8A11

Cryo-EM structure of the Human SHMT1-RNA complex

Summary for 8A11

Entry DOI	10.2210/pdb8a11/pdb
EMDB information	15065
Descriptor	Serine hydroxymethyltransferase, cytosolic, PYRIDOXAL-5'-PHOSPHATE (2 entities in total)
Functional Keywords	riboregulation, metabolism, 1 carbon metablism, moonlighting protein, rna binding protein, transferase
Biological source	Homo sapiens (human)
Total number of polymer chains	4
Total formula weight	214480.61
Authors	Spizzichino, S.,Marabelli, C.,Bharadwaj, A.,Jakobi, A.J.,Chaves-Sanjuan, A.,Giardina, G.,Bolognesi, M.,Cutruzzola, F. (deposition date: 2022-05-30, release date: 2023-06-14, Last modification date: 2024-07-24)
Primary citation	Spizzichino, S.,Di Fonzo, F.,Marabelli, C.,Tramonti, A.,Chaves-Sanjuan, A.,Parroni, A.,Boumis, G.,Liberati, F.R.,Paone, A.,Montemiglio, L.C.,Ardini, M.,Jakobi, A.J.,Bharadwaj, A.,Swuec, P.,Tartaglia, G.G.,Paiardini, A.,Contestabile, R.,Mai, A.,Rotili, D.,Fiorentino, F.,Macone, A.,Giorgi, A.,Tria, G.,Rinaldo, S.,Bolognesi, M.,Giardina, G.,Cutruzzola, F. Structure-based mechanism of riboregulation of the metabolic enzyme SHMT1. Mol.Cell, 2024 Cited by PubMed: 38996576 DOI: 10.1016/j.molcel.2024.06.016 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.52 Å)

Structure validation