2HQ5

Crystal structure of multidrug binding protein QacR from Staphylococcus aureus cocrystallized with compound DB359

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0003700	molecular_function	DNA-binding transcription factor activity
A	0045892	biological_process	negative regulation of DNA-templated transcription
B	0003677	molecular_function	DNA binding
B	0003700	molecular_function	DNA-binding transcription factor activity
B	0045892	biological_process	negative regulation of DNA-templated transcription
D	0003677	molecular_function	DNA binding
D	0003700	molecular_function	DNA-binding transcription factor activity
D	0045892	biological_process	negative regulation of DNA-templated transcription
E	0003677	molecular_function	DNA binding
E	0003700	molecular_function	DNA-binding transcription factor activity
E	0045892	biological_process	negative regulation of DNA-templated transcription

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 B 505

Chain	Residue
B	GLN64
B	GLU90
B	TYR91
D	GLN64
D	LYS67
D	TYR91
D	SO4508

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 D 502

Chain	Residue
D	THR25
D	LYS46
D	THR23
D	THR24

---

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 D 508

Chain	Residue
B	GLN64
B	LYS67
B	TYR91
B	SO4505
D	GLU90
D	TYR91

---

site_id	AC4
Number of Residues	1
Details	BINDING SITE FOR RESIDUE SO4 D 516

Chain	Residue
D	SER187

---

site_id	AC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 A 501

Chain	Residue
A	THR24
A	GLY26

---

site_id	AC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A 517

Chain	Residue
A	SER35
A	LYS36
E	LYS60

---

site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 503

Chain	Residue
A	ASN2
A	LEU3
A	LYS4
A	HIS42

---

site_id	AC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 A 504

Chain	Residue
A	LYS4
A	HIS42
A	HOH518
A	HOH526
E	LYS17

---

site_id	AC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A 506

Chain	Residue
E	ARG76
E	TYR80
E	GLN180

---

site_id	BC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A 507

Chain	Residue
A	HIS128
A	LYS132
A	HOH520

---

site_id	BC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 E 512

Chain	Residue
E	THR24
E	THR25
E	GLY26
E	LYS36

---

site_id	BC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 E 514

Chain	Residue
E	LYS36
E	TYR40
E	THR45
E	LYS46

---

site_id	BC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 E 513

Chain	Residue
E	ASN2
E	LEU3
E	ASN38
E	HIS42
E	HOH520

---

site_id	BC5
Number of Residues	1
Details	BINDING SITE FOR RESIDUE SO4 E 515

Chain	Residue
E	LYS132

---

Functional Information from PROSITE/UniProt

site_id	PS01081
Number of Residues	31
Details	HTH_TETR_1 TetR-type HTH domain signature. GYnatTTgeIvklseSSkGnLYyHFkTKen.L

Chain	Residue	Details
B	GLY19-LEU49

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	76
Details	DNA_BIND: H-T-H motif => ECO:0000255|PROSITE-ProRule:PRU00335

Chain	Residue	Details
B	THR24-PHE43
D	THR24-PHE43
A	THR24-PHE43
E	THR24-PHE43

---