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PDB: 54 件
8SEH
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BU of 8seh by Molmil
PHF Tau from Down Syndrome
分子名称: Microtubule-associated protein tau
著者Hoq, M.R, Bharath, S.R, Jiang, W, Vago, F.S.
登録日2023-04-10
公開日2024-04-03
最終更新日2024-06-26
実験手法ELECTRON MICROSCOPY (2.9 Å)
主引用文献Cryo-EM structures of amyloid-beta and tau filaments in Down syndrome.
Nat.Struct.Mol.Biol., 31, 2024
8SEK
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BU of 8sek by Molmil
Type IIIa beta-amyloid 40 Filaments from Down syndrome
分子名称: Type IIIb beta-amyloid 40 Filament
著者Hoq, M.R, Vago, F.S, Bharath, S.R, Jiang, W.
登録日2023-04-10
公開日2024-04-03
最終更新日2024-06-26
実験手法ELECTRON MICROSCOPY (3.5 Å)
主引用文献Cryo-EM structures of amyloid-beta and tau filaments in Down syndrome.
Nat.Struct.Mol.Biol., 31, 2024
8SEL
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BU of 8sel by Molmil
Type IIIb beta-amyloid 40 Filaments from Down Syndrome
分子名称: Amyloid-beta protein 40
著者Hoq, M.R, Vago, F.S, Bharath, S.R, Jiang, W.
登録日2023-04-10
公開日2024-04-03
最終更新日2024-06-26
実験手法ELECTRON MICROSCOPY (3.8 Å)
主引用文献Cryo-EM structures of amyloid-beta and tau filaments in Down syndrome.
Nat.Struct.Mol.Biol., 31, 2024
5JXE
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BU of 5jxe by Molmil
Human PD-1 ectodomain complexed with Pembrolizumab Fab
分子名称: Pembrolizumab Fab heavy chain, Pembrolizumab Fab light chain, Programmed cell death protein 1
著者Na, Z, Bharath, S.R, Song, H.
登録日2016-05-13
公開日2016-08-10
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Structural basis for blocking PD-1-mediated immune suppression by therapeutic antibody pembrolizumab.
Cell Res., 27, 2017
5XX1
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BU of 5xx1 by Molmil
Crystal structure of Arginine decarboxylase (AdiA) from Salmonella typhimurium
分子名称: Arginine decarboxylase, PHOSPHATE ION
著者Deka, G, Bharath, S.R, Shavithri, H.S, Murthy, M.R.N.
登録日2017-06-30
公開日2018-05-16
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Structural studies on the decameric S. typhimurium arginine decarboxylase (ADC): Pyridoxal 5'-phosphate binding induces conformational changes
Biochem. Biophys. Res. Commun., 490, 2017
5ZMC
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BU of 5zmc by Molmil
Structural Basis for Reactivation of -146C>T Mutant TERT Promoter by cooperative binding of p52 and ETS1/2
分子名称: DNA (5'-D(P*CP*GP*GP*GP*GP*AP*CP*CP*CP*GP*GP*AP*AP*GP*GP*G)-3'), DNA (5'-D(P*GP*CP*CP*CP*TP*TP*CP*CP*GP*GP*GP*TP*CP*CP*CP*C)-3'), Nuclear factor NF-kappa-B p100 subunit, ...
著者Xu, X, Bharath, S.R, Song, H.
登録日2018-04-02
公開日2018-09-19
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.99 Å)
主引用文献Structural basis for reactivating the mutant TERT promoter by cooperative binding of p52 and ETS1.
Nat Commun, 9, 2018
7BV7
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BU of 7bv7 by Molmil
INTS3 complexed with INTS6
分子名称: Integrator complex subunit 3, Integrator complex subunit 6
著者Jia, Y, Bharath, S.R, Song, H.
登録日2020-04-09
公開日2021-07-14
最終更新日2024-05-29
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Crystal structure of the INTS3/INTS6 complex reveals the functional importance of INTS3 dimerization in DSB repair.
Cell Discov, 7, 2021
7X0F
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BU of 7x0f by Molmil
Structure of Pseudomonas NRPS protein, AmbB-TC bound to Ppant
分子名称: 4'-PHOSPHOPANTETHEINE, AMB antimetabolite synthase AmbB
著者ChuYuanKee, M, Bharath, S.R, Song, H.
登録日2022-02-22
公開日2022-06-15
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Structural insights into the substrate-bound condensation domains of non-ribosomal peptide synthetase AmbB.
Sci Rep, 12, 2022
7X0E
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Structure of Pseudomonas NRPS protein, AmbB-TC in apo form
分子名称: AMB antimetabolite synthase AmbB, N-methyl-N-[(2S,3R,4R,5R)-2,3,4,5,6-pentakis(oxidanyl)hexyl]nonanamide
著者ChuYuanKee, M, Bharath, S.R, Song, H.
