1I3X
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1i3x by Molmil](/molmil-images/mine/1i3x) | |
7UG7
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7ug7 by Molmil](/molmil-images/mine/7ug7) | 70S ribosome complex in an intermediate state of translocation bound to EF-G(GDP) stalled by Argyrin B | Descriptor: | 1,4-DIAMINOBUTANE, 16S rRNA, 23S rRNA, ... | Authors: | Rundlet, E.J, Wieland, M, Holm, M, Koller, T.O, Blanchard, S.C, Wilson, D.N. | Deposit date: | 2022-03-24 | Release date: | 2022-05-18 | Last modified: | 2024-07-10 | Method: | ELECTRON MICROSCOPY (2.58 Å) | Cite: | The cyclic octapeptide antibiotic argyrin B inhibits translation by trapping EF-G on the ribosome during translocation. Proc.Natl.Acad.Sci.USA, 119, 2022
|
|
5KCS
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5kcs by Molmil](/molmil-images/mine/5kcs) | Cryo-EM structure of the Escherichia coli 70S ribosome in complex with antibiotic Evernimycin, mRNA, TetM and P-site tRNA at 3.9A resolution | Descriptor: | (2R,3R,4R,6S)-6-{[(2R,3aR,4R,4'R,5'S,6S,6'R,7S,7aR)-6-{[(2S,3R,4R,5S,6R)-2-{[(2R,3S,4S,5S,6S)-6-({(2R,3aS,3a'R,6S,7R,7'R,7aS,7a'S)-7'-[(2,4-dihydroxy-6-methylbenzoyl)oxy]-7-hydroxyoctahydro-4H-2,4'-spirobi[[1,3]dioxolo[4,5-c]pyran]-6-yl}oxy)-4-hydroxy-5-methoxy-2-(methoxymethyl)tetrahydro-2H-pyran-3-yl]oxy}-3-hydroxy-5-methoxy-6-methyltetrahydro-2H-pyran-4-yl]oxy}-4',7-dihydroxy-4,6',7a-trimethyloctahydro-4H-spiro[1,3-dioxolo[4,5-c]pyran-2,2'-pyran]-5'-yl]oxy}-4-{[(2R,4S,5R,6S)-5-methoxy-4,6-dimethyl-4-nitrotetrahydro-2H-pyran-2-yl]oxy}-2-methyltetrahydro-2H-pyran-3-yl 3,5-dichloro-4-hydroxy-2-methoxy-6-methylbenzoate (non-preferred name), 16S Ribosomal RNA, 23S Ribosomal RNA, ... | Authors: | Arenz, S, Juette, M.F, Graf, M, Nguyen, F, Huter, P, Polikanov, Y.S, Blanchard, S.C, Wilson, D.N. | Deposit date: | 2016-06-06 | Release date: | 2016-08-17 | Last modified: | 2019-12-25 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | Structures of the orthosomycin antibiotics avilamycin and evernimicin in complex with the bacterial 70S ribosome. Proc.Natl.Acad.Sci.USA, 113, 2016
|
|
5KCR
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5kcr by Molmil](/molmil-images/mine/5kcr) | Cryo-EM structure of the Escherichia coli 70S ribosome in complex with antibiotic Avilamycin C, mRNA and P-site tRNA at 3.6A resolution | Descriptor: | (2R,3S,4R,6S)-4-hydroxy-6-{[(2R,3aR,4R,4'R,5'S,6S,6'R,7aR)-4'-hydroxy-6-{[(2S,3R,4R,5S,6R)-3-hydroxy-2-{[(2R,3S,4S,5S,6S)-4-hydroxy-6-({(2R,3aS,3a'R,6S,6'R,7R,7'R,7aR,7a'R)-7'-hydroxy-7'-[(1S)-1-hydroxyethyl]-6'-methyl-7-[(2-methylpropanoyl)oxy]octahydro-4H-2,4'-spirobi[[1,3]dioxolo[4,5-c]pyran]-6-yl}oxy)-5-methoxy-2-(methoxymethyl)tetrahydro-2H-pyran-3-yl]oxy}-5-methoxy-6-methyltetrahydro-2H-pyran-4-yl]oxy}-4,6',7a-trimethyloctahydro-4H-spiro[1,3-dioxolo[4,5-c]pyran-2,2'-pyran]-5'-yl]oxy}-2-methyltetrahydro-2H-pyran-3-yl 3,5-dichloro-4-hydroxy-2-methoxy-6-methylbenzoate (non-preferred name), 16S Ribosomal RNA, 23S Ribosomal RNA, ... | Authors: | Arenz, S, Juette, M.F, Graf, M, Nguyen, F, Huter, P, Polikanov, Y.S, Blanchard, S.C, Wilson, D.N. | Deposit date: | 2016-06-06 | Release date: | 2016-08-17 | Last modified: | 2019-12-25 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Structures of the orthosomycin antibiotics avilamycin and evernimicin in complex with the bacterial 70S ribosome. Proc.Natl.Acad.Sci.USA, 113, 2016
