3NA4
 
 | | D53P beta-2 microglobulin mutant | | Descriptor: | 2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, Beta-2-microglobulin | | Authors: | Azinas, S, Ricagno, S, Bolognesi, M. | | Deposit date: | 2010-06-01 | | Release date: | 2011-06-01 | | Last modified: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | D-strand perturbation and amyloid propensity in beta-2 microglobulin
Febs J., 278, 2011
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4FXL
 | | Crystal structure of the D76N Beta-2 Microglobulin mutant | | Descriptor: | ACETATE ION, Beta-2-microglobulin, DI(HYDROXYETHYL)ETHER, ... | | Authors: | Ricagno, S, Bellotti, V, Pepys, M.B, Stoppini, M, Bolognesi, M. | | Deposit date: | 2012-07-03 | | Release date: | 2012-08-15 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (1.4 Å) | | Cite: | Hereditary systemic amyloidosis due to Asp76Asn variant beta-2-microglobulin.
N.Engl.J.Med., 366, 2012
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2BJD
 | | Sulfolobus Solfataricus Acylphosphatase. Triclinic space group | | Descriptor: | ACYLPHOSPHATASE, CADMIUM ION, CHLORIDE ION, ... | | Authors: | Rosano, C, Zuccotti, S, Bolognesi, M. | | Deposit date: | 2005-02-02 | | Release date: | 2005-11-23 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (1.27 Å) | | Cite: | Structure, Conformational Stability, and Enzymatic Properties of Acylphosphatase from the Hyperthermophile Sulfolobus Solfataricus.
Proteins: Struct., Funct., Bioinf., 62, 2006
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7ZIR
 | | Cryo-EM structure of hnRNPDL amyloid fibrils | | Descriptor: | Heterogeneous nuclear ribonucleoprotein D-like | | Authors: | Garcia-Pardo, J, Chaves-Sanjuan, A, Bartolome-Nafria, A, Gil-Garcia, M, Visentin, C, Bolognesi, M, Ricagno, S, Ventura, S. | | Deposit date: | 2022-04-08 | | Release date: | 2022-12-28 | | Last modified: | 2023-12-13 | | Method: | ELECTRON MICROSCOPY (2.5 Å) | | Cite: | Cryo-EM structure of hnRNPDL-2 fibrils, a functional amyloid associated with limb-girdle muscular dystrophy D3.
Nat Commun, 14, 2023
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8A11
 | | Cryo-EM structure of the Human SHMT1-RNA complex | | Descriptor: | PYRIDOXAL-5'-PHOSPHATE, Serine hydroxymethyltransferase, cytosolic | | Authors: | Spizzichino, S, Marabelli, C, Bharadwaj, A, Jakobi, A.J, Chaves-Sanjuan, A, Giardina, G, Bolognesi, M, Cutruzzola, F. | | Deposit date: | 2022-05-30 | | Release date: | 2023-06-14 | | Last modified: | 2024-07-24 | | Method: | ELECTRON MICROSCOPY (3.52 Å) | | Cite: | Structure-based mechanism of riboregulation of the metabolic enzyme SHMT1.
Mol.Cell, 2024
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4EC4
 | | XIAP-BIR3 in complex with a potent divalent Smac mimetic | | Descriptor: | (3S,6S,7S,9aS,3'S,6'S,7'S,9a'S)-N,N'-(benzene-1,4-diylbis{butane-4,1-diyl-1H-1,2,3-triazole-1,4-diyl[(S)-phenylmethanediyl]})bis[7-(hydroxymethyl)-6-{[(2S)-2-(methylamino)butanoyl]amino}-5-oxooctahydro-1H-pyrrolo[1,2-a]azepine-3-carboxamide], 3,6,9,12,15,18-HEXAOXAICOSANE-1,20-DIOL, Baculoviral IAP repeat-containing protein 4, ... | | Authors: | Mastrangelo, E, Cossu, F, Bolognesi, M, Milani, M. | | Deposit date: | 2012-03-26 | | Release date: | 2012-12-05 | | Last modified: | 2024-10-09 | | Method: | X-RAY DIFFRACTION (3.3 Å) | | Cite: | Structural insight into inhibitor of apoptosis proteins recognition by a potent divalent smac-mimetic.
Plos One, 7, 2012
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4EB9
 | | cIAP1-BIR3 in complex with a divalent Smac mimetic | | Descriptor: | (3S,6S,7S,9aS,3'S,6'S,7'S,9a'S)-N,N'-(benzene-1,4-diylbis{butane-4,1-diyl-1H-1,2,3-triazole-1,4-diyl[(S)-phenylmethanediyl]})bis[7-(hydroxymethyl)-6-{[(2S)-2-(methylamino)butanoyl]amino}-5-oxooctahydro-1H-pyrrolo[1,2-a]azepine-3-carboxamide], Baculoviral IAP repeat-containing protein 2, ZINC ION | | Authors: | Cossu, F, Mastrangelo, E, Bolognesi, M, Milani, M. | | Deposit date: | 2012-03-23 | | Release date: | 2012-12-05 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Structural insight into inhibitor of apoptosis proteins recognition by a potent divalent smac-mimetic.
