 2003
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1MKQ
| Crystal Structure of the Mutant Variant of Cytochrome c Peroxidase in the 'Open' Uncross-linked form | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, Cytochrome c Peroxidase, PROTOPORPHYRIN IX CONTAINING FE | 著者 | Bhaskar, B, Immoos, C.E, Shimizu, H, Farmer, P.J, Poulos, T.L. | 登録日 | 2002-08-29 | 公開日 | 2003-04-08 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (1.64 Å) | 主引用文献 | A Novel Heme and Peroxide-Dependent Tryptophan-Tyrosine Cross-Link in a Mutant of Cytochrome c Peroxidase J.Mol.Biol., 328, 2003
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2OZ7
| Crystal structure of the human androgen receptor T877A mutant ligand-binding domain with cyproterone acetate | 分子名称: | Androgen receptor, CYPROTERONE ACETATE | 著者 | Bohl, C.E, Wu, Z, Miller, D.D, Bell, C.E, Dalton, J.T. | 登録日 | 2007-02-25 | 公開日 | 2007-03-27 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Crystal structure of the T877A human androgen receptor ligand-binding domain complexed to cyproterone acetate provides insight for ligand-induced conformational changes and structure-based drug design. J.Biol.Chem., 282, 2007
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5E6Q
| Importin alpha binding to XRCC1 NLS peptide | 分子名称: | CHLORIDE ION, DNA repair protein XRCC1 NLS peptide, GLYCEROL, ... | 著者 | Pedersen, L.C, Kirby, T.W, Gassman, N.R, Smith, C.E, Gabel, S.A, Sobhany, M, Wilson, S.H, London, R.E. | 登録日 | 2015-10-10 | 公開日 | 2015-10-28 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.305 Å) | 主引用文献 | Nuclear Localization of the DNA Repair Scaffold XRCC1: Uncovering the Functional Role of a Bipartite NLS. Sci Rep, 5, 2015
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5ELP
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5EKA
| HU DNA-binding protein from Thermus thermophilus | 分子名称: | DNA-binding protein HU, GLYCEROL | 著者 | Papageorgiou, A, Adam, P, Stavros, P, Nounesis, G, Meijers, R, Petratos, K, Vorgias, C.E. | 登録日 | 2015-11-03 | 公開日 | 2016-07-06 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.69 Å) | 主引用文献 | HU histone-like DNA-binding protein from Thermus thermophilus: structural and evolutionary analyses. Extremophiles, 20, 2016
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