3QSU
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4CRO
| PROTEIN-DNA CONFORMATIONAL CHANGES IN THE CRYSTAL STRUCTURE OF A LAMBDA CRO-OPERATOR COMPLEX | Descriptor: | DNA (5'-D(*TP*AP*TP*CP*AP*CP*CP*GP*CP*GP*GP*GP*TP*GP*AP*TP*A)-3'), PROTEIN (LAMBDA CRO) | Authors: | Brennan, R.G, Roderick, S.L, Takeda, Y, Matthews, B.W. | Deposit date: | 1992-01-15 | Release date: | 1992-01-15 | Last modified: | 2022-11-23 | Method: | X-RAY DIFFRACTION (3.9 Å) | Cite: | Protein-DNA conformational changes in the crystal structure of a lambda Cro-operator complex. Proc.Natl.Acad.Sci.USA, 87, 1990
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1DN8
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2PFB
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2PEX
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3ECO
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8SSH
| MtrR from Neisseria gonorrhoeae bound to Ethinyl Estradiol | Descriptor: | Ethinyl estradiol, HTH-type transcriptional regulator MtrR, PHOSPHATE ION | Authors: | Hooks, G.M, Brennan, R.G. | Deposit date: | 2023-05-08 | Release date: | 2024-02-14 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Hormonal steroids induce multidrug resistance and stress response genes in Neisseria gonorrhoeae by binding to MtrR. Nat Commun, 15, 2024
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1BDH
| PURINE REPRESSOR MUTANT-HYPOXANTHINE-PALINDROMIC OPERATOR COMPLEX | Descriptor: | DNA (5'-D(*TP*AP*CP*GP*CP*AP*AP*AP*CP*GP*TP*TP*TP*GP*CP*GP*T )-3'), HYPOXANTHINE, PROTEIN (PURINE REPRESSOR) | Authors: | Glasfeld, A, Schumacher, M.A, Choi, K.Y, Zalkin, H, Brennan, R.G. | Deposit date: | 1996-07-25 | Release date: | 1997-04-21 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | A Positively Charged Residue Bound in the Minor Groove Does not Alter the Bending of a DNA Duplex J.Am.Chem.Soc., 118, 1996
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1BDI
| PURINE REPRESSOR MUTANT-HYPOXANTHINE-PALINDROMIC OPERATOR COMPLEX | Descriptor: | DNA (5'-D(*TP*AP*CP*GP*CP*AP*AP*AP*CP*GP*TP*TP*TP*GP*CP*GP*T )-3'), HYPOXANTHINE, PROTEIN (PURINE REPRESSOR) | Authors: | Glasfeld, A, Schumacher, M.A, Choi, K.Y, Zalkin, H, Brennan, R.G. | Deposit date: | 1996-07-25 | Release date: | 1997-04-21 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | A Positively Charged Residue Bound in the Minor Groove Does not Alter the Bending of a DNA Duplex J.Am.Chem.Soc., 118, 1996
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8FW0
| MtrR from Neisseria gonorrhoeae bound to beta-Estradiol | Descriptor: | ESTRADIOL, GLYCEROL, HTH-type transcriptional regulator MtrR, ... | Authors: | Hooks, G.H, Brennan, R.G. | Deposit date: | 2023-01-20 | Release date: | 2024-01-24 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.37 Å) | Cite: | Hormonal steroids induce multidrug resistance and stress response genes in Neisseria gonorrhoeae by binding to MtrR. Nat Commun, 15, 2024
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8FW8
| MtrR from Neisseria gonorrhoeae bound to Progesterone | Descriptor: | 3-CYCLOHEXYL-1-PROPYLSULFONIC ACID, HTH-type transcriptional regulator MtrR, PHOSPHATE ION, ... | Authors: | Hooks, G.H, Brennan, R.G. | Deposit date: | 2023-01-20 | Release date: | 2024-01-24 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.31 Å) | Cite: | Hormonal steroids induce multidrug resistance and stress response genes in Neisseria gonorrhoeae by binding to MtrR. Nat Commun, 15, 2024
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1BD4
| UPRT-URACIL COMPLEX | Descriptor: | PHOSPHATE ION, URACIL, URACIL PHOSPHORIBOSYLTRANSFERASE | Authors: | Schumacher, M.A, Carter, D, Scott, D, Roos, D, Ullman, B, Brennan, R.G. | Deposit date: | 1998-05-12 | Release date: | 1999-05-18 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Crystal structures of Toxoplasma gondii uracil phosphoribosyltransferase reveal the atomic basis of pyrimidine discrimination and prodrug binding. EMBO J., 17, 1998
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8FW3
| MtrR from Neisseria gonorrhoeae bound to Testosterone | Descriptor: | HTH-type transcriptional regulator MtrR, PHOSPHATE ION, TESTOSTERONE | Authors: | Hooks, G.H, Brennan, R.G. | Deposit date: | 2023-01-20 | Release date: | 2024-01-24 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.22 Å) | Cite: | Hormonal steroids induce multidrug resistance and stress response genes in Neisseria gonorrhoeae by binding to MtrR. Nat Commun, 15, 2024
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1BD3
| STRUCTURE OF THE APO URACIL PHOSPHORIBOSYLTRANSFERASE, 2 MUTANT C128V | Descriptor: | PHOSPHATE ION, URACIL PHOSPHORIBOSYLTRANSFERASE | Authors: | Schumacher, M.A, Carter, D, Scott, D, Roos, D, Ullman, B, Brennan, R.G. | Deposit date: | 1998-05-12 | Release date: | 1999-05-18 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.93 Å) | Cite: | Crystal structures of Toxoplasma gondii uracil phosphoribosyltransferase reveal the atomic basis of pyrimidine discrimination and prodrug binding. EMBO J., 17, 1998
