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PDB: 2662 件

7UV9
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KDM2A-nucleosome structure stabilized by H3K36C-UNC8015 covalent conjugate
分子名称: DNA (185-MER), FE (III) ION, Histone H2A type 1, ...
著者Spangler, C.J, Skrajna, A, Foley, C.A, Budziszewski, G.R, Azzam, D.N, James, L.I, Frye, S.V, McGinty, R.K.
登録日2022-04-29
公開日2023-02-22
最終更新日2024-06-12
実験手法ELECTRON MICROSCOPY (3.2 Å)
主引用文献Structural basis of paralog-specific KDM2A/B nucleosome recognition.
Nat.Chem.Biol., 19, 2023
7UVA
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Crystal structure of KDM2A histone demethylase catalytic domain in complex with an H3C36 peptide modified by UNC8015
分子名称: FE (III) ION, Histone H3.2, Lysine-specific demethylase 2A, ...
著者Budziszewski, G.R, Azzam, D.N, Spangler, C.J, Skrajna, A, Foley, C.A, James, L.I, Frye, S.V, McGinty, R.K.
登録日2022-04-29
公開日2023-02-22
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (1.98 Å)
主引用文献Structural basis of paralog-specific KDM2A/B nucleosome recognition.
Nat.Chem.Biol., 19, 2023
1MS6
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Dipeptide Nitrile Inhibitor Bound to Cathepsin S.
分子名称: Cathepsin S, MORPHOLINE-4-CARBOXYLIC ACID [1S-(2-BENZYLOXY-1R-CYANO-ETHYLCARBAMOYL)-3-METHYL-BUTYL]AMIDE
著者Ward, Y.D, Thomson, D.S, Frye, L.L, Cywin, C.L, Morwick, T, Emmanuel, M.J, Zindell, R, McNeil, D, Bekkali, Y, Giradot, M, Hrapchak, M, DeTuri, M, Crane, K, White, D, Pav, S, Wang, Y, Hao, M.H, Grygon, C.A, Labadia, M.E, Freeman, D.M, Davidson, W, Hopkins, J.L, Brown, M.L, Spero, D.M.
登録日2002-09-19
公開日2003-04-22
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Design and synthesis of dipeptide nitriles as reversible and potent Cathepsin S inhibitors
J.Med.Chem., 45, 2002
4OPF
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Streptomcyes albus JA3453 oxazolomycin ketosynthase domain OzmH KS8
分子名称: NRPS/PKS
著者Osipiuk, J, Bigelow, L, Endres, M, Babnigg, G, Bingman, C.A, Yennamalli, R, Lohman, J.R, Ma, M, Shen, B, Phillips Jr, G.N, Joachimiak, A, Midwest Center for Structural Genomics (MCSG), Enzyme Discovery for Natural Product Biosynthesis (NatPro)
登録日2014-02-05
公開日2014-02-19
最終更新日2017-11-22
実験手法X-RAY DIFFRACTION (2.12 Å)
主引用文献Structural and evolutionary relationships of "AT-less" type I polyketide synthase ketosynthases.
Proc.Natl.Acad.Sci.USA, 112, 2015
1MY6
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The 1.6 A Structure of Fe-Superoxide Dismutase from the thermophilic cyanobacterium Thermosynechococcus elongatus : Correlation of EPR and Structural Characteristics
分子名称: FE (III) ION, Iron (III) Superoxide Dismutase
著者Yoshida, S.M, Cascio, D, Sawaya, M.R, Yeates, T.O, Kerfeld, C.A.
登録日2002-10-03
公開日2003-07-29
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献The 1.6 A resolution structure of Fe-superoxide dismutase from the thermophilic cyanobacterium Thermosynechococcus elongatus.
J.BIOL.INORG.CHEM., 8, 2003
3DCY
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BU of 3dcy by Molmil
Crystal Structure a TP53-induced glycolysis and apoptosis regulator protein from Homo sapiens.
