7KDY

Crystal structure of Streptomyces tokunonesis TokK with hydroxycobalamin, 5'-deoxyadenosine, methionine, and (2R)-pantetheinylated carbapenam

Summary for 7KDY

• Entry DOI: 10.2210/pdb7kdy/pdb
• Descriptor: Methyltransferase TokK, IRON/SULFUR CLUSTER, COBALAMIN, ... (9 entities in total)
• Functional Keywords: radical sam, cobalamin, [4fe-4s] cluster, fes cluster, methyltransferase, b12, beta-lactam antibiotic synthesis, transferase
• Biological source: Streptomyces tokunonensis
• Total number of polymer chains: 2
• Total formula weight: 159854.23

Authors

Knox, H.L.,Booker, S.J.,Boal, A.K. (deposition date: 2020-10-09, release date: 2022-01-12, Last modification date: 2024-04-03)

• Primary citation: Knox, H.L.,Sinner, E.K.,Townsend, C.A.,Boal, A.K.,Booker, S.J.; Structure of a B 12 -dependent radical SAM enzyme in carbapenem biosynthesis.; Nature, 602:343-348, 2022; PubMed: 35110734; DOI: 10.1038/s41586-021-04392-4

Experimental method

X-RAY DIFFRACTION (1.939 Å)