Plos One, 7, 2012
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3QZZ
 | | 3D Structure of Ferric Methanosarcina Acetivorans Protoglobin Y61W mutant in Aquomet form | | Descriptor: | Methanosarcina acetivorans protoglobin, PROTOPORPHYRIN IX CONTAINING FE | | Authors: | Pesce, A, Tilleman, L, Dewilde, S, Ascenzi, P, Coletta, M, Ciaccio, C, Bruno, S, Moens, L, Bolognesi, M, Nardini, M. | | Deposit date: | 2011-03-07 | | Release date: | 2011-06-08 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Structural heterogeneity and ligand gating in ferric methanosarcina acetivorans protoglobin mutants.
Iubmb Life, 63, 2011
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3QZX
 | | 3D Structure of ferric methanosarcina acetivorans protoglobin Y61A mutant with unknown ligand | | Descriptor: | GLYCEROL, Methanosarcina acetivorans protoglobin, PHOSPHATE ION, ... | | Authors: | Pesce, A, Tilleman, L, Dewilde, S, Ascenzi, P, Coletta, M, Ciaccio, C, Bruno, S, Moens, L, Bolognesi, M, Nardini, M. | | Deposit date: | 2011-03-07 | | Release date: | 2011-06-08 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (1.3 Å) | | Cite: | Structural heterogeneity and ligand gating in ferric methanosarcina acetivorans protoglobin mutants.
Iubmb Life, 63, 2011
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3R0G
 | | 3D Structure of Ferric Methanosarcina Acetivorans Protoglobin I149F mutant in Aquomet form | | Descriptor: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, GLYCEROL, ISOPROPYL ALCOHOL, ... | | Authors: | Pesce, A, Tilleman, L, Dewilde, S, Ascenzi, P, Coletta, M, Ciaccio, C, Bruno, S, Moens, L, Bolognesi, M, Nardini, M. | | Deposit date: | 2011-03-08 | | Release date: | 2011-06-08 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Structural heterogeneity and ligand gating in ferric methanosarcina acetivorans protoglobin mutants.
Iubmb Life, 63, 2011
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2OK7
 | | Ferredoxin-NADP+ reductase from Plasmodium falciparum with 2'P-AMP | | Descriptor: | ADENOSINE-2'-5'-DIPHOSPHATE, FLAVIN-ADENINE DINUCLEOTIDE, Putative ferredoxin--NADP reductase, ... | | Authors: | Milani, M, Mastrangelo, E, Bolognesi, M. | | Deposit date: | 2007-01-16 | | Release date: | 2007-02-13 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Ferredoxin-NADP(+) Reductase from Plasmodium falciparum Undergoes NADP(+)-dependent Dimerization and Inactivation: Functional and Crystallographic Analysis.
J.Mol.Biol., 367, 2007
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2OK8
 | | Ferredoxin-NADP+ reductase from Plasmodium falciparum | | Descriptor: | CITRATE ANION, FLAVIN-ADENINE DINUCLEOTIDE, Putative ferredoxin--NADP reductase | | Authors: | Milani, M, Mastrangelo, E, Bolognesi, M. | | Deposit date: | 2007-01-16 | | Release date: | 2007-02-13 | | Last modified: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Ferredoxin-NADP(+) Reductase from Plasmodium falciparum Undergoes NADP(+)-dependent Dimerization and Inactivation: Functional and Crystallographic Analysis.
J.Mol.Biol., 367, 2007
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2OXT
 | | Crystal structure of Meaban virus nucleoside-2'-O-methyltransferase | | Descriptor: | NUCLEOSIDE-2'-O-METHYLTRANSFERASE, S-ADENOSYLMETHIONINE | | Authors: | Mastrangelo, E, Milani, M, Bollati, M, Bolognesi, M. | | Deposit date: | 2007-02-21 | | Release date: | 2007-05-15 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Structural bases for substrate recognition and activity in Meaban virus nucleoside-2'-O-methyltransferase
Protein Sci., 16, 2007
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2C0K
 | | The structure of hemoglobin from the botfly Gasterophilus intestinalis | | Descriptor: | HEMOGLOBIN, OXYGEN MOLECULE, PROTOPORPHYRIN IX CONTAINING FE | | Authors: | Pesce, A, Nardini, M, Dewilde, S, Hoogewijs, D, Ascenzi, P, Moens, L, Bolognesi, M. | | Deposit date: | 2005-09-05 | | Release date: | 2005-11-09 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Modulation of Oxygen Binding to Insect Hemoglobins: The Structure of Hemoglobin from the Botfly Gasterophilus Intestinalis.
