7KGW
Structure of PQS Response Protein PqsE in Complex N-(3-(1H-pyrazol-5-yl)phenyl)-1H-indazole-7-carboxamide
Summary for 7KGW
Entry DOI | 10.2210/pdb7kgw/pdb |
Related | 7KGX |
Descriptor | 2-aminobenzoylacetyl-CoA thioesterase, FE (III) ION, N-[3-(1H-pyrazol-3-yl)phenyl]-1H-indazole-7-carboxamide, ... (4 entities in total) |
Functional Keywords | quorum sensing, pqs, pqse, inhibitor, metal binding protein, hydrolase-inhibitor complex, hydrolase/inhibitor |
Biological source | Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) |
Total number of polymer chains | 1 |
Total formula weight | 35047.58 |
Authors | Jeffrey, P.D.,Taylor, I.R.,Bassler, B.L. (deposition date: 2020-10-19, release date: 2021-05-05, Last modification date: 2023-10-18) |
Primary citation | Taylor, I.R.,Paczkowski, J.E.,Jeffrey, P.D.,Henke, B.R.,Smith, C.D.,Bassler, B.L. Inhibitor Mimetic Mutations in the Pseudomonas aeruginosa PqsE Enzyme Reveal a Protein-Protein Interaction with the Quorum-Sensing Receptor RhlR That Is Vital for Virulence Factor Production. Acs Chem.Biol., 16:740-752, 2021 Cited by PubMed: 33793200DOI: 10.1021/acschembio.1c00049 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.99 Å) |
Structure validation
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