5ZMC

Structural Basis for Reactivation of -146C>T Mutant TERT Promoter by cooperative binding of p52 and ETS1/2

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0003700	molecular_function	DNA-binding transcription factor activity
A	0005737	cellular_component	cytoplasm
A	0006355	biological_process	regulation of DNA-templated transcription
B	0003700	molecular_function	DNA-binding transcription factor activity
B	0006355	biological_process	regulation of DNA-templated transcription
B	0006357	biological_process	regulation of transcription by RNA polymerase II
B	0043565	molecular_function	sequence-specific DNA binding

Functional Information from PROSITE/UniProt

site_id	PS00345
Number of Residues	9
Details	ETS_DOMAIN_1 Ets-domain signature 1. LWQFLLELL

Chain	Residue	Details
B	LEU337-LEU345

---

site_id	PS00346
Number of Residues	16
Details	ETS_DOMAIN_2 Ets-domain signature 2. KpkMnYEkLSRGLRyY

Chain	Residue	Details
B	LYS381-TYR396

---

site_id	PS01204
Number of Residues	7
Details	REL_1 NF-kappa-B/Rel/dorsal domain signature. FRYgCEG

Chain	Residue	Details
A	PHE53-GLY59

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	80
Details	DNA binding: {"description":"ETS","evidences":[{"source":"PROSITE-ProRule","id":"PRU00237","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	Region: {"description":"Helix H4","evidences":[{"source":"UniProtKB","id":"P27577","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	6
Details	Region: {"description":"Helix H5","evidences":[{"source":"UniProtKB","id":"P27577","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---