5IQV
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![BU of 5iqv by Molmil](/molmil-images/mine/5iqv) | WelO5 bound to Fe, Cl, 2-oxoglutarate, 12-epifischerindole U, and nitric oxide | Descriptor: | (6aS,9R,10R,10aS)-9-ethyl-10-isocyano-6,6,9-trimethyl-5,6,6a,7,8,9,10,10a-octahydroindeno[2,1-b]indole, 2-OXOGLUTARIC ACID, CHLORIDE ION, ... | Authors: | Mitchell, A.J, Boal, A.K. | Deposit date: | 2016-03-11 | Release date: | 2016-06-29 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structural basis for halogenation by iron- and 2-oxo-glutarate-dependent enzyme WelO5. Nat.Chem.Biol., 12, 2016
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6P5Q
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![BU of 6p5q by Molmil](/molmil-images/mine/6p5q) | X-ray structure of Fe(II)-soaked UndA bound to lauric acid | Descriptor: | FE (III) ION, GLYCEROL, LAURIC ACID, ... | Authors: | Rajakovich, L.J, Mitchell, A.J, Boal, A.K. | Deposit date: | 2019-05-30 | Release date: | 2019-09-18 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.86 Å) | Cite: | Substrate-Triggered Formation of a Peroxo-Fe2(III/III) Intermediate during Fatty Acid Decarboxylation by UndA. J.Am.Chem.Soc., 141, 2019
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5IQT
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![BU of 5iqt by Molmil](/molmil-images/mine/5iqt) | WelO5 bound to Fe(II), Cl, 2-oxoglutarate, and 12-epifischerindole U | Descriptor: | (6aS,9R,10R,10aS)-9-ethyl-10-isocyano-6,6,9-trimethyl-5,6,6a,7,8,9,10,10a-octahydroindeno[2,1-b]indole, 2-OXOGLUTARIC ACID, CHLORIDE ION, ... | Authors: | Mitchell, A.J, Boal, A.K. | Deposit date: | 2016-03-11 | Release date: | 2016-06-29 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structural basis for halogenation by iron- and 2-oxo-glutarate-dependent enzyme WelO5. Nat.Chem.Biol., 12, 2016
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5IQU
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![BU of 5iqu by Molmil](/molmil-images/mine/5iqu) | WelO5 G166D variant bound to Fe(II), 2-oxoglutarate, and 12-epifischerindole U | Descriptor: | (6aS,9R,10R,10aS)-9-ethyl-10-isocyano-6,6,9-trimethyl-5,6,6a,7,8,9,10,10a-octahydroindeno[2,1-b]indole, 2-OXOGLUTARIC ACID, FE (II) ION, ... | Authors: | Mitchell, A.J, Maggiolo, A.O, Boal, A.K. | Deposit date: | 2016-03-11 | Release date: | 2016-06-29 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.51 Å) | Cite: | Structural basis for halogenation by iron- and 2-oxo-glutarate-dependent enzyme WelO5. Nat.Chem.Biol., 12, 2016
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5IQS
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![BU of 5iqs by Molmil](/molmil-images/mine/5iqs) | WelO5 bound to Fe(II), Cl, and 2-oxoglutarate | Descriptor: | 2-OXOGLUTARIC ACID, CHLORIDE ION, FE (II) ION, ... | Authors: | Mitchell, A.J, Ananth, N, Boal, A.K. | Deposit date: | 2016-03-11 | Release date: | 2016-06-29 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural basis for halogenation by iron- and 2-oxo-glutarate-dependent enzyme WelO5. Nat.Chem.Biol., 12, 2016
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5HR6
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![BU of 5hr6 by Molmil](/molmil-images/mine/5hr6) | X-ray crystal structure of C118A RlmN with cross-linked tRNA purified from Escherichia coli | Descriptor: | 5'-DEOXYADENOSINE, IRON/SULFUR CLUSTER, MAGNESIUM ION, ... | Authors: | Schwalm, E.L, Grove, T.L, Booker, S.J, Boal, A.K. | Deposit date: | 2016-01-22 | Release date: | 2016-04-13 | Last modified: | 2016-04-27 | Method: | X-RAY DIFFRACTION (2.88 Å) | Cite: | Crystallographic capture of a radical S-adenosylmethionine enzyme in the act of modifying tRNA. Science, 352, 2016
