1I3X
 
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7UG7
 | | 70S ribosome complex in an intermediate state of translocation bound to EF-G(GDP) stalled by Argyrin B | | 分子名称: | 1,4-DIAMINOBUTANE, 16S rRNA, 23S rRNA, ... | | 著者 | Rundlet, E.J, Wieland, M, Holm, M, Koller, T.O, Blanchard, S.C, Wilson, D.N. | | 登録日 | 2022-03-24 | | 公開日 | 2022-05-18 | | 最終更新日 | 2024-07-10 | | 実験手法 | ELECTRON MICROSCOPY (2.58 Å) | | 主引用文献 | The cyclic octapeptide antibiotic argyrin B inhibits translation by trapping EF-G on the ribosome during translocation.
Proc.Natl.Acad.Sci.USA, 119, 2022
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4V9D
 | | Structures of the bacterial ribosome in classical and hybrid states of tRNA binding | | 分子名称: | 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ... | | 著者 | Dunkle, J.A, Wang, L, Feldman, M.B, Pulk, A, Chen, V.B, Kapral, G.J, Noeske, J, Richardson, J.S, Blanchard, S.C, Cate, J.H.D. | | 登録日 | 2012-07-31 | | 公開日 | 2014-07-09 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Structures of the bacterial ribosome in classical and hybrid states of tRNA binding.
Science, 332, 2011
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5KCS
 | | Cryo-EM structure of the Escherichia coli 70S ribosome in complex with antibiotic Evernimycin, mRNA, TetM and P-site tRNA at 3.9A resolution | | 分子名称: | (2R,3R,4R,6S)-6-{[(2R,3aR,4R,4'R,5'S,6S,6'R,7S,7aR)-6-{[(2S,3R,4R,5S,6R)-2-{[(2R,3S,4S,5S,6S)-6-({(2R,3aS,3a'R,6S,7R,7'R,7aS,7a'S)-7'-[(2,4-dihydroxy-6-methylbenzoyl)oxy]-7-hydroxyoctahydro-4H-2,4'-spirobi[[1,3]dioxolo[4,5-c]pyran]-6-yl}oxy)-4-hydroxy-5-methoxy-2-(methoxymethyl)tetrahydro-2H-pyran-3-yl]oxy}-3-hydroxy-5-methoxy-6-methyltetrahydro-2H-pyran-4-yl]oxy}-4',7-dihydroxy-4,6',7a-trimethyloctahydro-4H-spiro[1,3-dioxolo[4,5-c]pyran-2,2'-pyran]-5'-yl]oxy}-4-{[(2R,4S,5R,6S)-5-methoxy-4,6-dimethyl-4-nitrotetrahydro-2H-pyran-2-yl]oxy}-2-methyltetrahydro-2H-pyran-3-yl 3,5-dichloro-4-hydroxy-2-methoxy-6-methylbenzoate (non-preferred name), 16S Ribosomal RNA, 23S Ribosomal RNA, ... | | 著者 | Arenz, S, Juette, M.F, Graf, M, Nguyen, F, Huter, P, Polikanov, Y.S, Blanchard, S.C, Wilson, D.N. | | 登録日 | 2016-06-06 | | 公開日 | 2016-08-17 | | 最終更新日 | 2019-12-25 | | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | | 主引用文献 | Structures of the orthosomycin antibiotics avilamycin and evernimicin in complex with the bacterial 70S ribosome.