分子名称: PHOSPHATE ION, REGULATOR PROTEIN
著者McCoy, J.G, Bingman, C.A, Wesenberg, G.E, Phillips Jr, G.N, Center for Eukaryotic Structural Genomics (CESG)
登録日2008-06-04
公開日2008-07-15
最終更新日2017-10-25
実験手法X-RAY DIFFRACTION (1.748 Å)
主引用文献Crystal Structure a TP53-induced glycolysis and apoptosis regulator protein from Homo sapiens.
To be Published
3DI2
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Crystal structure of the complex of human interleukin-7 with unglycosylated human interleukin-7 receptor alpha ectodomain
分子名称: Interleukin-7, Interleukin-7 receptor subunit alpha, PENTAETHYLENE GLYCOL
著者McElroy, C.A, Dohm, J.A, Walsh, S.T.R.
登録日2008-06-19
公開日2009-01-27
最終更新日2021-10-20
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Structural and Biophysical Studies of the Human IL-7/IL-7Ralpha Complex.
Structure, 17, 2009
4OO2
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Streptomyces globisporus C-1027 FAD dependent (S)-3-chloro-β-tyrosine-S-SgcC2 C-5 hydroxylase SgcC apo form
分子名称: CALCIUM ION, Chlorophenol-4-monooxygenase, GLYCEROL
著者Cao, H, Xu, W, Bingman, C.A, Lohman, J.R, Yennamalli, R, Shen, B, Phillips Jr, G.N, Enzyme Discovery for Natural Product Biosynthesis (NatPro)
登録日2014-01-29
公開日2014-02-12
最終更新日2023-03-22
実験手法X-RAY DIFFRACTION (2.63 Å)
主引用文献Crystal Structures of SgcE6 and SgcC, the Two-Component Monooxygenase That Catalyzes Hydroxylation of a Carrier Protein-Tethered Substrate during the Biosynthesis of the Enediyne Antitumor Antibiotic C-1027 in Streptomyces globisporus.
Biochemistry, 55, 2016
4OX7
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Structure of Synechococcus elongatus PCC 7942 CcmK2
分子名称: Carbon dioxide-concentrating mechanism protein CcmK
著者Sutter, M, Kinney, J.N, Cai, F, Kerfeld, C.A.
登録日2014-02-04
公開日2014-08-27
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.1001 Å)
主引用文献Engineering Bacterial Microcompartment Shells: Chimeric Shell Proteins and Chimeric Carboxysome Shells.
Acs Synth Biol, 2014
1NP4
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BU of 1np4 by Molmil
CRYSTAL STRUCTURE OF NITROPHORIN 4 FROM RHODNIUS PROLIXUS
分子名称: AMMONIA, PROTEIN (NITROPHORIN 4), PROTOPORPHYRIN IX CONTAINING FE
著者Andersen, J.F, Weichsel, A, Champagne, D.E, Balfour, C.A, Montfort, W.R.
登録日1998-07-29
公開日1998-08-05
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献The crystal structure of nitrophorin 4 at 1.5 A resolution: transport of nitric oxide by a lipocalin-based heme protein.
Structure, 6, 1998
3E82
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BU of 3e82 by Molmil
Crystal structure of a putative oxidoreductase from Klebsiella pneumoniae
分子名称: CHLORIDE ION, Putative oxidoreductase
著者Eswaramoorthy, S, Mohammad, M.B, Thomas, C.A, Brown, A.C, Burley, S.K, Swaminathan, S, New York SGX Research Center for Structural Genomics (NYSGXRC)
登録日2008-08-19
公開日2008-08-26
最終更新日2021-02-10
実験手法X-RAY DIFFRACTION (2.04 Å)
主引用文献Crystal structure of a putative oxidoreductase from Klebsiella pneumoniae
To be Published
4OCW
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BU of 4ocw by Molmil
Crystal structure of human Fab CAP256-VRC26.06, a potent V1V2-directed HIV-1 neutralizing antibody
分子名称: CAP256-VRC26.06 heavy chain, CAP256-VRC26.06 light chain
著者Gorman, J, Doria-Rose, N.A, Schramm, C.A, Moore, P.L, Mascola, J.R, Shapiro, L, Morris, L, Kwong, P.D.
登録日2014-01-09
公開日2014-02-26
最終更新日2023-12-06
実験手法X-RAY DIFFRACTION (3.001 Å)
主引用文献Developmental pathway for potent V1V2-directed HIV-neutralizing antibodies.