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6M9S
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![BU of 6m9s by Molmil](/molmil-images/mine/6m9s) | Crystal structure of SeMet SznF from Streptomyces achromogenes var. streptozoticus NRRL 2697 | Descriptor: | FE (III) ION, GLYCEROL, ISOPROPYL ALCOHOL, ... | Authors: | Rohac, R, Mitchell, A.J, Boal, A.K. | Deposit date: | 2018-08-24 | Release date: | 2019-02-06 | Last modified: | 2020-01-01 | Method: | X-RAY DIFFRACTION (2.08 Å) | Cite: | An N-nitrosating metalloenzyme constructs the pharmacophore of streptozotocin. Nature, 566, 2019
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6M9R
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6NPC
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![BU of 6npc by Molmil](/molmil-images/mine/6npc) | X-ray crystal structure of TmpA, 2-trimethylaminoethylphosphonate hydroxylase, with Fe, 2OG, and 2-trimethylaminoethylphosphonate | Descriptor: | 2-OXOGLUTARIC ACID, FE (II) ION, N,N,N-trimethyl-2-phosphonoethan-1-aminium, ... | Authors: | Rajakovich, L.J, Mitchell, A.J, Boal, A.K. | Deposit date: | 2019-01-17 | Release date: | 2019-03-06 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | A New Microbial Pathway for Organophosphonate Degradation Catalyzed by Two Previously Misannotated Non-Heme-Iron Oxygenases. Biochemistry, 58, 2019
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6NPD
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![BU of 6npd by Molmil](/molmil-images/mine/6npd) | X-ray crystal structure of TmpA, 2-trimethylaminoethylphosphonate hydroxylase, with Fe, 2OG, and (R)-1-hydroxy-2-trimethylaminoethylphosphonate | Descriptor: | (2R)-2-hydroxy-N,N,N-trimethyl-2-phosphonoethan-1-aminium, FE (II) ION, TmpA, ... | Authors: | Rajakovich, L.J, Mitchell, A.J, Boal, A.K. | Deposit date: | 2019-01-17 | Release date: | 2019-03-06 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.78 Å) | Cite: | A New Microbial Pathway for Organophosphonate Degradation Catalyzed by Two Previously Misannotated Non-Heme-Iron Oxygenases. Biochemistry, 58, 2019
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6NPA
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![BU of 6npa by Molmil](/molmil-images/mine/6npa) | X-ray crystal structure of TmpB, (R)-1-hydroxy-2-trimethylaminoethylphosphonate oxygenase, with (R)-1-hydroxy-2-trimethylaminoethylphosphonate | Descriptor: | (2R)-2-hydroxy-N,N,N-trimethyl-2-phosphonoethan-1-aminium, FE (II) ION, FE (III) ION, ... | Authors: | Rajakovich, L.J, Mitchell, A.J, Boal, A.K. | Deposit date: | 2019-01-17 | Release date: | 2019-03-06 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.73 Å) | Cite: | A New Microbial Pathway for Organophosphonate Degradation Catalyzed by Two Previously Misannotated Non-Heme-Iron Oxygenases. Biochemistry, 58, 2019
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6NPB
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![BU of 6npb by Molmil](/molmil-images/mine/6npb) | X-ray crystal structure of TmpA, 2-trimethylaminoethylphosphonate hydroxylase, with Fe and 2OG | Descriptor: | 2-OXOGLUTARIC ACID, FE (II) ION, SULFATE ION, ... | Authors: | Rajakovich, L.J, Mitchell, A.J, Boal, A.K. | Deposit date: | 2019-01-17 | Release date: | 2019-03-06 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.73 Å) | Cite: | A New Microbial Pathway for Organophosphonate Degradation Catalyzed by Two Previously Misannotated Non-Heme-Iron Oxygenases. Biochemistry, 58, 2019