登録日2022-02-22
公開日2022-07-06
最終更新日2024-05-29
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structural insights into the substrate-bound condensation domains of non-ribosomal peptide synthetase AmbB.
Sci Rep, 12, 2022
7X17
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BU of 7x17 by Molmil
Structure of Pseudomonas NRPS protein, AmbB-TC bound to Ppant-L-Ala
分子名称: AMB antimetabolite synthase AmbB, S-[2-[3-[[(2S)-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (2R)-2-azanylpropanethioate
著者ChuYuanKee, M, Bharath, S.R, Song, H.
登録日2022-02-23
公開日2022-07-13
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structural insights into the substrate-bound condensation domains of non-ribosomal peptide synthetase AmbB.
Sci Rep, 12, 2022
5FHF
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Crystal structure of Bacteroides sp Pif1 in complex with ADP-AlF4
分子名称: ADENOSINE-5'-DIPHOSPHATE, TETRAFLUOROALUMINATE ION, Uncharacterized protein
著者Zhou, X, Ren, W, Bharath, S.R, Song, H.
登録日2015-12-22
公開日2016-03-30
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (2.15 Å)
主引用文献Structural and Functional Insights into the Unwinding Mechanism of Bacteroides sp Pif1
Cell Rep, 14, 2016
5FHE
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BU of 5fhe by Molmil
Crystal structure of Bacteroides Pif1 bound to ssDNA
分子名称: ADENOSINE-5'-DIPHOSPHATE, DNA (5'-D(P*TP*TP*TP*TP*TP*TP*TP*TP*TP*T)-3'), MAGNESIUM ION, ...
著者Zhou, X, Ren, W, Bharath, S.R, Song, H.
登録日2015-12-22
公開日2016-03-30
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Structural and Functional Insights into the Unwinding Mechanism of Bacteroides sp Pif1
Cell Rep, 14, 2016
5FHG
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BU of 5fhg by Molmil
Structure of unliganded Pif1 from Bacteroides sp
分子名称: Uncharacterized protein
著者Zhou, X, Ren, W, Bharath, S.R, Song, H.
登録日2015-12-22
公開日2016-03-30
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structural and Functional Insights into the Unwinding Mechanism of Bacteroides sp Pif1
Cell Rep, 14, 2016
7UN5
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BU of 7un5 by Molmil
Structure of Type II Prion filaments from Gerstmann-Straussler-Scheinker disease
分子名称: Major prion protein
著者Ozcan, K.A, Hoq, M.R, Bharath, S.R, Jiang, W.
登録日2022-04-08
公開日2022-07-27
最終更新日2024-03-27
実験手法ELECTRON MICROSCOPY (3.13 Å)
主引用文献Cryo-EM structures of prion protein filaments from Gerstmann-Straussler-Scheinker disease.
Acta Neuropathol, 144, 2022
7UMQ
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BU of 7umq by Molmil
Structure of Type I Prion filaments from Gerstmann-Straussler-Scheinker disease
分子名称: Major prion protein
著者Ozcan, K.A, Hoq, M.R, Bharath, S.R, Jiang, W.
登録日2022-04-07
公開日2022-07-27
最終更新日2024-03-27
実験手法ELECTRON MICROSCOPY (3.29 Å)
主引用文献Cryo-EM structures of prion protein filaments from Gerstmann-Straussler-Scheinker disease.
Acta Neuropathol, 144, 2022
5FHH
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BU of 5fhh by Molmil
Structure of human Pif1 helicase domain residues 200-641
分子名称: ADENOSINE-5'-DIPHOSPHATE, ATP-dependent DNA helicase PIF1, TETRAFLUOROALUMINATE ION
著者Zhou, X, Ren, W, Bharath, S.R, Song, H.
登録日2015-12-22
公開日2016-03-30
実験手法X-RAY DIFFRACTION (3.6 Å)
主引用文献Structural and Functional Insights into the Unwinding Mechanism of Bacteroides sp Pif1
Cell Rep, 14, 2016
5FHD
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BU of 5fhd by Molmil
Structure of Bacteroides sp Pif1 complexed with tailed dsDNA resulting in ssDNA bound complex
分子名称: ADENOSINE-5'-DIPHOSPHATE, DNA (5'-D(*TP*TP*TP*TP*TP*TP*TP*CP*CP*GP*GP*GP*GP*CP*CP*GP*CP*GP*C)-3'), MAGNESIUM ION, ...
著者Zhou, X, Ren, W, Bharath, S.R, Song, H.
登録日2015-12-22
公開日2016-03-30
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structural and Functional Insights into the Unwinding Mechanism of Bacteroides sp Pif1
Cell Rep, 14, 2016
4JEX
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BU of 4jex by Molmil
Y21K mutant of N-acetylornithine aminotransferase complexed with L-canaline
分子名称: (2S)-2-azanyl-4-[(E)-[2-methyl-3-oxidanyl-5-(phosphonooxymethyl)pyridin-4-yl]methylideneamino]oxy-butanoic acid, 1,2-ETHANEDIOL, ACETATE ION, ...
