7KGW

Structure of PQS Response Protein PqsE in Complex N-(3-(1H-pyrazol-5-yl)phenyl)-1H-indazole-7-carboxamide

Summary for 7KGW

• Entry DOI: 10.2210/pdb7kgw/pdb
• Related: 7KGX
• Descriptor: 2-aminobenzoylacetyl-CoA thioesterase, FE (III) ION, N-[3-(1H-pyrazol-3-yl)phenyl]-1H-indazole-7-carboxamide, ... (4 entities in total)
• Functional Keywords: quorum sensing, pqs, pqse, inhibitor, metal binding protein, hydrolase-inhibitor complex, hydrolase/inhibitor
• Biological source: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
• Total number of polymer chains: 1
• Total formula weight: 35047.58

Authors

Jeffrey, P.D.,Taylor, I.R.,Bassler, B.L. (deposition date: 2020-10-19, release date: 2021-05-05, Last modification date: 2023-10-18)

• Primary citation: Taylor, I.R.,Paczkowski, J.E.,Jeffrey, P.D.,Henke, B.R.,Smith, C.D.,Bassler, B.L.; Inhibitor Mimetic Mutations in the Pseudomonas aeruginosa PqsE Enzyme Reveal a Protein-Protein Interaction with the Quorum-Sensing Receptor RhlR That Is Vital for Virulence Factor Production.; Acs Chem.Biol., 16:740-752, 2021; PubMed: 33793200; DOI: 10.1021/acschembio.1c00049

Experimental method

X-RAY DIFFRACTION (1.99 Å)