7TZA

Structure of PQS Response Protein PqsE in complex with N-(4-(3-neopentylureido)phenyl)-1H-indazole-7-carboxamide

Summary for 7TZA

• Entry DOI: 10.2210/pdb7tza/pdb
• Related: 7KGW 7KGX
• Descriptor: Quinolone signal response protein, FE (III) ION, N-{4-[(2,2-dimethylpropyl)carbamamido]phenyl}-1H-indazole-7-carboxamide, ... (5 entities in total)
• Functional Keywords: quorum sensing, pqs, pqse, inhibitor, hydrolase-inhibitor complex, hydrolase, hydrolase/inhibitor
• Biological source: Pseudomonas aeruginosa
• Total number of polymer chains: 1
• Total formula weight: 35171.76

Authors

Jeffrey, P.D.,Taylor, I.R.,Bassler, B.L. (deposition date: 2022-02-15, release date: 2022-08-31, Last modification date: 2023-10-18)

• Primary citation: Taylor, I.R.,Jeffrey, P.D.,Moustafa, D.A.,Goldberg, J.B.,Bassler, B.L.; The PqsE Active Site as a Target for Small Molecule Antimicrobial Agents against Pseudomonas aeruginosa.; Biochemistry, 61:1894-1903, 2022; PubMed: 35985643; DOI: 10.1021/acs.biochem.2c00334

Experimental method

X-RAY DIFFRACTION (2.1 Å)