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6MP8
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![BU of 6mp8 by Molmil](/molmil-images/mine/6mp8) | X-ray crystal structure of VioC bound to Fe(II), D-arginine, and 2-oxoglutarate | Descriptor: | 2-OXOGLUTARIC ACID, Alpha-ketoglutarate-dependent L-arginine hydroxylase, D-ARGININE, ... | Authors: | Dunham, N.P, Boal, A.K. | Deposit date: | 2018-10-05 | Release date: | 2018-11-21 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.89 Å) | Cite: | alpha-Amine Desaturation of d-Arginine by the Iron(II)- and 2-(Oxo)glutarate-Dependent l-Arginine 3-Hydroxylase, VioC. Biochemistry, 57, 2018
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6MP9
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![BU of 6mp9 by Molmil](/molmil-images/mine/6mp9) | X-ray crystal structure of VioC bound to Fe(II), 2-oxo-5-guanidinopentanoic acid, and succinate | Descriptor: | 5-carbamimidamido-2-oxopentanoic acid, Alpha-ketoglutarate-dependent L-arginine hydroxylase, FE (II) ION, ... | Authors: | Dunham, N.P, Boal, A.K. | Deposit date: | 2018-10-05 | Release date: | 2018-11-21 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.89 Å) | Cite: | alpha-Amine Desaturation of d-Arginine by the Iron(II)- and 2-(Oxo)glutarate-Dependent l-Arginine 3-Hydroxylase, VioC. Biochemistry, 57, 2018
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5VNP
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4D8F
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![BU of 4d8f by Molmil](/molmil-images/mine/4d8f) | Chlamydia trachomatis NrdB with a Mn/Fe cofactor (procedure 1 - high Mn) | Descriptor: | ACETIC ACID, FE (III) ION, MANGANESE (II) ION, ... | Authors: | Dassama, L.M.K, Boal, A.K, Krebs, C, Rosenzweig, A.C, Bollinger Jr, J.M. | Deposit date: | 2012-01-10 | Release date: | 2012-02-15 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Evidence that the beta subunit of Chlamydia trachomatis ribonucleotide reductase is active with the manganese ion of its manganese(IV)/iron(III) cofactor in site 1. J.Am.Chem.Soc., 134, 2012
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4D8G
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![BU of 4d8g by Molmil](/molmil-images/mine/4d8g) | Chlamydia trachomatis NrdB with a Mn/Fe cofactor (procedure 2 - low Mn) | Descriptor: | FE (III) ION, MANGANESE (II) ION, Ribonucleoside-diphosphate reductase subunit beta | Authors: | Dassama, L.M.K, Boal, A.K, Krebs, C, Rosenzweig, A.C, Bollinger Jr, J.M. | Deposit date: | 2012-01-10 | Release date: | 2012-02-15 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Evidence that the beta subunit of Chlamydia trachomatis ribonucleotide reductase is active with the manganese ion of its manganese(IV)/iron(III) cofactor in site 1. J.Am.Chem.Soc., 134, 2012
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7KDX
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![BU of 7kdx by Molmil](/molmil-images/mine/7kdx) | Crystal structure of Streptomyces tokunonesis TokK with hydroxycobalamin, 5'-deoxyadenosine, and methionine | Descriptor: | 1,2-ETHANEDIOL, 5'-DEOXYADENOSINE, CHLORIDE ION, ... | Authors: | Knox, H.L, Booker, S.J, Boal, A.K. | Deposit date: | 2020-10-09 | Release date: | 2022-01-12 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (1.791 Å) | Cite: | Structure of a B 12 -dependent radical SAM enzyme in carbapenem biosynthesis. Nature, 602, 2022
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7KDY
