1RKW

CRYSTAL STRUCTURE OF THE MULTIDRUG BINDING TRANSCRIPTIONAL REPRESSOR QACR BOUND TO PENTAMADINE

Summary for 1RKW

Entry DOI	10.2210/pdb1rkw/pdb
Related	1JT6 1JTX 1JTY 1JUM 1JUP 1JUS
Descriptor	Transcriptional regulator qacR, SULFATE ION, 1,5-BIS(4-AMIDINOPHENOXY)PENTANE, ... (4 entities in total)
Functional Keywords	multidrug recognition, pent, qacr, multidrug binding protein, transcription
Biological source	Staphylococcus aureus
Total number of polymer chains	4
Total formula weight	94385.90
Authors	Murray, D.S.,Schumacher, M.A.,Brennan, R.G. (deposition date: 2003-11-23, release date: 2004-06-01, Last modification date: 2023-08-23)
Primary citation	Murray, D.S.,Schumacher, M.A.,Brennan, R.G. Crystal structures of QacR-diamidine complexes reveal additional multidrug-binding modes and a novel mechanism of drug charge neutralization. J.Biol.Chem., 279:14365-14371, 2004 Cited by PubMed: 14726520 DOI: 10.1074/jbc.M313870200 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.62 Å)

Structure validation