著者Bisht, S, Bharath, S.R, Murthy, M.R.N.
登録日2013-02-27
公開日2014-03-26
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (1.43 Å)
主引用文献Conformational transitions, ligand specificity and catalysis in N-acetylornithine aminotransferase: Implications on drug designing and rational enzyme engineering in omega aminotransferases
To be Published
4JEZ
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BU of 4jez by Molmil
N79R mutant of N-acetylornithine aminotransferase complexed with L-canaline
分子名称: (2S)-2-azanyl-4-[(E)-[2-methyl-3-oxidanyl-5-(phosphonooxymethyl)pyridin-4-yl]methylideneamino]oxy-butanoic acid, 1,2-ETHANEDIOL, ACETATE ION, ...
著者Bisht, S, Bharath, S.R, Murthy, M.R.N.
登録日2013-02-27
公開日2014-03-26
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (1.55 Å)
主引用文献Conformational transitions, ligand specificity and catalysis in N-acetylornithine aminotransferase: Implications on drug designing and rational enzyme engineering in omega aminotransferases
To be Published
4JEV
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BU of 4jev by Molmil
N-acetylornithine aminotransferase from S. typhimurium complexed with gabaculine
分子名称: 3-[O-PHOSPHONOPYRIDOXYL]--AMINO-BENZOIC ACID, ACETATE ION, Acetylornithine/succinyldiaminopimelate aminotransferase, ...
著者Bisht, S, Bharath, S.R, Murthy, M.R.N.
登録日2013-02-27
公開日2014-03-26
最終更新日2023-12-06
実験手法X-RAY DIFFRACTION (1.67 Å)
主引用文献Conformational transitions, ligand specificity and catalysis in N-acetylornithine aminotransferase: Implications on drug designing and rational enzyme engineering in omega aminotransferases.
To be Published
4JF1
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BU of 4jf1 by Molmil
R144Q mutant of N-acetylornithine aminotransferase
分子名称: 1,2-ETHANEDIOL, ACETATE ION, Acetylornithine/succinyldiaminopimelate aminotransferase, ...
著者Bisht, S, Bharath, S.R, Murthy, M.R.N.
登録日2013-02-27
公開日2014-03-26
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (1.28 Å)
主引用文献Conformational transitions, ligand specificity and catalysis in N-acetylornithine aminotransferase: Implications on drug designing and rational enzyme engineering in omega aminotransferases
To be Published
4JF0
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BU of 4jf0 by Molmil
N79R mutant of N-acetylornithine aminotransferase
分子名称: 1,2-ETHANEDIOL, ACETATE ION, Acetylornithine/succinyldiaminopimelate aminotransferase, ...
著者Bisht, S, Bharath, S.R, Murthy, M.R.N.
登録日2013-02-27
公開日2014-03-26
最終更新日2023-12-06
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Conformational transitions, ligand specificity and catalysis in N-acetylornithine aminotransferase: Implications on drug designing and rational enzyme engineering in omega aminotransferases
To be Published
4JEW
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BU of 4jew by Molmil
N-acetylornithine aminotransferase from S. typhimurium complexed with L-canaline
分子名称: (2S)-2-azanyl-4-[(E)-[2-methyl-3-oxidanyl-5-(phosphonooxymethyl)pyridin-4-yl]methylideneamino]oxy-butanoic acid, 1,2-ETHANEDIOL, ACETATE ION, ...
著者Bisht, S, Bharath, S.R, Murthy, M.R.N.
登録日2013-02-27
公開日2014-03-26
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (1.48 Å)
主引用文献Conformational transitions, ligand specificity and catalysis in N-acetylornithine aminotransferase: Implications on drug designing and rational enzyme engineering in omega aminotransferases.
To be Published
4JEY
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BU of 4jey by Molmil
E198A mutant of N-acetylornithine aminotransferase from Salmonella typhimurium
分子名称: 1,2-ETHANEDIOL, ACETATE ION, Acetylornithine/succinyldiaminopimelate aminotransferase, ...
著者Bisht, S, Bharath, S.R, Murthy, M.R.N.
登録日2013-02-27
公開日2014-03-26
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (1.55 Å)
主引用文献Conformational transitions, ligand specificity and catalysis in N-acetylornithine aminotransferase: Implications on drug designing and rational enzyme engineering in omega aminotransferases
To be Published
4D9I
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BU of 4d9i by Molmil
Crystal structure of holo Diaminopropionate ammonia lyase from Escherichia coli
分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Diaminopropionate ammonia-lyase
著者Bisht, S, Rajaram, V, Bharath, S.R, Murthy, M.R.N.
登録日2012-01-11
公開日2012-04-25
最終更新日2023-12-06
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Crystal Structure of Escherichia coli Diaminopropionate Ammonia-lyase Reveals Mechanism of Enzyme Activation and Catalysis
J.Biol.Chem., 287, 2012

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件を2024-09-04に公開中

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