5HUU
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![BU of 5huu by Molmil](/molmil-images/mine/5huu) | Structure of Candida albicans trehalose-6-phosphate synthase in complex with UDP and glucose-6-phosphate | 分子名称: | 6-O-phosphono-alpha-D-glucopyranose, Alpha,alpha-trehalose-phosphate synthase [UDP-forming], URIDINE-5'-DIPHOSPHATE | 著者 | Miao, Y, Brennan, R.G. | 登録日 | 2016-01-27 | 公開日 | 2017-05-03 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.37 Å) | 主引用文献 | Structural and In Vivo Studies on Trehalose-6-Phosphate Synthase from Pathogenic Fungi Provide Insights into Its Catalytic Mechanism, Biological Necessity, and Potential for Novel Antifungal Drug Design. MBio, 8, 2017
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5HVM
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![BU of 5hvm by Molmil](/molmil-images/mine/5hvm) | Structure of Aspergillus fumigatus trehalose-6-phosphate synthase A in complex with UDP and validoxylamine A | 分子名称: | (1S,2S,3R,6S)-4-(HYDROXYMETHYL)-6-{[(1S,2S,3S,4R,5R)-2,3,4-TRIHYDROXY-5-(HYDROXYMETHYL)CYCLOHEXYL]AMINO}CYCLOHEX-4-ENE-1,2,3-TRIOL, Alpha,alpha-trehalose-phosphate synthase (UDP-forming), URIDINE-5'-DIPHOSPHATE | 著者 | Miao, Y, Brennan, R.G. | 登録日 | 2016-01-28 | 公開日 | 2017-05-03 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.815 Å) | 主引用文献 | Structural and In Vivo Studies on Trehalose-6-Phosphate Synthase from Pathogenic Fungi Provide Insights into Its Catalytic Mechanism, Biological Necessity, and Potential for Novel Antifungal Drug Design. MBio, 8, 2017
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5HUT
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![BU of 5hut by Molmil](/molmil-images/mine/5hut) | Structure of Candida albicans trehalose-6-phosphate synthase in complex with UDP-glucose | 分子名称: | Alpha,alpha-trehalose-phosphate synthase [UDP-forming], PENTAETHYLENE GLYCOL, SODIUM ION, ... | 著者 | Miao, Y, Brennan, R.G. | 登録日 | 2016-01-27 | 公開日 | 2017-05-03 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Structural and In Vivo Studies on Trehalose-6-Phosphate Synthase from Pathogenic Fungi Provide Insights into Its Catalytic Mechanism, Biological Necessity, and Potential for Novel Antifungal Drug Design. MBio, 8, 2017
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2HQ5
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5HVL
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![BU of 5hvl by Molmil](/molmil-images/mine/5hvl) | Structure of Candida albicans trehalose-6-phosphate synthase in complex with UDP and validoxylamine A | 分子名称: | (1S,2S,3R,6S)-4-(HYDROXYMETHYL)-6-{[(1S,2S,3S,4R,5R)-2,3,4-TRIHYDROXY-5-(HYDROXYMETHYL)CYCLOHEXYL]AMINO}CYCLOHEX-4-ENE-1,2,3-TRIOL, Alpha,alpha-trehalose-phosphate synthase [UDP-forming], SULFATE ION, ... | 著者 | Miao, Y, Brennan, R.G. | 登録日 | 2016-01-28 | 公開日 | 2017-05-03 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (1.796 Å) | 主引用文献 | Structural and In Vivo Studies on Trehalose-6-Phosphate Synthase from Pathogenic Fungi Provide Insights into Its Catalytic Mechanism, Biological Necessity, and Potential for Novel Antifungal Drug Design. MBio, 8, 2017
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2PUG
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![BU of 2pug by Molmil](/molmil-images/mine/2pug) | CRYSTAL STRUCTURE OF THE LACI FAMILY MEMBER, PURR, BOUND TO DNA: MINOR GROOVE BINDING BY ALPHA HELICES | 分子名称: | DNA (5'-D(*TP*AP*CP*GP*CP*AP*AP*AP*CP*GP*TP*TP*TP*GP*CP*GP*T )-3'), HYPOXANTHINE, PROTEIN (PURINE REPRESSOR) | 著者 | Lu, F, Schumacher, M.A, Arvidson, D.N, Haldimann, A, Wanner, B.L, Zalkin, H, Brennan, R.G. | 登録日 | 1997-10-04 | 公開日 | 1998-05-06 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Structure-based redesign of corepressor specificity of the Escherichia coli purine repressor by substitution of residue 190. Biochemistry, 37, 1998
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2H1C
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![BU of 2h1c by Molmil](/molmil-images/mine/2h1c) | Crystal Structure of FitAcB from Neisseria gonorrhoeae | 分子名称: | ACETATE ION, MAGNESIUM ION, SULFATE ION, ... | 著者 | Mattison, K, Wilbur, J.S, So, M, Brennan, R.G. | 登録日 | 2006-05-16 | 公開日 | 2006-09-26 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Structure of FitAB from Neisseria gonorrhoeae bound to DNA reveals a tetramer of toxin-antitoxin heterodimers containing pin domains and ribbon-helix-helix motifs. J.Biol.Chem., 281, 2006