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![BU of 7kdy by Molmil](/molmil-images/mine/7kdy) | Crystal structure of Streptomyces tokunonesis TokK with hydroxycobalamin, 5'-deoxyadenosine, methionine, and (2R)-pantetheinylated carbapenam | Descriptor: | (2R,3R,5R)-3-{[2-({N-[(2R)-2,4-dihydroxy-3,3-dimethylbutanoyl]-beta-alanyl}amino)ethyl]sulfanyl}-7-oxo-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 5'-DEOXYADENOSINE, COBALAMIN, ... | Authors: | Knox, H.L, Booker, S.J, Boal, A.K. | Deposit date: | 2020-10-09 | Release date: | 2022-01-12 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.939 Å) | Cite: | Structure of a B 12 -dependent radical SAM enzyme in carbapenem biosynthesis. Nature, 602, 2022
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7KPI
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![BU of 7kpi by Molmil](/molmil-images/mine/7kpi) | Crystal structure of the SPOP MATH domain | Descriptor: | Speckle-type POZ protein | Authors: | Usher, E.T, Boal, A.K. | Deposit date: | 2020-11-11 | Release date: | 2021-04-28 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Intrinsically disordered substrates dictate SPOP subnuclear localization and ubiquitination activity. J.Biol.Chem., 296, 2021
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7KPK
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6VP5
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![BU of 6vp5 by Molmil](/molmil-images/mine/6vp5) | Ethylene forming enzyme (EFE) D191E variant in complex with Fe(II), L-arginine, and 2OG | Descriptor: | 2-OXOGLUTARIC ACID, 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 2-oxoglutarate-dependent ethylene/succinate-forming enzyme, ... | Authors: | Davis, K.M, Copeland, R.A, Boal, A.K. | Deposit date: | 2020-02-01 | Release date: | 2021-02-03 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.97 Å) | Cite: | An Iron(IV)-Oxo Intermediate Initiating l-Arginine Oxidation but Not Ethylene Production by the 2-Oxoglutarate-Dependent Oxygenase, Ethylene-Forming Enzyme. J.Am.Chem.Soc., 143, 2021
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6VZY
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6VP4
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![BU of 6vp4 by Molmil](/molmil-images/mine/6vp4) | Ethylene forming enzyme (EFE) in complex with Fe(II), L-arginine, and 2OG | Descriptor: | 2-OXOGLUTARIC ACID, 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 2-oxoglutarate-dependent ethylene/succinate-forming enzyme, ... | Authors: | Davis, K.M, Copeland, R.A, Boal, A.K. | Deposit date: | 2020-02-01 | Release date: | 2021-02-03 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.83 Å) | Cite: | An Iron(IV)-Oxo Intermediate Initiating l-Arginine Oxidation but Not Ethylene Production by the 2-Oxoglutarate-Dependent Oxygenase, Ethylene-Forming Enzyme. J.Am.Chem.Soc., 143, 2021
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6DAX
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![BU of 6dax by Molmil](/molmil-images/mine/6dax) | X-ray crystal structure of VioC bound to Fe(II), L-homoarginine, and 2-oxoglutarate | Descriptor: | 2-OXOGLUTARIC ACID, Alpha-ketoglutarate-dependent L-arginine hydroxylase, FE (II) ION, ... | Authors: | Dunham, N.P, Mitchell, A.J, Boal, A.K. | Deposit date: | 2018-05-02 | Release date: | 2018-05-16 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Two Distinct Mechanisms for C-C Desaturation by Iron(II)- and 2-(Oxo)glutarate-Dependent Oxygenases: Importance of alpha-Heteroatom Assistance. J. Am. Chem. Soc., 140, 2018
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