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PDB: 141 件
1S7K
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RimL- Ribosomal L7/L12 alpha-N-protein acetyltransferase crystal form 2 (apo)
分子名称: acetyl transferase
著者Vetting, M.W, de Carvalho, L.P, Roderick, S.L, Blanchard, J.S.
登録日2004-01-29
公開日2005-03-15
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献A novel dimeric structure of the RimL Nalpha-acetyltransferase from Salmonella typhimurium.
J.Biol.Chem., 280, 2005
1KGQ
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Crystal Structure of Tetrahydrodipicolinate N-Succinyltransferase in Complex with L-2-aminopimelate and Succinamide-CoA
分子名称: (2S)-2-aminoheptanedioic acid, 2,3,4,5-TETRAHYDROPYRIDINE-2-CARBOXYLATE N-SUCCINYLTRANSFERASE, SUCCINAMIDE-COA
著者Beaman, T.W, Vogel, K.W, Drueckhammer, D.G, Blanchard, J.S, Roderick, S.L.
登録日2001-11-28
公開日2002-04-03
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Acyl group specificity at the active site of tetrahydridipicolinate N-succinyltransferase.
Protein Sci., 11, 2002
1KGT
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Crystal Structure of Tetrahydrodipicolinate N-Succinyltransferase in Complex with Pimelate and Succinyl-CoA
分子名称: 2,3,4,5-TETRAHYDROPYRIDINE-2-CARBOXYLATE N-SUCCINYLTRANSFERASE, PIMELIC ACID, SUCCINYL-COENZYME A
著者Beaman, T.W, Vogel, K.W, Drueckhammer, D.G, Blanchard, J.S, Roderick, S.L.
登録日2001-11-28
公開日2002-04-03
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Acyl group specificity at the active site of tetrahydridipicolinate N-succinyltransferase.
Protein Sci., 11, 2002
2XT2
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Structure of the pentapeptide repeat protein AlbG, a resistance factor for the topoisomerase poison albicidin.
分子名称: MCBG-LIKE PROTEIN, SULFATE ION
著者Vetting, M.W, Hegde, S.S, Blanchard, J.S.
登録日2010-10-05
公開日2010-10-13
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (1.999 Å)
主引用文献Pentapeptide-Repeat Proteins that Act as Topoisomerase Poison Resistance Factors Have a Common Dimer Interface.
Acta Crystallogr.,Sect.F, 67, 2011
4M0D
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Crystal structure of MurQ from H.influenzae in apo form
分子名称: N-acetylmuramic acid 6-phosphate etherase
著者Hazra, S, Blanchard, J.
登録日2013-08-01
公開日2014-02-26
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.577 Å)
主引用文献Structure of MurNAc 6-phosphate hydrolase (MurQ) from Haemophilus influenzae with a bound inhibitor.
Biochemistry, 52, 2013
4JLF
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Inhibitor resistant (R220A) substitution in the Mycobacterium tuberculosis beta-lactamase
分子名称: Beta-lactamase, PHOSPHATE ION
著者Hazra, S, Kurz, S, Blanchard, J, Bonomo, R.
登録日2013-03-12
公開日2013-10-30
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Can inhibitor-resistant substitutions in the Mycobacterium tuberculosis beta-Lactamase BlaC lead to clavulanate resistance?: a biochemical rationale for the use of beta-lactam-beta-lactamase inhibitor combinations.
Antimicrob.Agents Chemother., 57, 2013
2XT4
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Structure of the pentapeptide repeat protein AlbG, a resistance factor for the topoisomerase poison albicidin.
分子名称: MCBG-LIKE PROTEIN
著者Vetting, M.W, Hegde, S.S, Blanchard, J.S.
登録日2010-10-05
公開日2010-10-13
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.394 Å)
主引用文献Pentapeptide-Repeat Proteins that Act as Topoisomerase Poison Resistance Factors Have a Common Dimer Interface.
Acta Crystallogr.,Sect.F, 67, 2011
2VBQ
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Structure of AAC(6')-Iy in complex with bisubstrate analog CoA-S- monomethyl-acetylneamine.
分子名称: (3R,9Z)-17-[(2R,3S,4R,5R,6R)-5-amino-6-{[(1R,2R,3S,4R,6S)-4,6-diamino-2,3-dihydroxycyclohexyl]oxy}-3,4-dihydroxytetrahydro-2H-pyran-2-yl]-3-hydroxy-2,2-dimethyl-4,8,15-trioxo-12-thia-5,9,16-triazaheptadec-9-en-1-yl [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]methyl dihydrogen diphosphate, AMINOGLYCOSIDE 6'-N-ACETYLTRANSFERASE, GLYCEROL, ...
著者Vetting, M.W, Magalhaes, M.L, Freiburger, L, Gao, F, Auclair, K, Blanchard, J.S.
登録日2007-09-14
公開日2008-01-08
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Kinetic and Structural Analysis of Bisubstrate Inhibition of the Salmonella Enterica Aminoglycoside 6'-N-Acetyltransferase.
