8A11

Cryo-EM structure of the Human SHMT1-RNA complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000900	molecular_function	mRNA regulatory element binding translation repressor activity
A	0004372	molecular_function	glycine hydroxymethyltransferase activity
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005829	cellular_component	cytosol
A	0006231	biological_process	dTMP biosynthetic process
A	0006544	biological_process	glycine metabolic process
A	0006563	biological_process	L-serine metabolic process
A	0006565	biological_process	L-serine catabolic process
A	0006730	biological_process	one-carbon metabolic process
A	0009113	biological_process	purine nucleobase biosynthetic process
A	0016740	molecular_function	transferase activity
A	0016832	molecular_function	aldehyde-lyase activity
A	0017148	biological_process	negative regulation of translation
A	0019264	biological_process	glycine biosynthetic process from serine
A	0030170	molecular_function	pyridoxal phosphate binding
A	0035999	biological_process	tetrahydrofolate interconversion
A	0036094	molecular_function	small molecule binding
A	0042802	molecular_function	identical protein binding
A	0042803	molecular_function	protein homodimerization activity
A	0045329	biological_process	carnitine biosynthetic process
A	0046653	biological_process	tetrahydrofolate metabolic process
A	0046655	biological_process	folic acid metabolic process
A	0048027	molecular_function	mRNA 5'-UTR binding
A	0051289	biological_process	protein homotetramerization
A	0070062	cellular_component	extracellular exosome
A	0070905	molecular_function	serine binding
A	1904482	biological_process	cellular response to tetrahydrofolate
A	1990830	biological_process	cellular response to leukemia inhibitory factor
B	0000900	molecular_function	mRNA regulatory element binding translation repressor activity
B	0004372	molecular_function	glycine hydroxymethyltransferase activity
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005737	cellular_component	cytoplasm
B	0005739	cellular_component	mitochondrion
B	0005829	cellular_component	cytosol
B	0006231	biological_process	dTMP biosynthetic process
B	0006544	biological_process	glycine metabolic process
B	0006563	biological_process	L-serine metabolic process
B	0006565	biological_process	L-serine catabolic process
B	0006730	biological_process	one-carbon metabolic process
B	0009113	biological_process	purine nucleobase biosynthetic process
B	0016740	molecular_function	transferase activity
B	0016832	molecular_function	aldehyde-lyase activity
B	0017148	biological_process	negative regulation of translation
B	0019264	biological_process	glycine biosynthetic process from serine
B	0030170	molecular_function	pyridoxal phosphate binding
B	0035999	biological_process	tetrahydrofolate interconversion
B	0036094	molecular_function	small molecule binding
B	0042802	molecular_function	identical protein binding
B	0042803	molecular_function	protein homodimerization activity
B	0045329	biological_process	carnitine biosynthetic process
B	0046653	biological_process	tetrahydrofolate metabolic process
B	0046655	biological_process	folic acid metabolic process
B	0048027	molecular_function	mRNA 5'-UTR binding
B	0051289	biological_process	protein homotetramerization
B	0070062	cellular_component	extracellular exosome
B	0070905	molecular_function	serine binding
B	1904482	biological_process	cellular response to tetrahydrofolate
B	1990830	biological_process	cellular response to leukemia inhibitory factor
C	0000900	molecular_function	mRNA regulatory element binding translation repressor activity
C	0004372	molecular_function	glycine hydroxymethyltransferase activity
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005737	cellular_component	cytoplasm
C	0005739	cellular_component	mitochondrion
C	0005829	cellular_component	cytosol
C	0006231	biological_process	dTMP biosynthetic process
C	0006544	biological_process	glycine metabolic process
C	0006563	biological_process	L-serine metabolic process
C	0006565	biological_process	L-serine catabolic process
C	0006730	biological_process	one-carbon metabolic process
C	0009113	biological_process	purine nucleobase biosynthetic process
C	0016740	molecular_function	transferase activity
C	0016832	molecular_function	aldehyde-lyase activity
C	0017148	biological_process	negative regulation of translation
C	0019264	biological_process	glycine biosynthetic process from serine
C	0030170	molecular_function	pyridoxal phosphate binding
C	0035999	biological_process	tetrahydrofolate interconversion
C	0036094	molecular_function	small molecule binding
C	0042802	molecular_function	identical protein binding
C	0042803	molecular_function	protein homodimerization activity
C	0045329	biological_process	carnitine biosynthetic process
C	0046653	biological_process	tetrahydrofolate metabolic process
C	0046655	biological_process	folic acid metabolic process
C	0048027	molecular_function	mRNA 5'-UTR binding
C	0051289	biological_process	protein homotetramerization
C	0070062	cellular_component	extracellular exosome
C	0070905	molecular_function	serine binding
C	1904482	biological_process	cellular response to tetrahydrofolate
C	1990830	biological_process	cellular response to leukemia inhibitory factor
D	0000900	molecular_function	mRNA regulatory element binding translation repressor activity
D	0004372	molecular_function	glycine hydroxymethyltransferase activity
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005737	cellular_component	cytoplasm
D	0005739	cellular_component	mitochondrion
D	0005829	cellular_component	cytosol
D	0006231	biological_process	dTMP biosynthetic process
D	0006544	biological_process	glycine metabolic process
D	0006563	biological_process	L-serine metabolic process
D	0006565	biological_process	L-serine catabolic process
D	0006730	biological_process	one-carbon metabolic process
D	0009113	biological_process	purine nucleobase biosynthetic process
D	0016740	molecular_function	transferase activity
D	0016832	molecular_function	aldehyde-lyase activity
D	0017148	biological_process	negative regulation of translation
D	0019264	biological_process	glycine biosynthetic process from serine
D	0030170	molecular_function	pyridoxal phosphate binding
D	0035999	biological_process	tetrahydrofolate interconversion
D	0036094	molecular_function	small molecule binding
D	0042802	molecular_function	identical protein binding
D	0042803	molecular_function	protein homodimerization activity
D	0045329	biological_process	carnitine biosynthetic process
D	0046653	biological_process	tetrahydrofolate metabolic process
D	0046655	biological_process	folic acid metabolic process
D	0048027	molecular_function	mRNA 5'-UTR binding
D	0051289	biological_process	protein homotetramerization
D	0070062	cellular_component	extracellular exosome
D	0070905	molecular_function	serine binding
D	1904482	biological_process	cellular response to tetrahydrofolate
D	1990830	biological_process	cellular response to leukemia inhibitory factor

Functional Information from PROSITE/UniProt

site_id	PS00096
Number of Residues	17
Details	SHMT Serine hydroxymethyltransferase pyridoxal-phosphate attachment site. HVvTTTTHKTLrGCRAG

Chain	Residue	Details
A	HIS249-GLY265

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	MOD_RES: N6-(pyridoxal phosphate)lysine => ECO:0000269|PubMed:9753690, ECO:0007744|PDB:1BJ4

Chain	Residue	Details
A	LYS257
B	LYS257
C	LYS257
D	LYS257

---