|
|
4V9D
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4v9d by Molmil](/molmil-images/mine/4v9d) | Structures of the bacterial ribosome in classical and hybrid states of tRNA binding | Descriptor: | 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ... | Authors: | Dunkle, J.A, Wang, L, Feldman, M.B, Pulk, A, Chen, V.B, Kapral, G.J, Noeske, J, Richardson, J.S, Blanchard, S.C, Cate, J.H.D. | Deposit date: | 2012-07-31 | Release date: | 2014-07-09 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Structures of the bacterial ribosome in classical and hybrid states of tRNA binding. Science, 332, 2011
|
|
8FZQ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8fzq by Molmil](/molmil-images/mine/8fzq) | Dehosphorylated, ATP-bound human cystic fibrosis transmembrane conductance regulator (CFTR) | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Cystic fibrosis transmembrane conductance regulator, MAGNESIUM ION | Authors: | Levring, J, Terry, D.S, Kilic, Z, Fitzgerald, G.A, Blanchard, S.C, Chen, J. | Deposit date: | 2023-01-29 | Release date: | 2023-03-29 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (4.3 Å) | Cite: | CFTR function, pathology and pharmacology at single-molecule resolution. Nature, 616, 2023
|
|
8G6J
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8g6j by Molmil](/molmil-images/mine/8g6j) | mRNA decoding in human is kinetically and structurally distinct from bacteria (GA state 2) | Descriptor: | (3R,6R,9S,12S,15S,18S,20R,24aR)-6-[(2S)-butan-2-yl]-3,12-bis[(1R)-1-hydroxy-2-methylpropyl]-8,9,11,17,18-pentamethyl-15-[(2S)-2-methylbutyl]hexadecahydropyrido[1,2-a][1,4,7,10,13,16,19]heptaazacyclohenicosine-1,4,7,10,13,16,19(21H)-heptone, (3beta)-O~3~-[(2R)-2,6-dihydroxy-2-(2-methoxy-2-oxoethyl)-6-methylheptanoyl]cephalotaxine, 1,4-DIAMINOBUTANE, ... | Authors: | Holm, M, Natchiar, K.S, Rundlet, E.J, Myasnikov, A.G, Altman, R.B, Blanchard, S.C. | Deposit date: | 2023-02-15 | Release date: | 2023-04-19 | Last modified: | 2023-11-15 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | mRNA decoding in human is kinetically and structurally distinct from bacteria. Nature, 617, 2023
|
|
8G5Y
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8g5y by Molmil](/molmil-images/mine/8g5y) | mRNA decoding in human is kinetically and structurally distinct from bacteria (IC state) | Descriptor: | 1,4-DIAMINOBUTANE, 18S rRNA, 28S rRNA, ... | Authors: | Holm, M, Natchiar, K.S, Rundlet, E.J, Myasnikov, A.G, Altman, R.B, Blanchard, S.C. | Deposit date: | 2023-02-14 | Release date: | 2023-04-19 | Last modified: | 2023-11-15 | Method: | ELECTRON MICROSCOPY (2.29 Å) | Cite: | mRNA decoding in human is kinetically and structurally distinct from bacteria. Nature, 617, 2023
|
|
8G60
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8g60 by Molmil](/molmil-images/mine/8g60) | mRNA decoding in human is kinetically and structurally distinct from bacteria (CR state) | Descriptor: | 1,4-DIAMINOBUTANE, 18S rRNA, 28S rRNA, ... | Authors: | Holm, M, Natchiar, K.S, Rundlet, E.J, Myasnikov, A.G, Altman, R.B, Blanchard, S.C. | Deposit date: | 2023-02-14 | Release date: | 2023-04-19 | Last modified: | 2023-11-15 | Method: | ELECTRON MICROSCOPY (2.54 Å) | Cite: | mRNA decoding in human is kinetically and structurally distinct from bacteria. Nature, 617, 2023