Proc.Natl.Acad.Sci.USA, 113, 2016
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5KCR
 | | Cryo-EM structure of the Escherichia coli 70S ribosome in complex with antibiotic Avilamycin C, mRNA and P-site tRNA at 3.6A resolution | | 分子名称: | (2R,3S,4R,6S)-4-hydroxy-6-{[(2R,3aR,4R,4'R,5'S,6S,6'R,7aR)-4'-hydroxy-6-{[(2S,3R,4R,5S,6R)-3-hydroxy-2-{[(2R,3S,4S,5S,6S)-4-hydroxy-6-({(2R,3aS,3a'R,6S,6'R,7R,7'R,7aR,7a'R)-7'-hydroxy-7'-[(1S)-1-hydroxyethyl]-6'-methyl-7-[(2-methylpropanoyl)oxy]octahydro-4H-2,4'-spirobi[[1,3]dioxolo[4,5-c]pyran]-6-yl}oxy)-5-methoxy-2-(methoxymethyl)tetrahydro-2H-pyran-3-yl]oxy}-5-methoxy-6-methyltetrahydro-2H-pyran-4-yl]oxy}-4,6',7a-trimethyloctahydro-4H-spiro[1,3-dioxolo[4,5-c]pyran-2,2'-pyran]-5'-yl]oxy}-2-methyltetrahydro-2H-pyran-3-yl 3,5-dichloro-4-hydroxy-2-methoxy-6-methylbenzoate (non-preferred name), 16S Ribosomal RNA, 23S Ribosomal RNA, ... | | 著者 | Arenz, S, Juette, M.F, Graf, M, Nguyen, F, Huter, P, Polikanov, Y.S, Blanchard, S.C, Wilson, D.N. | | 登録日 | 2016-06-06 | | 公開日 | 2016-08-17 | | 最終更新日 | 2019-12-25 | | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | | 主引用文献 | Structures of the orthosomycin antibiotics avilamycin and evernimicin in complex with the bacterial 70S ribosome.
Proc.Natl.Acad.Sci.USA, 113, 2016
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8G6J
 | | mRNA decoding in human is kinetically and structurally distinct from bacteria (GA state 2) | | 分子名称: | (3R,6R,9S,12S,15S,18S,20R,24aR)-6-[(2S)-butan-2-yl]-3,12-bis[(1R)-1-hydroxy-2-methylpropyl]-8,9,11,17,18-pentamethyl-15-[(2S)-2-methylbutyl]hexadecahydropyrido[1,2-a][1,4,7,10,13,16,19]heptaazacyclohenicosine-1,4,7,10,13,16,19(21H)-heptone, (3beta)-O~3~-[(2R)-2,6-dihydroxy-2-(2-methoxy-2-oxoethyl)-6-methylheptanoyl]cephalotaxine, 1,4-DIAMINOBUTANE, ... | | 著者 | Holm, M, Natchiar, K.S, Rundlet, E.J, Myasnikov, A.G, Altman, R.B, Blanchard, S.C. | | 登録日 | 2023-02-15 | | 公開日 | 2023-04-19 | | 最終更新日 | 2023-11-15 | | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | | 主引用文献 | mRNA decoding in human is kinetically and structurally distinct from bacteria.
Nature, 617, 2023
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8G60
 | | mRNA decoding in human is kinetically and structurally distinct from bacteria (CR state) | | 分子名称: | 1,4-DIAMINOBUTANE, 18S rRNA, 28S rRNA, ... | | 著者 | Holm, M, Natchiar, K.S, Rundlet, E.J, Myasnikov, A.G, Altman, R.B, Blanchard, S.C. | | 登録日 | 2023-02-14 | | 公開日 | 2023-04-19 | | 最終更新日 | 2023-11-15 | | 実験手法 | ELECTRON MICROSCOPY (2.54 Å) | | 主引用文献 | mRNA decoding in human is kinetically and structurally distinct from bacteria.
Nature, 617, 2023
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8G5Z
 | | mRNA decoding in human is kinetically and structurally distinct from bacteria (GA state) | | 分子名称: | 1,4-DIAMINOBUTANE, 18S rRNA, 28S rRNA, ... | | 著者 | Holm, M, Natchiar, K.S, Rundlet, E.J, Myasnikov, A.G, Altman, R.B, Blanchard, S.C. | | 登録日 | 2023-02-14 | | 公開日 | 2023-04-19 | | 最終更新日 | 2023-11-15 | | 実験手法 | ELECTRON MICROSCOPY (2.64 Å) | | 主引用文献 | mRNA decoding in human is kinetically and structurally distinct from bacteria.
Nature, 617, 2023
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8FZQ
 | | Dehosphorylated, ATP-bound human cystic fibrosis transmembrane conductance regulator (CFTR) | | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, Cystic fibrosis transmembrane conductance regulator, MAGNESIUM ION | | 著者 | Levring, J, Terry, D.S, Kilic, Z, Fitzgerald, G.A, Blanchard, S.C, Chen, J. | | 登録日 | 2023-01-29 | | 公開日 | 2023-03-29 | | 最終更新日 | 2024-06-19 | | 実験手法 | ELECTRON MICROSCOPY (4.3 Å) | | 主引用文献 | CFTR function, pathology and pharmacology at single-molecule resolution.