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1BOW
| MULTIDRUG-BINDING DOMAIN OF TRANSCRIPTION ACTIVATOR BMRR (APO FORM) | Descriptor: | MANGANESE (II) ION, MULTIDRUG-EFFLUX TRANSPORTER 1 REGULATOR BMRR | Authors: | Zheleznova, E.E, Markham, P.N, Neyfakh, A.A, Brennan, R.G. | Deposit date: | 1998-08-06 | Release date: | 1999-08-06 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Structural basis of multidrug recognition by BmrR, a transcription activator of a multidrug transporter. Cell(Cambridge,Mass.), 96, 1999
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8FHW
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8FO1
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6WEG
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6WMP
| F. tularensis RNAPs70-iglA DNA complex | Descriptor: | DNA NT-strand, DNA T-strand, DNA-directed RNA polymerase subunit alpha 1, ... | Authors: | Travis, B.A, Brennan, R.G, Schumacher, M.A. | Deposit date: | 2020-04-21 | Release date: | 2020-11-11 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (2.98 Å) | Cite: | Structural Basis for Virulence Activation of Francisella tularensis. Mol.Cell, 81, 2021
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6OF0
| Structural basis for multidrug recognition and antimicrobial resistance by MTRR, an efflux pump regulator from Neisseria Gonorrhoeae | Descriptor: | HTH-type transcriptional regulator MtrR, PHOSPHATE ION | Authors: | Beggs, G.A, Kumaraswami, M, Shafer, W, Brennan, R.G. | Deposit date: | 2019-03-28 | Release date: | 2019-07-31 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural, Biochemical, and In Vivo Characterization of MtrR-Mediated Resistance to Innate Antimicrobials by the Human Pathogen Neisseria gonorrhoeae . J.Bacteriol., 201, 2019
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1HAB
| CROSSLINKED HAEMOGLOBIN | Descriptor: | 4-CARBOXYCINNAMIC ACID, CARBON MONOXIDE, HEMOGLOBIN A, ... | Authors: | Schumacher, M.A, Dixon, M.M, Kluger, R, Jones, R.T, Brennan, R.G. | Deposit date: | 1996-03-13 | Release date: | 1997-11-12 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Allosteric intermediates indicate R2 is the liganded hemoglobin end state. Proc.Natl.Acad.Sci.USA, 94, 1997
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2PUE
| CRYSTAL STRUCTURE OF THE LACI FAMILY MEMBER, PURR, BOUND TO DNA: MINOR GROOVE BINDING BY ALPHA HELICES | Descriptor: | ADENINE, DNA (5'-D(*TP*AP*CP*GP*CP*AP*AP*AP*CP*GP*TP*TP*TP*GP*CP*GP*T )-3'), PROTEIN (PURINE REPRESSOR ) | Authors: | Lu, F, Schumacher, M.A, Arvidson, D.N, Haldimann, A, Wanner, B.L, Zalkin, H, Brennan, R.G. | Deposit date: | 1997-10-04 | Release date: | 1998-05-06 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Structure-based redesign of corepressor specificity of the Escherichia coli purine repressor by substitution of residue 190. Biochemistry, 37, 1998
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6WMT
| F. tularensis RNAPs70-(MglA-SspA)-ppGpp-PigR-iglA DNA complex | Descriptor: | DNA NT-strand, DNA NT-strand downstream, DNA T-strand, ... | Authors: | Travis, B.A, Brennan, R.G, Schumacher, M.A. | Deposit date: | 2020-04-21 | Release date: | 2020-11-11 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (4.43 Å) | Cite: | Structural Basis for Virulence Activation of Francisella tularensis. Mol.Cell, 81, 2021
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1WET
| STRUCTURE OF THE PURR-GUANINE-PURF OPERATOR COMPLEX | Descriptor: | DNA (5'-D(*AP*AP*CP*GP*AP*AP*AP*AP*CP*GP*TP*TP*TP*TP*CP*GP*T )-3'), GUANINE, PROTEIN (PURINE REPRESSOR) | Authors: | Schumacher, M.A, Glasfeld, A, Zalkin, H, Brennan, R.G. | Deposit date: | 1997-04-27 | Release date: | 1997-11-21 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | The X-ray structure of the PurR-guanine-purF operator complex reveals the contributions of complementary electrostatic surfaces and a water-mediated hydrogen bond to corepressor specificity and binding affinity. J.Biol.Chem., 272, 1997
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3MV8
| Crystal Structure of the TK3-Gln55His TCR in complex with HLA-B*3501/HPVG | Descriptor: | Beta-2-microglobulin, HLA class I histocompatibility antigen, B-35 alpha chain, ... | Authors: | Gras, S, Chen, Z, Miles, J.J, Liu, Y.C, Bell, M.J, Sullivan, L.C, Kjer-Nielsen, L, Brennan, R.M, Burrows, J.M, Neller, M.A, Khanna, R, Purcell, A.W, Brooks, A.G, McCluskey, J, Rossjohn, J, Burrows, S.R. | Deposit date: | 2010-05-03 | Release date: | 2010-06-09 | Last modified: | 2011-07-20 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Allelic polymorphism in the T cell receptor and its impact on immune responses J.Exp.Med., 207, 2010
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