Biochemistry, 47, 2008
3N8S
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Crystal Structure of BlaC-E166A covalently bound with Cefamandole
分子名称: (2R)-2-[(1R)-1-{[(2R)-2-hydroxy-2-phenylacetyl]amino}-2-oxoethyl]-5-{[(1-methyl-1H-tetrazol-5-yl)sulfanyl]methyl}-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid, Beta-lactamase, PHOSPHATE ION
著者Tremblay, L.W, Blanchard, J.S.
登録日2010-05-28
公開日2010-11-24
最終更新日2017-11-08
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structures of the Michaelis Complex (1.2 A) and the Covalent Acyl Intermediate (2.0 A) of Cefamandole Bound in the Active Sites of the Mycobacterium tuberculosis beta-Lactamase K73A and E166A Mutants.
Biochemistry, 49, 2010
3N6I
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Crystal Structure of BlaC-E166A covalently bound with 6-aminopenicillian
分子名称: (2R,4S)-2-[(1R)-1-amino-2-oxoethyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid, Beta-lactamase, PHOSPHATE ION
著者Tremblay, L.W, Blanchard, J.S.
登録日2010-05-25
公開日2011-12-14
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献The Structure Activity Relationship of BlaC with all classes of beta-lactams
To be Published
3M6B
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Crystal Structure of the Ertapenem Pre-isomerized Covalent Adduct with TB B-lactamase
分子名称: (4R,5S)-3-({(3S,5S)-5-[(3-carboxyphenyl)carbamoyl]pyrrolidin-3-yl}sulfanyl)-5-[(1S,2R)-1-formyl-2-hydroxypropyl]-4-methyl-4,5-dihydro-1H-pyrrole-2-carboxylic acid, Beta-lactamase, PHOSPHATE ION
著者Tremblay, L.W, Fan, F, Blanchard, J.S.
登録日2010-03-15
公開日2010-04-14
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.3 Å)
主引用文献Biochemical and structural characterization of Mycobacterium tuberculosis beta-lactamase with the carbapenems ertapenem and doripenem.
Biochemistry, 49, 2010
3NDE
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Crystal Structure of BlaC-E166A covalently bound with Cephalotin
分子名称: (2R)-5-[(acetyloxy)methyl]-2-{(1R)-2-oxo-1-[(thiophen-2-ylacetyl)amino]ethyl}-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid, Beta-lactamase, PHOSPHATE ION
著者Tremblay, L.W, Blanchard, J.S.
登録日2010-06-07
公開日2011-12-14
最終更新日2017-11-08
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献BlaC-E166A covalently bound with cephalosporins and penicillins
To be Published
3NCK
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Crystal Structure of BlaC-E166A covalently bound with Nafcillin
分子名称: (2R,4S)-2-[(1R)-1-{[(2-ethoxynaphthalen-1-yl)carbonyl]amino}-2-oxoethyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid, Beta-lactamase
著者Tremblay, L.W, Blanchard, J.S.
登録日2010-06-04
公開日2011-12-14
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献BlaC-E166A covalently bound with cephalosporins and penicillins
To be Published
3NDG
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Crystal Structure of BlaC-E166A covalently bound with Methicillin
分子名称: (2R,4S)-2-[(1R)-1-{[(2,6-dimethoxyphenyl)carbonyl]amino}-2-oxoethyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid, Beta-lactamase, PHOSPHATE ION
著者Tremblay, L.W, Blanchard, J.S.
登録日2010-06-07
公開日2011-12-14
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献BlaC-E166A covalently bound with cephalosporins and penicillins
To be Published
3NBL
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Crystal Structure of BlaC-E166A covalently bound with Cefuroxime
分子名称: (2R)-5-[(carbamoyloxy)methyl]-2-[(1R)-1-{[(2Z)-2-(furan-2-yl)-2-(methoxyimino)acetyl]amino}-2-oxoethyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid, Beta-lactamase
著者Tremblay, L.W, Blanchard, J.S.
登録日2010-06-03
公開日2011-12-14
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献BlaC-E166A covalently bound with cephalosporins and penicillins
To be Published
3NC8
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Crystal Structure of BlaC-E166A covalently bound with Mecillinam
分子名称: 2-[(1R)-1-{[(E)-azepan-1-ylmethylidene]amino}-2-oxoethyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid, Beta-lactamase, PHOSPHATE ION
著者Tremblay, L.W, Blanchard, J.S.
登録日2010-06-04
公開日2011-12-14
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献BlaC-E166A covalently bound with cephalosporins and penicillins
To be Published
2W7Z
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Structure of the pentapeptide repeat protein EfsQnr, a DNA gyrase inhibitor. Free amines modified by cyclic pentylation with glutaraldehyde.
分子名称: CHLORIDE ION, PENTAPEPTIDE REPEAT FAMILY PROTEIN
著者Vetting, M.W, Hegde, S.S, Blanchard, J.S.
