5ZMC
Structural Basis for Reactivation of -146C>T Mutant TERT Promoter by cooperative binding of p52 and ETS1/2
Summary for 5ZMC
Entry DOI | 10.2210/pdb5zmc/pdb |
Descriptor | DNA (5'-D(P*CP*GP*GP*GP*GP*AP*CP*CP*CP*GP*GP*AP*AP*GP*GP*G)-3'), DNA (5'-D(P*GP*CP*CP*CP*TP*TP*CP*CP*GP*GP*GP*TP*CP*CP*CP*C)-3'), Protein C-ets-1, ... (4 entities in total) |
Functional Keywords | ets1, p52, transcription factor, transcription, -146c>t mutant tert promoter activation, transcription-dna complex, transcription/dna |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 4 |
Total formula weight | 56082.24 |
Authors | Xu, X.,Bharath, S.R.,Song, H. (deposition date: 2018-04-02, release date: 2018-09-19, Last modification date: 2023-11-22) |
Primary citation | Xu, X.,Li, Y.,Bharath, S.R.,Ozturk, M.B.,Bowler, M.W.,Loo, B.Z.L.,Tergaonkar, V.,Song, H. Structural basis for reactivating the mutant TERT promoter by cooperative binding of p52 and ETS1. Nat Commun, 9:3183-3183, 2018 Cited by PubMed: 30093619DOI: 10.1038/s41467-018-05644-0 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.99 Å) |
Structure validation
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