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PDB: 16 件
6MWW
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LasR LBD:BB0126 complex
分子名称: 4-[3-(methylsulfonyl)phenoxy]-N-[(1R,3R,5R)-2-oxobicyclo[3.1.0]hexan-3-yl]butanamide, Transcriptional regulator LasR
著者Bassler, B.L, Paczkowski, J.E.
登録日2018-10-30
公開日2019-04-03
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (2.76 Å)
主引用文献An Autoinducer Analogue Reveals an Alternative Mode of Ligand Binding for the LasR Quorum-Sensing Receptor.
Acs Chem.Biol., 14, 2019
6MWH
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LasR LBD:BB0020 complex
分子名称: 2-(3-bromophenoxy)-N-[(1S,2S,3R,5S)-2-hydroxybicyclo[3.1.0]hexan-3-yl]acetamide, Transcriptional regulator LasR
著者Bassler, B.L, Paczkowski, J.E.
登録日2018-10-29
公開日2019-04-03
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献An Autoinducer Analogue Reveals an Alternative Mode of Ligand Binding for the LasR Quorum-Sensing Receptor.
Acs Chem.Biol., 14, 2019
6MVN
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LasR LBD L130F:3OC10HSL complex
分子名称: 3-oxo-N-[(3S)-2-oxotetrahydrofuran-3-yl]decanamide, Transcriptional regulator LasR
著者Bassler, B.L, Paczkowski, J.E.
登録日2018-10-26
公開日2019-01-16
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Structural determinants driving homoserine lactone ligand selection in thePseudomonas aeruginosaLasR quorum-sensing receptor.
Proc. Natl. Acad. Sci. U.S.A., 116, 2019
6MWL
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LasR LBD:mBTL complex
分子名称: 4-(3-bromophenoxy)-N-[(3S)-2-oxothiolan-3-yl]butanamide, Transcriptional regulator LasR
著者Bassler, B.L, Paczkowski, J.E.
登録日2018-10-29
公開日2019-04-03
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献An Autoinducer Analogue Reveals an Alternative Mode of Ligand Binding for the LasR Quorum-Sensing Receptor.
Acs Chem.Biol., 14, 2019
6MWZ
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LasR LBD T75V/Y93F/A127W:BB0126
分子名称: 4-[3-(methylsulfonyl)phenoxy]-N-[(1S,3S,5S)-2-oxobicyclo[3.1.0]hexan-3-yl]butanamide, ALA-HIS-HIS-HIS-HIS-ALA, Transcriptional regulator LasR
著者Bassler, B.L, Paczkowski, J.E.
登録日2018-10-30
公開日2019-04-03
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (1.657 Å)
主引用文献An Autoinducer Analogue Reveals an Alternative Mode of Ligand Binding for the LasR Quorum-Sensing Receptor.
Acs Chem.Biol., 14, 2019
1Y6D
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Solution structure and dynamics of LuxU from Vibrio harveyi, a phosphotransferase protein involved in bacterial quorum sensing
分子名称: Phosphorelay protein luxU
著者Ulrich, D.L, Kojetin, D, Bassler, B.L, Cavanagh, J, Loria, J.P.
登録日2004-12-06
公開日2004-12-14
最終更新日2024-05-22
実験手法SOLUTION NMR
主引用文献Solution structure and dynamics of LuxU from Vibrio harveyi, a phosphotransferase protein involved in bacterial quorum sensing.
J.Mol.Biol., 347, 2005
1JX6
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CRYSTAL STRUCTURE OF LUXP FROM VIBRIO HARVEYI COMPLEXED WITH AUTOINDUCER-2
分子名称: 3A-METHYL-5,6-DIHYDRO-FURO[2,3-D][1,3,2]DIOXABOROLE-2,2,6,6A-TETRAOL, CALCIUM ION, LUXP PROTEIN
著者Chen, X, Schauder, S, Potier, N, Van Dorsselaer, A, Pelczer, I, BassleR, B.L, Hughson, F.M.
登録日2001-09-05
公開日2002-02-04
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Structural identification of a bacterial quorum-sensing signal containing boron.
Nature, 415, 2002
1ZHH
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Crystal Structure of the Apo Form of Vibrio Harveyi LUXP Complexed with the Periplasmic Domain of LUXQ
分子名称: 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, Autoinducer 2 sensor kinase/phosphatase luxQ, Autoinducer 2-binding periplasmic protein luxP
著者Neiditch, M.B, Federle, M.J, Miller, S.T, Bassler, B.L, Hughson, F.M.
登録日2005-04-25
公開日2005-05-24
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (1.94 Å)
主引用文献Regulation of LuxPQ Receptor Activity by the Quorum-Sensing Signal Autoinducer-2.
Mol.Cell, 18, 2005
7TZ9
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Structure of PQS Response Protein PqsE(E182W) Variant
分子名称: FE (III) ION, Quinolone signal response protein
著者Jeffrey, P.D, Taylor, I.R, Bassler, B.L.
