5VNP

X-ray crystal structure of Halotag bound to the P1 benzoxadiazole fluorogenic ligand

Summary for 5VNP

• Entry DOI: 10.2210/pdb5vnp/pdb
• Descriptor: Haloalkane dehalogenase, N-{2-[2-(hexyloxy)ethoxy]ethyl}-N~2~-methyl-N~2~-{[7-(methylamino)-2,1,3-benzoxadiazol-4-yl]sulfonyl}glycinamide, CHLORIDE ION, ... (4 entities in total)
• Functional Keywords: biosensor, cytotoxicity, fluorescent probe, protein aggregation, proteome stress, hydrolase
• Biological source: Rhodococcus rhodochrous
• Total number of polymer chains: 2
• Total formula weight: 66867.36

Authors

Dunham, N.P.,Boal, A.K. (deposition date: 2017-05-01, release date: 2017-06-14, Last modification date: 2023-10-04)

• Primary citation: Liu, Y.,Fares, M.,Dunham, N.P.,Gao, Z.,Miao, K.,Jiang, X.,Bollinger, S.S.,Boal, A.K.,Zhang, X.; AgHalo: A Facile Fluorogenic Sensor to Detect Drug-Induced Proteome Stress.; Angew. Chem. Int. Ed. Engl., 56:8672-8676, 2017; PubMed: 28557281; DOI: 10.1002/anie.201702417

Experimental method

X-RAY DIFFRACTION (2.23 Å)