Nature, 616, 2023
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8G5Y
 | | mRNA decoding in human is kinetically and structurally distinct from bacteria (IC state) | | 分子名称: | 1,4-DIAMINOBUTANE, 18S rRNA, 28S rRNA, ... | | 著者 | Holm, M, Natchiar, K.S, Rundlet, E.J, Myasnikov, A.G, Altman, R.B, Blanchard, S.C. | | 登録日 | 2023-02-14 | | 公開日 | 2023-04-19 | | 最終更新日 | 2023-11-15 | | 実験手法 | ELECTRON MICROSCOPY (2.29 Å) | | 主引用文献 | mRNA decoding in human is kinetically and structurally distinct from bacteria.
Nature, 617, 2023
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8G61
 | | mRNA decoding in human is kinetically and structurally distinct from bacteria (AC state) | | 分子名称: | 1,4-DIAMINOBUTANE, 18S rRNA, 28S rRNA, ... | | 著者 | Holm, M, Natchiar, K.S, Rundlet, E.J, Myasnikov, A.G, Altman, R.B, Blanchard, S.C. | | 登録日 | 2023-02-14 | | 公開日 | 2023-04-19 | | 最終更新日 | 2023-11-15 | | 実験手法 | ELECTRON MICROSCOPY (2.94 Å) | | 主引用文献 | mRNA decoding in human is kinetically and structurally distinct from bacteria.
Nature, 617, 2023
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8GLP
 | | mRNA decoding in human is kinetically and structurally distinct from bacteria (Consensus LSU focused refined structure) | | 分子名称: | 1,4-DIAMINOBUTANE, 18S rRNA, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ... | | 著者 | Holm, M, Natchiar, K.S, Rundlet, E.J, Myasnikov, A.G, Watson, Z.L, Altman, R.B, Blanchard, S.C. | | 登録日 | 2023-03-22 | | 公開日 | 2023-04-19 | | 最終更新日 | 2023-11-15 | | 実験手法 | ELECTRON MICROSCOPY (1.67 Å) | | 主引用文献 | mRNA decoding in human is kinetically and structurally distinct from bacteria.
Nature, 617, 2023
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4WOI
 | | 4,5-linked aminoglycoside antibiotics regulate the bacterial ribosome by targeting dynamic conformational processes within intersubunit bridge B2 | | 分子名称: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | | 著者 | Pulk, A, Cate, J.H.D, Blanchard, S, Wasserman, M, Altman, R, Zhou, Z, Zinder, J, Green, K, Garneau-Tsodikova, S. | | 登録日 | 2014-10-15 | | 公開日 | 2015-08-05 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Chemically related 4,5-linked aminoglycoside antibiotics drive subunit rotation in opposite directions.
Nat Commun, 6, 2015
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7N31
 | | Elongating 70S ribosome complex in a post-translocation (POST) conformation | | 分子名称: | 1,4-DIAMINOBUTANE, 16S rRNA, 23S rRNA, ... | | 著者 | Rundlet, E.J, Holm, M, Schacherl, M, Natchiar, K.S, Altman, R.B, Spahn, C.M.T, Myasnikov, A.G, Blanchard, S.C. | | 登録日 | 2021-05-31 | | 公開日 | 2021-07-14 | | 最終更新日 | 2021-08-11 | | 実験手法 | ELECTRON MICROSCOPY (2.69 Å) | | 主引用文献 | Structural basis of early translocation events on the ribosome.
Nature, 595, 2021
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7N2U
 | | Elongating 70S ribosome complex in a hybrid-H1 pre-translocation (PRE-H1) conformation | | 分子名称: | 1,4-DIAMINOBUTANE, 16S rRNA, 23S rRNA, ... | | 著者 | Rundlet, E.J, Holm, M, Schacherl, M, Natchiar, K.S, Altman, R.B, Spahn, C.M.T, Myasnikov, A.G, Blanchard, S.C. | | 登録日 | 2021-05-29 | | 公開日 | 2021-07-14 | | 最終更新日 | 2021-08-11 | | 実験手法 | ELECTRON MICROSCOPY (2.53 Å) | | 主引用文献 | Structural basis of early translocation events on the ribosome.
