2HQ5

Crystal structure of multidrug binding protein QacR from Staphylococcus aureus cocrystallized with compound DB359

Summary for 2HQ5

Related1RPW 1RKW 1JT6 2DTZ
DescriptorHTH-type transcriptional regulator qacR, SULFATE ION (3 entities in total)
Functional Keywordsmultidrug recognition, db359, qacr, multidrug binding protein, transcription
Biological sourceStaphylococcus aureus
Total number of polymer chains4
Total molecular weight93276.97
Authors
Brooks, B.E.,Brennan, R.G. (deposition date: 2006-07-18, release date: 2007-07-17, Last modification date: 2011-07-13)
Primary citation
Brooks, B.E.,Piro, K.M.,Brennan, R.G.
Multidrug-Binding Transcription Factor QacR Binds the Bivalent Aromatic Diamidines DB75 and DB359 in Multiple Positions
J.Am.Chem.Soc., 129:8389-8395, 2007
PubMed: 17567017 (PDB entries with the same primary citation)
DOI: 10.1021/ja072576v
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.8 Å)
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Structure validation

ClashscoreRamachandran outliersSidechain outliersRSRZ outliers221.8%6.8%2.2%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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