4WOI

4,5-linked aminoglycoside antibiotics regulate the bacterial ribosome by targeting dynamic conformational processes within intersubunit bridge B2

This is a non-PDB format compatible entry.

Summary for 4WOI

• Entry DOI: 10.2210/pdb4woi/pdb
• Related: 4GAQ 4GAR 4GAS 4GAU
• Descriptor: 16S ribosomal RNA, 30S ribosomal protein S10, 30S ribosomal protein S11, ... (60 entities in total)
• Functional Keywords: protein biosynthesis, ribosomes, paromomycin, antibiotic translocation, rna, trna, transfer, exit, peptidyl, 30s, 70s, 16s, ribosomal subunit, ribosome
• Biological source: Escherichia coli str. K-12 substr. MDS42; More
• Total number of polymer chains: 110
• Total formula weight: 4419077.67

Authors

Pulk, A.,Cate, J.H.D.,Blanchard, S.,Wasserman, M.,Altman, R.,Zhou, Z.,Zinder, J.,Green, K.,Garneau-Tsodikova, S. (deposition date: 2014-10-15, release date: 2015-08-05, Last modification date: 2023-12-27)

• Primary citation: Wasserman, M.R.,Pulk, A.,Zhou, Z.,Altman, R.B.,Zinder, J.C.,Green, K.D.,Garneau-Tsodikova, S.,Doudna Cate, J.H.,Blanchard, S.C.; Chemically related 4,5-linked aminoglycoside antibiotics drive subunit rotation in opposite directions.; Nat Commun, 6:7896-7896, 2015; PubMed: 26224058; DOI: 10.1038/ncomms8896

Experimental method

X-RAY DIFFRACTION (3 Å)