|
|
8G61
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8g61 by Molmil](/molmil-images/mine/8g61) | mRNA decoding in human is kinetically and structurally distinct from bacteria (AC state) | Descriptor: | 1,4-DIAMINOBUTANE, 18S rRNA, 28S rRNA, ... | Authors: | Holm, M, Natchiar, K.S, Rundlet, E.J, Myasnikov, A.G, Altman, R.B, Blanchard, S.C. | Deposit date: | 2023-02-14 | Release date: | 2023-04-19 | Last modified: | 2023-11-15 | Method: | ELECTRON MICROSCOPY (2.94 Å) | Cite: | mRNA decoding in human is kinetically and structurally distinct from bacteria. Nature, 617, 2023
|
|
8GLP
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8glp by Molmil](/molmil-images/mine/8glp) | mRNA decoding in human is kinetically and structurally distinct from bacteria (Consensus LSU focused refined structure) | Descriptor: | 1,4-DIAMINOBUTANE, 18S rRNA, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ... | Authors: | Holm, M, Natchiar, K.S, Rundlet, E.J, Myasnikov, A.G, Watson, Z.L, Altman, R.B, Blanchard, S.C. | Deposit date: | 2023-03-22 | Release date: | 2023-04-19 | Last modified: | 2023-11-15 | Method: | ELECTRON MICROSCOPY (1.67 Å) | Cite: | mRNA decoding in human is kinetically and structurally distinct from bacteria. Nature, 617, 2023
|
|
8G5Z
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8g5z by Molmil](/molmil-images/mine/8g5z) | mRNA decoding in human is kinetically and structurally distinct from bacteria (GA state) | Descriptor: | 1,4-DIAMINOBUTANE, 18S rRNA, 28S rRNA, ... | Authors: | Holm, M, Natchiar, K.S, Rundlet, E.J, Myasnikov, A.G, Altman, R.B, Blanchard, S.C. | Deposit date: | 2023-02-14 | Release date: | 2023-04-19 | Last modified: | 2023-11-15 | Method: | ELECTRON MICROSCOPY (2.64 Å) | Cite: | mRNA decoding in human is kinetically and structurally distinct from bacteria. Nature, 617, 2023
|
|
6GZ4
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6gz4 by Molmil](/molmil-images/mine/6gz4) | tRNA translocation by the eukaryotic 80S ribosome and the impact of GTP hydrolysis, Translocation-intermediate-POST-2 (TI-POST-2) | Descriptor: | 18S ribosomal RNA, 28S ribosomal RNA, 5.8S ribosomal RNA, ... | Authors: | Flis, J, Holm, M, Rundlet, E.J, Loerke, J, Hilal, T, Dabrowski, M, Buerger, J, Mielke, T, Blanchard, S.C, Spahn, C.M.T, Budkevich, T.V. | Deposit date: | 2018-07-03 | Release date: | 2018-12-05 | Last modified: | 2022-03-30 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | tRNA Translocation by the Eukaryotic 80S Ribosome and the Impact of GTP Hydrolysis. Cell Rep, 25, 2018
|
|
6GZ5
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6gz5 by Molmil](/molmil-images/mine/6gz5) | tRNA translocation by the eukaryotic 80S ribosome and the impact of GTP hydrolysis, Translocation-intermediate-POST-3 (TI-POST-3) | Descriptor: | 18S ribosomal RNA, 28S ribosomal RNA, 5.8S ribosomal RNA, ... | Authors: | Flis, J, Holm, M, Rundlet, E.J, Loerke, J, Hilal, T, Dabrowski, M, Buerger, J, Mielke, T, Blanchard, S.C, Spahn, C.M.T, Budkevich, T.V. | Deposit date: | 2018-07-03 | Release date: | 2018-12-05 | Last modified: | 2022-03-30 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | tRNA Translocation by the Eukaryotic 80S Ribosome and the Impact of GTP Hydrolysis. Cell Rep, 25, 2018
|
|
6GZ3
