4EC4

XIAP-BIR3 in complex with a potent divalent Smac mimetic

Summary for 4EC4

• Entry DOI: 10.2210/pdb4ec4/pdb
• Related: 4EB9
• Descriptor: Baculoviral IAP repeat-containing protein 4, ZINC ION, (3S,6S,7S,9aS,3'S,6'S,7'S,9a'S)-N,N'-(benzene-1,4-diylbis{butane-4,1-diyl-1H-1,2,3-triazole-1,4-diyl[(S)-phenylmethanediyl]})bis[7-(hydroxymethyl)-6-{[(2S)-2-(methylamino)butanoyl]amino}-5-oxooctahydro-1H-pyrrolo[1,2-a]azepine-3-carboxamide], ... (6 entities in total)
• Functional Keywords: zinc finger, apoptosis inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm: P98170
• Total number of polymer chains: 10
• Total formula weight: 149595.95

Authors

Mastrangelo, E.,Cossu, F.,Bolognesi, M.,Milani, M. (deposition date: 2012-03-26, release date: 2012-12-05, Last modification date: 2023-09-13)

• Primary citation: Cossu, F.,Milani, M.,Vachette, P.,Malvezzi, F.,Grassi, S.,Lecis, D.,Delia, D.,Drago, C.,Seneci, P.,Bolognesi, M.,Mastrangelo, E.; Structural insight into inhibitor of apoptosis proteins recognition by a potent divalent smac-mimetic.; Plos One, 7:e49527-e49527, 2012; PubMed: 23166698; DOI: 10.1371/journal.pone.0049527

Experimental method

X-RAY DIFFRACTION (3.3 Å)