7UMQ

Structure of Type I Prion filaments from Gerstmann-Straussler-Scheinker disease

Summary for 7UMQ

• Entry DOI: 10.2210/pdb7umq/pdb
• EMDB information: 26607
• Descriptor: Major prion protein (1 entity in total)
• Functional Keywords: prion, prp, gss, filament, fibril, human brain derived, neurodegenerative, protein fibril
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 10
• Total formula weight: 62190.43

Authors

Ozcan, K.A.,Hoq, M.R.,Bharath, S.R.,Jiang, W. (deposition date: 2022-04-07, release date: 2022-07-27, Last modification date: 2024-03-27)

• Primary citation: Hallinan, G.I.,Ozcan, K.A.,Hoq, M.R.,Cracco, L.,Vago, F.S.,Bharath, S.R.,Li, D.,Jacobsen, M.,Doud, E.H.,Mosley, A.L.,Fernandez, A.,Garringer, H.J.,Jiang, W.,Ghetti, B.,Vidal, R.; Cryo-EM structures of prion protein filaments from Gerstmann-Straussler-Scheinker disease.; Acta Neuropathol, 144:509-520, 2022; PubMed: 35819518; DOI: 10.1007/s00401-022-02461-0

Experimental method

ELECTRON MICROSCOPY (3.29 Å)