登録日2009-01-06
公開日2009-05-05
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Crystallization of a Pentapeptide-Repeat Protein by Reductive Cyclic Pentylation of Free Amines with Glutaraldehyde.
Acta Crystallogr.,Sect.D, 65, 2009
1TDT
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BU of 1tdt by Molmil
THREE-DIMENSIONAL STRUCTURE OF TETRAHYDRODIPICOLINATE-N-SUCCINYLTRANSFERASE
分子名称: TETRAHYDRODIPICOLINATE-N-SUCCINYLTRANSFERASE
著者Beaman, T.W, Binder, D.W, Blanchard, J.S, Roderick, S.L.
登録日1996-11-19
公開日1997-06-05
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Three-dimensional structure of tetrahydrodipicolinate N-succinyltransferase.
Biochemistry, 36, 1997
3N8R
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Crystal Structure of BlaC-E166A covalently bound with Carbenicillin
分子名称: (2R,4S)-2-[(1R)-1-{[(2S)-2-carboxy-2-phenylacetyl]amino}-2-oxoethyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid, Beta-lactamase, PHOSPHATE ION
著者Tremblay, L.W, Blanchard, J.S.
登録日2010-05-28
公開日2011-12-14
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.41 Å)
主引用文献BlaC-E166A bound with beta-lactams from all classes
To be Published
2VQY
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Structure of AAC(6')-Ib in complex with Parmomycin and AcetylCoA.
分子名称: AAC(6')-IB, ACETYL COENZYME *A, CALCIUM ION, ...
著者Vetting, M.W, Park, C.H, Hedge, S.S, Hooper, D.C, Blanchard, J.S.
登録日2008-03-20
公開日2008-09-02
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Mechanistic and Structural Analysis of Aminoglycoside N-Acetyltransferase Aac(6')-Ib and its Bifunctional, Fluoroquinolone-Active Aac(6')-Ib-Cr Variant.
Biochemistry, 47, 2008
2X9Q
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Structure of the Mycobacterium tuberculosis protein, Rv2275, demonstrates that cyclodipeptide synthetases are related to type I tRNA-Synthetases.
分子名称: CYCLODIPEPTIDE SYNTHETASE
著者Vetting, M.W, Hegde, S.S, Blanchard, J.S.
登録日2010-03-23
公開日2010-09-22
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.02 Å)
主引用文献The Structure and Mechanism of the Mycobacterium Tuberculosis Cyclodityrosine Synthetase.
Nat.Chem.Biol., 6, 2010
3N8L
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Crystal Structure of BlaC-E166A covalently bound with Ampicillin
分子名称: (2R,4S)-2-[(1R)-1-{[(2R)-2-amino-2-phenylacetyl]amino}-2-oxoethyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid, Beta-lactamase, PHOSPHATE ION
著者Tremblay, L.W, Blanchard, J.S.
登録日2010-05-28
公開日2011-12-14
最終更新日2017-11-08
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Structures of BlaC-E166A covalently bound to beta-lactams from all classes.
To be Published
3N7W
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Crystal Structure of BlaC-E166A covalently bound with Amoxicillin
分子名称: 2-{1-[2-AMINO-2-(4-HYDROXY-PHENYL)-ACETYLAMINO]-2-OXO-ETHYL}-5,5-DIMETHYL-THIAZOLIDINE-4-CARBOXYLIC ACID, Beta-lactamase, PHOSPHATE ION
著者Tremblay, L.W, Blanchard, J.S.
登録日2010-05-27
公開日2011-12-14
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献BlaC-E166A Bound with btea-lactams of all classes
To be Published
1P0H
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Crystal Structure of Rv0819 from Mycobacterium Tuberculosis MshD-Mycothiol Synthase Coenzyme A Complex
分子名称: ACETYL COENZYME *A, COENZYME A, hypothetical protein Rv0819
著者Vetting, M.W, Roderick, S.L, Yu, M, Blanchard, J.S.
登録日2003-04-10
公開日2003-09-09
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Crystal structure of mycothiol synthase (Rv0819) from Mycobacterium tuberculosis shows structural homology to the GNAT family of N-acetyltransferases.
Protein Sci., 12, 2003
3NY4
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Crystal Structure of BlaC-K73A bound with Cefamandole
分子名称: (6R,7R)-7-{[(2R)-2-hydroxy-2-phenylacetyl]amino}-3-{[(1-methyl-1H-tetrazol-5-yl)sulfanyl]methyl}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, Beta-lactamase, PHOSPHATE ION
著者Tremblay, L.W, Blanchard, J.S.
登録日2010-07-14
公開日2010-11-24
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (1.22 Å)
主引用文献Structures of the Michaelis Complex (1.2 A) and the Covalent Acyl Intermediate (2.0 A) of Cefamandole Bound in the Active Sites of the Mycobacterium tuberculosis beta-Lactamase K73A and E166A Mutants.
Biochemistry, 49, 2010

223166

件を2024-07-31に公開中

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