登録日2022-02-15
公開日2022-08-31
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.01 Å)
主引用文献The PqsE Active Site as a Target for Small Molecule Antimicrobial Agents against Pseudomonas aeruginosa.
Biochemistry, 61, 2022
7TZA
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Structure of PQS Response Protein PqsE in complex with N-(4-(3-neopentylureido)phenyl)-1H-indazole-7-carboxamide
分子名称: 1,2-ETHANEDIOL, FE (III) ION, N-{4-[(2,2-dimethylpropyl)carbamamido]phenyl}-1H-indazole-7-carboxamide, ...
著者Jeffrey, P.D, Taylor, I.R, Bassler, B.L.
登録日2022-02-15
公開日2022-08-31
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献The PqsE Active Site as a Target for Small Molecule Antimicrobial Agents against Pseudomonas aeruginosa.
Biochemistry, 61, 2022
7U6G
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Structure of PQS Response Protein PqsE(E182W,E280A) Variant
分子名称: FE (III) ION, Quinolone signal response protein
著者Jeffrey, P.D, Taylor, I.R, Bassler, B.L.
登録日2022-03-04
公開日2022-08-31
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.45 Å)
主引用文献The PqsE Active Site as a Target for Small Molecule Antimicrobial Agents against Pseudomonas aeruginosa.
Biochemistry, 61, 2022
1TM2
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Crystal Structure of the apo form of the Salmonella typhimurium AI-2 receptor LsrB
分子名称: sugar transport protein
著者Miller, S.T, Xavier, K.B, Campagna, S.R, Taga, M.E, Semmelhack, M.F, Bassler, B.L, Hughson, F.M.
登録日2004-06-10
公開日2004-09-28
最終更新日2018-01-31
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Salmonella typhimurium Recognizes a Chemically Distinct Form of the Bacterial Quorum-Sensing Signal AI-2
Mol.Cell, 15, 2004
1TJY
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Crystal Structure of Salmonella typhimurium AI-2 receptor LsrB in complex with R-THMF
分子名称: (2R,4S)-2-methyl-2,3,3,4-tetrahydroxytetrahydrofuran, sugar transport protein
著者Miller, S.T, Xavier, K.B, Campagna, S.R, Taga, M.E, Semmelhack, M.F, Bassler, B.L, Hughson, F.M.
登録日2004-06-07
公開日2004-09-28
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (1.3 Å)
主引用文献Salmonella typhimurium Recognizes a Chemically Distinct Form of the Bacterial Quorum-Sensing Signal AI-2
Mol.Cell, 15, 2004
6MVM
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LasR LBD L130F:3OC14HSL complex
分子名称: 3-oxo-N-[(3S)-2-oxooxolan-3-yl]tetradecanamide, Transcriptional regulator LasR
著者Paczkowski, J.E, Bassler, B.L.
登録日2018-10-26
公開日2019-01-16
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.895 Å)
主引用文献An Autoinducer Analogue Reveals an Alternative Mode of Ligand Binding for the LasR Quorum-Sensing Receptor.
Acs Chem.Biol., 14, 2019
7KGX
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Structure of PQS Response Protein PqsE in Complex with 4-(3-(2-methyl-2-morpholinobutyl)ureido)-N-(thiazol-2-yl)benzamide
分子名称: 2-aminobenzoylacetyl-CoA thioesterase, 4-({[(2R)-2-methyl-2-(morpholin-4-yl)butyl]carbamoyl}amino)-N-(1,3-thiazol-2-yl)benzamide, FE (III) ION
著者Jeffrey, P.D, Taylor, I.R, Bassler, B.L.
登録日2020-10-19
公開日2021-05-05
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Inhibitor Mimetic Mutations in the Pseudomonas aeruginosa PqsE Enzyme Reveal a Protein-Protein Interaction with the Quorum-Sensing Receptor RhlR That Is Vital for Virulence Factor Production.
Acs Chem.Biol., 16, 2021
7KGW
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Structure of PQS Response Protein PqsE in Complex N-(3-(1H-pyrazol-5-yl)phenyl)-1H-indazole-7-carboxamide
分子名称: 2-aminobenzoylacetyl-CoA thioesterase, FE (III) ION, N-[3-(1H-pyrazol-3-yl)phenyl]-1H-indazole-7-carboxamide
著者Jeffrey, P.D, Taylor, I.R, Bassler, B.L.
登録日2020-10-19
公開日2021-05-05
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.99 Å)
主引用文献Inhibitor Mimetic Mutations in the Pseudomonas aeruginosa PqsE Enzyme Reveal a Protein-Protein Interaction with the Quorum-Sensing Receptor RhlR That Is Vital for Virulence Factor Production.
Acs Chem.Biol., 16, 2021

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件を2024-07-03に公開中

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