Protein Sci., 14, 2005
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2BK9
 | | Drosophila Melanogaster globin | | Descriptor: | 3-CYCLOHEXYL-1-PROPYLSULFONIC ACID, CG9734-PA, CHLORIDE ION, ... | | Authors: | de Sanctis, D, Dewilde, S, Pesce, A, Moens, L, Ascenzi, P, Hankeln, T, Burmester, T, Ponassi, M, Nardini, M, Bolognesi, M. | | Deposit date: | 2005-02-14 | | Release date: | 2005-05-20 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (1.2 Å) | | Cite: | Bishistidyl Heme Hexacoordination, a Key Structural Property in Drosophila Melanogaster Hemoglobin
J.Biol.Chem., 280, 2005
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1Y9O
 | | 1H NMR Structure of Acylphosphatase from the hyperthermophile Sulfolobus Solfataricus | | Descriptor: | Acylphosphatase | | Authors: | Corazza, A, Rosano, C, Pagano, K, Alverdi, V, Esposito, G, Capanni, C, Bemporad, F, Plakoutsi, G, Stefani, M, Chiti, F, Zuccotti, S, Bolognesi, M, Viglino, P. | | Deposit date: | 2004-12-16 | | Release date: | 2005-11-29 | | Last modified: | 2024-05-29 | | Method: | SOLUTION NMR | | Cite: | Structure, conformational stability, and enzymatic properties of acylphosphatase from the hyperthermophile Sulfolobus solfataricus
Proteins, 62, 2006
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5GDS
 | | HIRUNORMS ARE TRUE HIRUDIN MIMETICS. THE CRYSTAL STRUCTURE OF HUMAN ALPHA-THROMBIN:HIRUNORM V COMPLEX | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, ALPHA-THROMBIN, HIRUNORM V | | Authors: | De Simone, G, Lombardi, A, Galdiero, S, Nastri, F, Della Morte, R, Staiano, N, Pedone, C, Bolognesi, M, Pavone, V. | | Deposit date: | 1997-07-17 | | Release date: | 1998-01-21 | | Last modified: | 2023-08-09 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Hirunorms are true hirudin mimetics. The crystal structure of human alpha-thrombin-hirunorm V complex.
Protein Sci., 7, 1998
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1VHB
 | | BACTERIAL DIMERIC HEMOGLOBIN FROM VITREOSCILLA STERCORARIA | | Descriptor: | HEMOGLOBIN, PROTOPORPHYRIN IX CONTAINING FE | | Authors: | Tarricone, C, Galizzi, A, Coda, A, Ascenzi, P, Bolognesi, M. | | Deposit date: | 1997-02-19 | | Release date: | 1998-02-25 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (1.83 Å) | | Cite: | Unusual structure of the oxygen-binding site in the dimeric bacterial hemoglobin from Vitreoscilla sp.
Structure, 5, 1997
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1YIO
 | | Crystallographic structure of response regulator StyR from Pseudomonas fluorescens | | Descriptor: | MAGNESIUM ION, MERCURY (II) ION, response regulatory protein | | Authors: | Milani, M, Leoni, L, Rampioni, G, Zennaro, E, Ascenzi, P, Bolognesi, M. | | Deposit date: | 2005-01-12 | | Release date: | 2005-09-27 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | An Active-like Structure in the Unphosphorylated StyR Response Regulator Suggests a Phosphorylation- Dependent Allosteric Activation Mechanism
STRUCTURE, 13, 2005
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3JQP
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3JQR
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3JQQ
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1ZN2
 | | Low Resolution Structure of Response Regulator StyR | | Descriptor: | MAGNESIUM ION, response regulatory protein | | Authors: | Milani, M, Leoni, L, Rampioni, G, Zennaro, E, Ascenzi, P, Bolognesi, M. | | Deposit date: | 2005-05-11 | | Release date: | 2005-09-27 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (2.91 Å) | | Cite: | An Active-like Structure in the Unphosphorylated StyR Response Regulator Suggests a Phosphorylation- Dependent Allosteric Activation Mechanism.
STRUCTURE, 13, 2005
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5CKA
 | | Human beta-2 microglobulin double mutant W60G-N83V | | Descriptor: | ACETATE ION, Beta-2-microglobulin, DI(HYDROXYETHYL)ETHER, ... | | Authors: | Sala, B.M, De Rosa, M, Bolognesi, M, Ricagno, S. | | Deposit date: | 2015-07-15 | | Release date: | 2016-05-18 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Rational design of mutations that change the aggregation rate of a protein while maintaining its native structure and stability.
Sci Rep, 6, 2016
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5CKG
 | | Human beta-2 microglobulin mutant V85E | | Descriptor: | ACETATE ION, Beta-2-microglobulin, GLYCEROL | | Authors: | Sala, B.M, De Rosa, M, Bolognesi, M, Ricagno, S. | | Deposit date: | 2015-07-15 | | Release date: | 2016-05-18 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (1.75 Å) | | Cite: | Rational design of mutations that change the aggregation rate of a protein while maintaining its native structure and stability.
Sci Rep, 6, 2016
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