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2H1O
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![BU of 2h1o by Molmil](/molmil-images/mine/2h1o) | Structure of FitAB bound to IR36 DNA fragment | 分子名称: | IR36-strand 1, IR36-strand 2, Trafficking protein A, ... | 著者 | Mattison, K, Wilbur, J.S, So, M, Brennan, R.G. | 登録日 | 2006-05-16 | 公開日 | 2006-09-26 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Structure of FitAB from Neisseria gonorrhoeae bound to DNA reveals a tetramer of toxin-antitoxin heterodimers containing pin domains and ribbon-helix-helix motifs. J.Biol.Chem., 281, 2006
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2PUD
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![BU of 2pud by Molmil](/molmil-images/mine/2pud) | CRYSTAL STRUCTURE OF THE LACI FAMILY MEMBER, PURR, BOUND TO DNA: MINOR GROOVE BINDING BY ALPHA HELICES | 分子名称: | DNA (5'-D(*TP*AP*CP*GP*CP*AP*AP*AP*CP*GP*TP*TP*TP*GP*CP*GP*T )-3'), HYPOXANTHINE, PROTEIN (PURINE REPRESSOR) | 著者 | Schumacher, M.A, Choi, K.Y, Zalkin, H, Brennan, R.G. | 登録日 | 1997-10-04 | 公開日 | 1998-05-06 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Crystal structure of LacI member, PurR, bound to DNA: minor groove binding by alpha helices. Science, 266, 1994
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2PUF
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![BU of 2puf by Molmil](/molmil-images/mine/2puf) | CRYSTAL STRUCTURE OF THE LACI FAMILY MEMBER, PURR, BOUND TO DNA: MINOR GROOVE BINDING BY ALPHA HELICES | 分子名称: | DNA (5'-D(*TP*AP*CP*GP*CP*AP*AP*AP*CP*GP*TP*TP*TP*GP*CP*GP*T )-3'), GUANINE, PROTEIN (PURINE REPRESSOR) | 著者 | Lu, F, Schumacher, M.A, Arvidson, D.N, Haldimann, A, Wanner, B.L, Zalkin, H, Brennan, R.G. | 登録日 | 1997-10-04 | 公開日 | 1998-05-06 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Structure-based redesign of corepressor specificity of the Escherichia coli purine repressor by substitution of residue 190. Biochemistry, 37, 1998
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2PUC
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![BU of 2puc by Molmil](/molmil-images/mine/2puc) | CRYSTAL STRUCTURE OF THE LACI FAMILY MEMBER, PURR, BOUND TO DNA: MINOR GROOVE BINDING BY ALPHA HELICES | 分子名称: | DNA (5'-D(*TP*AP*CP*GP*CP*AP*AP*AP*CP*GP*TP*TP*TP*GP*CP*GP*T )-3'), GUANINE, PROTEIN (PURINE REPRESSOR) | 著者 | Schumacher, M.A, Choi, K.Y, Zalkin, H, Brennan, R.G. | 登録日 | 1997-10-04 | 公開日 | 1998-05-06 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Crystal structure of LacI member, PurR, bound to DNA: minor groove binding by alpha helices. Science, 266, 1994
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1HAB
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![BU of 1hab by Molmil](/molmil-images/mine/1hab) | CROSSLINKED HAEMOGLOBIN | 分子名称: | 4-CARBOXYCINNAMIC ACID, CARBON MONOXIDE, HEMOGLOBIN A, ... | 著者 | Schumacher, M.A, Dixon, M.M, Kluger, R, Jones, R.T, Brennan, R.G. | 登録日 | 1996-03-13 | 公開日 | 1997-11-12 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Allosteric intermediates indicate R2 is the liganded hemoglobin end state. Proc.Natl.Acad.Sci.USA, 94, 1997
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1HAC
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![BU of 1hac by Molmil](/molmil-images/mine/1hac) | CROSSLINKED HAEMOGLOBIN | 分子名称: | 2,6-DICARBOXYNAPHTHALENE, CARBON MONOXIDE, HEMOGLOBIN A, ... | 著者 | Schumacher, M.A, Dixon, M.M, Kluger, R, Jones, R.T, Brennan, R.G. | 登録日 | 1996-03-13 | 公開日 | 1997-11-12 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Allosteric intermediates indicate R2 is the liganded hemoglobin end state. Proc.Natl.Acad.Sci.USA, 94, 1997
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1R8E
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![BU of 1r8e by Molmil](/molmil-images/mine/1r8e) | Crystal Structure of BmrR Bound to DNA at 2.4A Resolution | 分子名称: | 5'-D(*GP*AP*CP*CP*CP*TP*CP*CP*CP*CP*TP*TP*AP*GP*GP*GP*GP*AP*GP*GP*GP*TP*C)-3', GLYCEROL, IMIDAZOLE, ... | 著者 | Newberry, K.J, Brennan, R.G. | 登録日 | 2003-10-23 | 公開日 | 2004-08-17 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | The structural mechanism for transcription activation by MerR family member multidrug transporter activation, N terminus. J.Biol.Chem., 279, 2004