Nature, 509, 2014
1NND
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BU of 1nnd by Molmil
Arginine 116 is Essential for Nucleic Acid Recognition by the Fingers Domain of Moloney Murine Leukemia Virus Reverse Transcriptase
分子名称: Reverse Transcriptase
著者Crowther, R.L, Remeta, D.P, Minetti, C.A, Das, D, Montano, S.P, Georgiadis, M.M.
登録日2003-01-13
公開日2004-01-27
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Structural and energetic characterization of nucleic acid-binding to the fingers domain of Moloney murine leukemia virus reverse transcriptase
Proteins, 57, 2004
6X5Y
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BU of 6x5y by Molmil
IDO1 in complex with compound 4
分子名称: 4-fluoro-N-{1-[5-(2-methylpyrimidin-4-yl)-5,6,7,8-tetrahydro-1,5-naphthyridin-2-yl]cyclopropyl}benzamide, Indoleamine 2,3-dioxygenase 1
著者Lesburg, C.A, Lammens, A.
登録日2020-05-27
公開日2021-06-02
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.65 Å)
主引用文献Utilization of MetID and Structural Data to Guide Placement of Spiro and Fused Cyclopropyl Groups for the Synthesis of Low Dose IDO1 Inhibitors
To Be Published
1NR7
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BU of 1nr7 by Molmil
Crystal structure of apo bovine glutamate dehydrogenase
分子名称: Glutamate dehydrogenase 1
著者Banerjee, S, Schmidt, T, Fang, J, Stanley, C.A, Smith, T.J.
登録日2003-01-23
公開日2003-05-06
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (3.3 Å)
主引用文献Structural studies on ADP activation of mammalian glutamate dehydrogenase and the evolution of regulation
Biochemistry, 42, 2003
3EA6
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BU of 3ea6 by Molmil
Atomic resolution of crystal structure of SEK
分子名称: IODIDE ION, Staphylococcal enterotoxin K, ZINC ION
著者Shi, K, Huseby, M, Schlievert, P.M, Ohlendorf, D.H, Earhart, C.A.
登録日2008-08-24
公開日2009-06-30
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (0.92 Å)
主引用文献Structural Studies of an Emerging Pyrogenic Superantigen, SEK
To be Published
4O89
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BU of 4o89 by Molmil
Crystal structure of RtcA, the RNA 3'-terminal phosphate cyclase from Pyrococcus horikoshii.
分子名称: CITRIC ACID, RNA 3'-terminal phosphate cyclase
著者Desai, K.K, Bingman, C.A, Phillips Jr, G.N, Raines, R.T.
登録日2013-12-26
公開日2014-09-10
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structure of RNA 3'-phosphate cyclase bound to substrate RNA.
Rna, 20, 2014
3EKX
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BU of 3ekx by Molmil
Crystal structure of the wild-type HIV-1 protease with the inhibitor, Nelfinavir
分子名称: 2-[2-HYDROXY-3-(3-HYDROXY-2-METHYL-BENZOYLAMINO)-4-PHENYL SULFANYL-BUTYL]-DECAHYDRO-ISOQUINOLINE-3-CARBOXYLIC ACID TERT-BUTYLAMIDE, ACETATE ION, Protease
著者Schiffer, C.A, Nalam, M.N.L.
登録日2008-09-19
公開日2009-09-01
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.97 Å)
主引用文献Extreme Entropy-Enthalpy Compensation in a Drug-Resistant Variant of HIV-1 Protease.
Acs Chem.Biol., 7, 2012
6XAT
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BU of 6xat by Molmil
Crystal structure of the human FoxP4 DNA binding Domain
分子名称: FOXP4 protein, SODIUM ION
著者VIllalobos, P, Castro-Fernandez, V, Medina, E, Gonzalez-Ordenes, F, Maturana, P, Herrera-Morande, A, Ramirez-Sarmiento, C.A, Babul, J.
登録日2020-06-04
公開日2021-06-09
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Unraveling the folding and dimerization properties of the human FoxP subfamily of transcription factors.