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6gz3 by Molmil](/molmil-images/mine/6gz3) | tRNA translocation by the eukaryotic 80S ribosome and the impact of GTP hydrolysis, Translocation-intermediate-POST-1 (TI-POST-1) | Descriptor: | 18S ribosomal RNA, 28S ribosomal RNA, 40S ribosomal protein S12, ... | Authors: | Flis, J, Holm, M, Rundlet, E.J, Loerke, J, Hilal, T, Dabrowski, M, Buerger, J, Mielke, T, Blanchard, S.C, Spahn, C.M.T, Budkevich, T.V. | Deposit date: | 2018-07-03 | Release date: | 2018-12-05 | Last modified: | 2022-03-30 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | tRNA Translocation by the Eukaryotic 80S Ribosome and the Impact of GTP Hydrolysis. Cell Rep, 25, 2018
|
|
7N31
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7n31 by Molmil](/molmil-images/mine/7n31) | Elongating 70S ribosome complex in a post-translocation (POST) conformation | Descriptor: | 1,4-DIAMINOBUTANE, 16S rRNA, 23S rRNA, ... | Authors: | Rundlet, E.J, Holm, M, Schacherl, M, Natchiar, K.S, Altman, R.B, Spahn, C.M.T, Myasnikov, A.G, Blanchard, S.C. | Deposit date: | 2021-05-31 | Release date: | 2021-07-14 | Last modified: | 2021-08-11 | Method: | ELECTRON MICROSCOPY (2.69 Å) | Cite: | Structural basis of early translocation events on the ribosome. Nature, 595, 2021
|
|
7N2U
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7n2u by Molmil](/molmil-images/mine/7n2u) | Elongating 70S ribosome complex in a hybrid-H1 pre-translocation (PRE-H1) conformation | Descriptor: | 1,4-DIAMINOBUTANE, 16S rRNA, 23S rRNA, ... | Authors: | Rundlet, E.J, Holm, M, Schacherl, M, Natchiar, K.S, Altman, R.B, Spahn, C.M.T, Myasnikov, A.G, Blanchard, S.C. | Deposit date: | 2021-05-29 | Release date: | 2021-07-14 | Last modified: | 2021-08-11 | Method: | ELECTRON MICROSCOPY (2.53 Å) | Cite: | Structural basis of early translocation events on the ribosome. Nature, 595, 2021
|
|
7N30
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7n30 by Molmil](/molmil-images/mine/7n30) | Elongating 70S ribosome complex in a hybrid-H2* pre-translocation (PRE-H2*) conformation | Descriptor: | 1,4-DIAMINOBUTANE, 16S rRNA, 23S rRNA, ... | Authors: | Rundlet, E.J, Holm, M, Schacherl, M, Natchiar, K.S, Altman, R.B, Spahn, C.M.T, Myasnikov, A.G, Blanchard, S.C. | Deposit date: | 2021-05-30 | Release date: | 2021-07-14 | Last modified: | 2021-08-11 | Method: | ELECTRON MICROSCOPY (2.66 Å) | Cite: | Structural basis of early translocation events on the ribosome. Nature, 595, 2021
|
|
7N1P
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7n1p by Molmil](/molmil-images/mine/7n1p) | Elongating 70S ribosome complex in a classical pre-translocation (PRE-C) conformation | Descriptor: | 1,4-DIAMINOBUTANE, 16S rRNA, 23S rRNA, ... | Authors: | Rundlet, E.J, Holm, M, Schacherl, M, Natchiar, S.K, Altman, R.B, Spahn, C.M.T, Myasnikov, A.G, Blanchard, S.C. | Deposit date: | 2021-05-28 | Release date: | 2021-07-14 | Last modified: | 2021-08-11 | Method: | ELECTRON MICROSCOPY (2.33 Å) | Cite: | Structural basis of early translocation events on the ribosome. Nature, 595, 2021
|
|
7N2V