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1R8D
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![BU of 1r8d by Molmil](/molmil-images/mine/1r8d) | Crystal Structure of MtaN Bound to DNA | 分子名称: | 26-MER, SULFATE ION, transcription activator MtaN | 著者 | Newberry, K.J, Brennan, R.G. | 登録日 | 2003-10-23 | 公開日 | 2004-08-17 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | The structural mechanism for transcription activation by MerR family member multidrug transporter activation, N terminus. J.Biol.Chem., 279, 2004
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4Z58
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![BU of 4z58 by Molmil](/molmil-images/mine/4z58) | HipB-O3 20mer complex | 分子名称: | Antitoxin HipB, DNA (5'-D(*TP*TP*AP*TP*CP*CP*GP*CP*TP*CP*TP*AP*CP*GP*GP*GP*AP*TP*AP*A)-3') | 著者 | Min, J, Brennan, R.G, Schumacher, M.A. | 登録日 | 2015-04-02 | 公開日 | 2016-07-06 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Molecular mechanism on hipBA gene regulation. To be published
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3D6Y
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4Z59
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![BU of 4z59 by Molmil](/molmil-images/mine/4z59) | HipB-O4 20mer complex | 分子名称: | Antitoxin HipB, DNA (5'-D(*TP*TP*AP*TP*CP*CP*GP*CP*GP*AP*TP*CP*GP*CP*GP*GP*AP*TP*AP*A)-3') | 著者 | Min, J, Brennan, R.G, Schumacher, M.A. | 登録日 | 2015-04-02 | 公開日 | 2016-07-06 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Molecular mechanism on hipBA gene regulation. To be published
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3D6Z
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3D70
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4Z5D
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![BU of 4z5d by Molmil](/molmil-images/mine/4z5d) | HipB-O4 21mer complex | 分子名称: | Antitoxin HipB, DNA (5'-D(*TP*TP*TP*AP*TP*CP*CP*GP*CP*GP*AP*TP*CP*GP*CP*GP*GP*AP*TP*A)-3'), DNA (5'-D(*TP*TP*TP*AP*TP*CP*CP*GP*CP*GP*AP*TP*CP*GP*CP*GP*GP*AP*TP*AP*A)-3') | 著者 | Min, J, Brennan, R.G, Schumacher, M.A. | 登録日 | 2015-04-02 | 公開日 | 2016-07-06 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | 主引用文献 | Molecular mechanism on hipBA gene regulation. To be published
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3GIB
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1PRU
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![BU of 1pru by Molmil](/molmil-images/mine/1pru) | PURINE REPRESSOR DNA-BINDING DOMAIN DNA BINDING | 分子名称: | PURINE REPRESSOR | 著者 | Nagadoi, A, Morikawa, S, Nakamura, H, Enari, M, Kobayashi, K, Yamamoto, H, Sampei, G, Mizobuchi, K, Schumacher, M.A, Brennan, R.G, Nishimura, Y. | 登録日 | 1995-05-08 | 公開日 | 1996-03-08 | 最終更新日 | 2024-05-01 | 実験手法 | SOLUTION NMR | 主引用文献 | Structural comparison of the free and DNA-bound forms of the purine repressor DNA-binding domain. Structure, 3, 1995
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1PRV
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![BU of 1prv by Molmil](/molmil-images/mine/1prv) | PURINE REPRESSOR DNA-BINDING DOMAIN DNA BINDING | 分子名称: | PURINE REPRESSOR | 著者 | Nagadoi, A, Morikawa, S, Nakamura, H, Enari, M, Kobayashi, K, Yamamoto, H, Sampei, G, Mizobuchi, K, Schumacher, M.A, Brennan, R.G, Nishimura, Y. | 登録日 | 1995-05-08 | 公開日 | 1996-03-08 | 最終更新日 | 2024-05-01 | 実験手法 | SOLUTION NMR | 主引用文献 | Structural comparison of the free and DNA-bound forms of the purine repressor DNA-binding domain. Structure, 3, 1995
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1QQB
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![BU of 1qqb by Molmil](/molmil-images/mine/1qqb) | PURINE REPRESSOR MUTANT-HYPOXANTHINE-PALINDROMIC OPERATOR COMPLEX | 分子名称: | 5'-D(*TP*AP*CP*GP*CP*AP*AP*TP*CP*GP*AP*TP*TP*GP*CP*GP*T)-3', HYPOXANTHINE, PURINE NUCLEOTIDE SYNTHESIS REPRESSOR | 著者 | Glasfeld, A, Koehler, A.N, Schumacher, M.A, Brennan, R.G. | 登録日 | 1999-06-01 | 公開日 | 1999-06-09 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | The role of lysine 55 in determining the specificity of the purine repressor for its operators through minor groove interactions. J.Mol.Biol., 291, 1999
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