Nature, 595, 2021
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7N30
 | | Elongating 70S ribosome complex in a hybrid-H2* pre-translocation (PRE-H2*) conformation | | 分子名称: | 1,4-DIAMINOBUTANE, 16S rRNA, 23S rRNA, ... | | 著者 | Rundlet, E.J, Holm, M, Schacherl, M, Natchiar, K.S, Altman, R.B, Spahn, C.M.T, Myasnikov, A.G, Blanchard, S.C. | | 登録日 | 2021-05-30 | | 公開日 | 2021-07-14 | | 最終更新日 | 2021-08-11 | | 実験手法 | ELECTRON MICROSCOPY (2.66 Å) | | 主引用文献 | Structural basis of early translocation events on the ribosome.
Nature, 595, 2021
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7N1P
 | | Elongating 70S ribosome complex in a classical pre-translocation (PRE-C) conformation | | 分子名称: | 1,4-DIAMINOBUTANE, 16S rRNA, 23S rRNA, ... | | 著者 | Rundlet, E.J, Holm, M, Schacherl, M, Natchiar, S.K, Altman, R.B, Spahn, C.M.T, Myasnikov, A.G, Blanchard, S.C. | | 登録日 | 2021-05-28 | | 公開日 | 2021-07-14 | | 最終更新日 | 2021-08-11 | | 実験手法 | ELECTRON MICROSCOPY (2.33 Å) | | 主引用文献 | Structural basis of early translocation events on the ribosome.
Nature, 595, 2021
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7N2V
 | | Elongating 70S ribosome complex in a spectinomycin-stalled intermediate state of translocation bound to EF-G in an active, GTP conformation (INT1) | | 分子名称: | 1,4-DIAMINOBUTANE, 16S rRNA, 23S rRNA, ... | | 著者 | Rundlet, E.J, Holm, M, Schacherl, M, Natchiar, K.S, Altman, R.B, Spahn, C.M.T, Myasnikov, A.G, Blanchard, S.C. | | 登録日 | 2021-05-29 | | 公開日 | 2021-07-14 | | 最終更新日 | 2021-08-11 | | 実験手法 | ELECTRON MICROSCOPY (2.54 Å) | | 主引用文献 | Structural basis of early translocation events on the ribosome.
Nature, 595, 2021
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7N2C
 | | Elongating 70S ribosome complex in a fusidic acid-stalled intermediate state of translocation bound to EF-G(GDP) (INT2) | | 分子名称: | 1,4-DIAMINOBUTANE, 16S rRNA, 23S rRNA, ... | | 著者 | Rundlet, E.J, Holm, M, Schacherl, M, Natchiar, K.S, Altman, R.B, Spahn, C.M.T, Myasnikov, A.G, Blanchard, S.C. | | 登録日 | 2021-05-28 | | 公開日 | 2021-07-14 | | 最終更新日 | 2021-08-11 | | 実験手法 | ELECTRON MICROSCOPY (2.72 Å) | | 主引用文献 | Structural basis of early translocation events on the ribosome.
Nature, 595, 2021
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3J0L
 | | Core of mammalian 80S pre-ribosome in complex with tRNAs fitted to a 9.8A cryo-EM map: classic PRE state 1 | | 分子名称: | 40S ribosomal RNA fragment, 60S ribosomal RNA fragment, Ribosomal protein L10, ... | | 著者 | Budkevich, T, Giesebrecht, J, Altman, R, Munro, J, Mielke, T, Nierhaus, K, Blanchard, S, Spahn, C.M. | | 登録日 | 2011-10-04 | | 公開日 | 2011-11-16 | | 最終更新日 | 2024-02-21 | | 実験手法 | ELECTRON MICROSCOPY (9.8 Å) | | 主引用文献 | Structure and dynamics of the Mammalian ribosomal pretranslocation complex.