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7n2v by Molmil](/molmil-images/mine/7n2v) | Elongating 70S ribosome complex in a spectinomycin-stalled intermediate state of translocation bound to EF-G in an active, GTP conformation (INT1) | Descriptor: | 1,4-DIAMINOBUTANE, 16S rRNA, 23S rRNA, ... | Authors: | Rundlet, E.J, Holm, M, Schacherl, M, Natchiar, K.S, Altman, R.B, Spahn, C.M.T, Myasnikov, A.G, Blanchard, S.C. | Deposit date: | 2021-05-29 | Release date: | 2021-07-14 | Last modified: | 2021-08-11 | Method: | ELECTRON MICROSCOPY (2.54 Å) | Cite: | Structural basis of early translocation events on the ribosome. Nature, 595, 2021
|
|
7N2C
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7n2c by Molmil](/molmil-images/mine/7n2c) | Elongating 70S ribosome complex in a fusidic acid-stalled intermediate state of translocation bound to EF-G(GDP) (INT2) | Descriptor: | 1,4-DIAMINOBUTANE, 16S rRNA, 23S rRNA, ... | Authors: | Rundlet, E.J, Holm, M, Schacherl, M, Natchiar, K.S, Altman, R.B, Spahn, C.M.T, Myasnikov, A.G, Blanchard, S.C. | Deposit date: | 2021-05-28 | Release date: | 2021-07-14 | Last modified: | 2021-08-11 | Method: | ELECTRON MICROSCOPY (2.72 Å) | Cite: | Structural basis of early translocation events on the ribosome. Nature, 595, 2021
|
|
1I3Y
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1i3y by Molmil](/molmil-images/mine/1i3y) | |
4Z3S
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4z3s by Molmil](/molmil-images/mine/4z3s) | Crystal structure of the Thermus thermophilus 70S ribosome in complex with antibiotic A201A, mRNA and three tRNAs in the A, P and E sites at 2.65A resolution | Descriptor: | 16S Ribosomal RNA, 23S Ribosomal RNA, 3'-deoxy-3'-{[(2E)-3-(4-{[(4Z)-6-O-(6-deoxy-3,4-di-O-methyl-alpha-D-mannopyranosyl)-5-O-methyl-alpha-D-threo-hex-4-enofuranosyl]oxy}phenyl)-2-methylprop-2-enoyl]amino}-N,N-dimethyladenosine, ... | Authors: | Polikanov, Y.S, Starosta, A.L, Juette, M.F, Altman, R.B, Terry, D.S, Lu, W, Burnett, B.J, Dinos, G, Reynolds, K, Blanchard, S.C, Steitz, T.A, Wilson, D.N. | Deposit date: | 2015-03-31 | Release date: | 2015-06-03 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.65 Å) | Cite: | Distinct tRNA Accommodation Intermediates Observed on the Ribosome with the Antibiotics Hygromycin A and A201A. Mol.Cell, 58, 2015
|
|
4WF1
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4wf1 by Molmil](/molmil-images/mine/4wf1) | Crystal structure of the E. coli ribosome bound to negamycin. | Descriptor: | 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ... | Authors: | Olivier, N.B, Altman, R.B, Noeske, J, Basarab, G.S, Code, E, Ferguson, A.D, Gao, N, Huang, J, Juette, M.F, Livchak, S, Miller, M.D, Prince, D.B, Cate, J.H.D, Buurman, E.T, Blanchard, S.C. | Deposit date: | 2014-09-11 | Release date: | 2014-11-05 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (3.09 Å) | Cite: | Negamycin induces translational stalling and miscoding by binding to the small subunit head domain of the Escherichia coli ribosome. Proc.Natl.Acad.Sci.USA, 111, 2014
|
|
4V9C
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4v9c by Molmil](/molmil-images/mine/4v9c) | Allosteric control of the ribosome by small-molecule antibiotics | Descriptor: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | Authors: | Cate, J.H.D, Pulk, A, Blanchard, S.C, Wang, L, Feldman, M.B, Wasserman, M.R, Altman, R. | Deposit date: | 2012-07-25 | Release date: | 2014-07-09 | Last modified: | 2014-12-10 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | Allosteric control of the ribosome by small-molecule antibiotics. Nat.Struct.Mol.Biol., 19, 2012
|
|