Febs Lett., 597, 2023
4ODH
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Crystal structure of human Fab CAP256-VRC26.UCA, a potent V1V2-directed HIV-1 neutralizing antibody
分子名称: CAP256-VRC26.UCA heavy chain, CAP256-VRC26.UCA light chain
著者Gorman, J, Doria-Rose, N.A, Schramm, C.A, Moore, P.L, Mascola, J.R, Shapiro, L, Morris, L, Kwong, P.D.
登録日2014-01-10
公開日2014-02-26
最終更新日2023-12-06
実験手法X-RAY DIFFRACTION (2.894 Å)
主引用文献Developmental pathway for potent V1V2-directed HIV-neutralizing antibodies.
Nature, 509, 2014
3EKQ
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Crystal structure of inhibitor saquinavir (SQV) in complex with multi-drug resistant HIV-1 protease (L63P/V82T/I84V) (referred to as ACT in paper)
分子名称: (2S)-N-[(2S,3R)-4-[(2S,3S,4aS,8aS)-3-(tert-butylcarbamoyl)-3,4,4a,5,6,7,8,8a-octahydro-1H-isoquinolin-2-yl]-3-hydroxy-1 -phenyl-butan-2-yl]-2-(quinolin-2-ylcarbonylamino)butanediamide, PHOSPHATE ION, Protease
著者Prabu-Jeyabalan, M, King, N.M, Schiffer, C.A, Nalivaika, E.
登録日2008-09-19
公開日2009-09-01
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Extreme Entropy-Enthalpy Compensation in a Drug-Resistant Variant of HIV-1 Protease.
Acs Chem.Biol., 7, 2012
3EM6
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BU of 3em6 by Molmil
Crystal structure of I50L/A71V mutant of hiv-1 protease in complex with inhibitor darunavir
分子名称: (3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE, ACETATE ION, PHOSPHATE ION, ...
著者Royer, C.J, King, N.M, Prabu-Jeyabalan, M, Ng, C, Nalivaika, E.A, Schiffer, C.A.
登録日2008-09-23
公開日2009-09-01
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Kinetic and structural studies on atazanavir specific I50L drug-resistant HIV-1 protease mutant.
To be Published
4DJO
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Crystal Structure of wild-type HIV-1 Protease in Complex with MKP56
分子名称: 2-[(dichloroacetyl)amino]ethyl [(2S,3R)-3-hydroxy-4-{[(4-methoxyphenyl)sulfonyl][(2S)-2-methylbutyl]amino}-1-phenylbutan-2-yl]carbamate, ACETATE ION, GLYCEROL, ...
著者Schiffer, C.A, Nalam, M.N.L.
登録日2012-02-02
公開日2012-08-01
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.78 Å)
主引用文献Design, synthesis, and biological and structural evaluations of novel HIV-1 protease inhibitors to combat drug resistance.
J.Med.Chem., 55, 2012
4DJQ
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Crystal Structure of wild-type HIV-1 Protease in Complex with MKP86
分子名称: 2-(2-oxoimidazolidin-1-yl)ethyl [(2S,3R)-3-hydroxy-4-{[(4-methoxyphenyl)sulfonyl][(2S)-2-methylbutyl]amino}-1-phenylbutan-2-yl]carbamate, PHOSPHATE ION, Pol polyprotein
著者Schiffer, C.A, Nalam, M.N.L.
登録日2012-02-02
公開日2012-08-01
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Design, synthesis, and biological and structural evaluations of novel HIV-1 protease inhibitors to combat drug resistance.
J.Med.Chem., 55, 2012
1OR7
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BU of 1or7 by Molmil
Crystal Structure of Escherichia coli sigmaE with the Cytoplasmic Domain of its Anti-sigma RseA
分子名称: RNA polymerase sigma-E factor, Sigma-E factor negative regulatory protein
著者Campbell, E.A, Tupy, J.L, Gruber, T.M, Wang, S, Sharp, M.M, Gross, C.A, Darst, S.A.
登録日2003-03-12
公開日2003-04-15
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Crystal structure of Escherichia coli sigmaE with the cytoplasmic domain of its anti-sigma RseA.
Mol.Cell, 11, 2003

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