1RKW

CRYSTAL STRUCTURE OF THE MULTIDRUG BINDING TRANSCRIPTIONAL REPRESSOR QACR BOUND TO PENTAMADINE

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0003700	molecular_function	DNA-binding transcription factor activity
A	0045892	biological_process	negative regulation of DNA-templated transcription
B	0003677	molecular_function	DNA binding
B	0003700	molecular_function	DNA-binding transcription factor activity
B	0045892	biological_process	negative regulation of DNA-templated transcription
D	0003677	molecular_function	DNA binding
D	0003700	molecular_function	DNA-binding transcription factor activity
D	0045892	biological_process	negative regulation of DNA-templated transcription
E	0003677	molecular_function	DNA binding
E	0003700	molecular_function	DNA-binding transcription factor activity
E	0045892	biological_process	negative regulation of DNA-templated transcription

Functional Information from PDB Data

site_id	AC1
Number of Residues	13
Details	BINDING SITE FOR RESIDUE PNT A 225

Chain	Residue
A	GLU57
A	TYR127
A	ALA153
A	VAL156
A	ASN157
A	LYS60
A	TRP61
A	GLN64
A	TYR82
A	SER86
A	THR89
A	GLU90
A	TYR93

---

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 A 199

Chain	Residue
A	LYS12
A	ILE53
A	ILE56
A	GLU57
A	LYS60

---

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 B 299

Chain	Residue
B	LEU8
B	LYS12
B	ILE53
B	ILE56
B	GLU57

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 399

Chain	Residue
A	LYS4
A	HIS42
A	SO4579
A	HOH723

---

site_id	AC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 D 499

Chain	Residue
D	THR25
D	TYR40
D	THR45
D	LYS46
D	SO4799

---

site_id	AC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 E 599

Chain	Residue
E	THR24
E	THR25
E	GLY26
E	GLU27
E	LYS36

---

site_id	AC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 D 219

Chain	Residue
B	LYS66
D	ASN2
D	LEU3
D	LYS4
D	ASN38
D	HIS42

---

site_id	AC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 D 229

Chain	Residue
D	THR24
D	GLY26

---

site_id	AC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 E 239

Chain	Residue
E	LYS36
E	TYR40
E	THR45
E	LYS46

---

site_id	BC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 699

Chain	Residue
A	VAL29
A	SER35
A	LYS36
E	LYS60

---

site_id	BC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 D 799

Chain	Residue
D	TYR20
D	LYS46
D	GLU105
D	TYR106
D	SO4499

---

site_id	BC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 E 899

Chain	Residue
E	LYS12
E	ILE53
E	ILE56
E	GLU57

---

site_id	BC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 E 999

Chain	Residue
A	LYS36
A	TYR40
E	ASN2
E	ASP5
E	LYS6

---

site_id	BC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 E 249

Chain	Residue
E	LYS4
E	HIS42

---

site_id	BC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 B 259

Chain	Residue
B	GLN64
B	TYR91
D	GLN64
D	TYR91

---

site_id	BC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 B 269

Chain	Residue
B	THR24
B	THR25
B	LYS46

---

site_id	BC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 A 279

Chain	Residue
A	ASN2
A	LEU3
A	LYS4
A	ASN38
A	HIS42

---

site_id	BC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 D 289

Chain	Residue
B	ILE70
B	LYS73
D	HIS164
D	GLN166
E	TYR107

---

site_id	CC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 E 209

Chain	Residue
E	HIS128
E	LYS132

---

site_id	CC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 D 779

Chain	Residue
D	LYS17
D	LYS30
D	GLU33

---

site_id	CC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 D 539

Chain	Residue
A	ASN2
D	TYR107

---

site_id	CC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 D 639

Chain	Residue
D	LYS173
E	ASN143
E	ASP144
E	ALA147

---

site_id	CC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 A 579

Chain	Residue
A	PHE43
A	GLU52
A	SO4399
A	LYS4
A	HIS42

---

Functional Information from PROSITE/UniProt

site_id	PS01081
Number of Residues	31
Details	HTH_TETR_1 TetR-type HTH domain signature. GYnatTTgeIvklseSSkGnLYyHFkTKen.L

Chain	Residue	Details
B	GLY19-LEU49

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	76
Details	DNA binding: {"description":"H-T-H motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU00335","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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