Mol.Cell, 44, 2011
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4WF1
 | | Crystal structure of the E. coli ribosome bound to negamycin. | | 分子名称: | 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ... | | 著者 | Olivier, N.B, Altman, R.B, Noeske, J, Basarab, G.S, Code, E, Ferguson, A.D, Gao, N, Huang, J, Juette, M.F, Livchak, S, Miller, M.D, Prince, D.B, Cate, J.H.D, Buurman, E.T, Blanchard, S.C. | | 登録日 | 2014-09-11 | | 公開日 | 2014-11-05 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (3.09 Å) | | 主引用文献 | Negamycin induces translational stalling and miscoding by binding to the small subunit head domain of the Escherichia coli ribosome.
Proc.Natl.Acad.Sci.USA, 111, 2014
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4Z3S
 | | Crystal structure of the Thermus thermophilus 70S ribosome in complex with antibiotic A201A, mRNA and three tRNAs in the A, P and E sites at 2.65A resolution | | 分子名称: | 16S Ribosomal RNA, 23S Ribosomal RNA, 3'-deoxy-3'-{[(2E)-3-(4-{[(4Z)-6-O-(6-deoxy-3,4-di-O-methyl-alpha-D-mannopyranosyl)-5-O-methyl-alpha-D-threo-hex-4-enofuranosyl]oxy}phenyl)-2-methylprop-2-enoyl]amino}-N,N-dimethyladenosine, ... | | 著者 | Polikanov, Y.S, Starosta, A.L, Juette, M.F, Altman, R.B, Terry, D.S, Lu, W, Burnett, B.J, Dinos, G, Reynolds, K, Blanchard, S.C, Steitz, T.A, Wilson, D.N. | | 登録日 | 2015-03-31 | | 公開日 | 2015-06-03 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | | 主引用文献 | Distinct tRNA Accommodation Intermediates Observed on the Ribosome with the Antibiotics Hygromycin A and A201A.
Mol.Cell, 58, 2015
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3J0O
 | | Core of mammalian 80S pre-ribosome in complex with tRNAs fitted to a 9A cryo-EM map: classic PRE state 2 | | 分子名称: | 40S ribosomal RNA fragment, 60S ribosomal RNA fragment, Ribosomal protein L10a, ... | | 著者 | Budkevich, T, Giesebrecht, J, Altman, R, Munro, J, Mielke, T, Nierhaus, K, Blanchard, S, Spahn, C.M. | | 登録日 | 2011-10-05 | | 公開日 | 2011-11-16 | | 最終更新日 | 2024-02-21 | | 実験手法 | ELECTRON MICROSCOPY (9 Å) | | 主引用文献 | Structure and dynamics of the Mammalian ribosomal pretranslocation complex.
Mol.Cell, 44, 2011
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3J0Q
 | | Core of mammalian 80S pre-ribosome in complex with tRNAs fitted to a 10.6A cryo-em map: rotated PRE state 2 | | 分子名称: | 40S ribosomal RNA fragment, 60S ribosomal RNA fragment, Ribosomal protein L10, ... | | 著者 | Budkevich, T, Giesebrecht, J, Altman, R, Munro, J, Mielke, T, Nierhaus, K, Blanchard, S, Spahn, C.M. | | 登録日 | 2011-10-11 | | 公開日 | 2011-11-16 | | 最終更新日 | 2024-02-21 | | 実験手法 | ELECTRON MICROSCOPY (10.6 Å) | | 主引用文献 | Structure and dynamics of the Mammalian ribosomal pretranslocation complex.
Mol.Cell, 44, 2011
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3J0P
 | | Core of mammalian 80S pre-ribosome in complex with tRNAs fitted to a 10.6A cryo-em map: rotated PRE state 1 | | 分子名称: | 40S ribosomal RNA fragment, 60S ribosomal RNA fragment, Ribosomal protein L10a, ... | | 著者 | Budkevich, T, Giesebrecht, J, Altman, R, Munro, J, Mielke, T, Nierhaus, K, Blanchard, S, Spahn, C.M. | | 登録日 | 2011-10-06 | | 公開日 | 2011-11-16 | | 最終更新日 | 2024-02-21 | | 実験手法 | ELECTRON MICROSCOPY (10.6 Å) | | 主引用文献 | Structure and dynamics of the Mammalian ribosomal pretranslocation complex.
Mol.Cell, 44, 2011
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