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PDB: 152 件
2JDS
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Structure of cAMP-dependent protein kinase complexed with A-443654
分子名称: (2S)-1-(1H-INDOL-3-YL)-3-{[5-(3-METHYL-1H-INDAZOL-5-YL)PYRIDIN-3-YL]OXY}PROPAN-2-AMINE, CAMP-DEPENDENT PROTEIN KINASE, CAMP-DEPENDENT PROTEIN KINASE INHIBITOR ALPHA
著者Davies, T.G, Verdonk, M.L, Graham, B, Saalau-Bethell, S, Hamlett, C.C.F, McHardy, T, Collins, I, Garrett, M.D, Workman, P, Woodhead, S.J, Jhoti, H, Barford, D.
登録日2007-01-12
公開日2007-02-13
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献A Structural Comparison of Inhibitor Binding to Pkb, Pka and Pka-Pkb Chimera
J.Mol.Biol., 367, 2007
2JDT
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Structure of PKA-PKB chimera complexed with ISOQUINOLINE-5-SULFONIC ACID (2-(2-(4-CHLOROBENZYLOXY) ETHYLAMINO)ETHYL)AMIDE
分子名称: CAMP-DEPENDENT PROTEIN KINASE, CAMP-DEPENDENT PROTEIN KINASE INHIBITOR ALPHA, ISOQUINOLINE-5-SULFONIC ACID (2-(2-(4-CHLOROBENZYLOXY)ETHYLAMINO)ETHYL)AMIDE
著者Davies, T.G, Verdonk, M.L, Graham, B, Saalau-Bethell, S, Hamlett, C.C.F, McHardy, T, Collins, I, Garrett, M.D, Workman, P, Woodhead, S.J, Jhoti, H, Barford, D.
登録日2007-01-12
公開日2007-02-13
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.15 Å)
主引用文献A Structural Comparison of Inhibitor Binding to Pkb, Pka and Pka-Pkb Chimera
J.Mol.Biol., 367, 2007
2XPI
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Crystal structure of APC/C hetero-tetramer Cut9-Hcn1
分子名称: ANAPHASE-PROMOTING COMPLEX SUBUNIT CUT9, ANAPHASE-PROMOTING COMPLEX SUBUNIT HCN1 HCN1/CDC26,20S CYCLOSOME/APC COMPLEX PROTEIN HCN1, CHAPERONE-LIKE PROTEIN HCN1, ...
著者Zhang, Z, Kulkarni, K.A, Barford, D.
登録日2010-08-26
公開日2011-03-30
最終更新日2019-04-03
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献The Apc/C Subunit Cdc16/Cut9 is a Contiguous Tetratricopeptide Superhelix with a Homo-Dimer Interface Similar to Cdc27
Embo J., 29, 2010
2VFJ
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Structure of the A20 Ovarian Tumour (OTU) domain
分子名称: MAGNESIUM ION, SULFATE ION, TUMOR NECROSIS FACTOR
著者Komander, D, Barford, D.
登録日2007-11-04
公開日2007-12-04
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Structure of the A20 Otu Domain and Mechanistic Insights Into Deubiquitination
Biochem.J., 409, 2008
2IXP
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Crystal structure of the Pp2A phosphatase activator Ypa1 PTPA1 in complex with model substrate
分子名称: CHLORIDE ION, SERINE/THREONINE-PROTEIN PHOSPHATASE 2A ACTIVATOR 1, SIN-ALA-ALA-PRO-LYS-NIT, ...
著者Leulliot, N, Vicentini, G, Jordens, J, Quevillon-Cheruel, S, Schiltz, M, Barford, D, Van Tilbeurgh, H, Goris, J.
登録日2006-07-09
公開日2006-07-31
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Crystal structure of the PP2A phosphatase activator: implications for its PP2A-specific PPIase activity.
Mol. Cell, 23, 2006
2V55
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Mechanism of multi-site phosphorylation from a ROCK-I:RhoE complex structure
分子名称: GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ...
著者Komander, D, Garg, R, Wan, P.T.C, Ridley, A.J, Barford, D.
登録日2008-10-01
公開日2008-11-04
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (3.705 Å)
主引用文献Mechanism of Multi-Site Phosphorylation from a Rock-I:Rhoe Complex Structure.
Embo J., 27, 2008
2W9N
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crystal structure of linear di-ubiquitin
分子名称: CHLORIDE ION, UBIQUITIN, ZINC ION
著者Komander, D, Reyes-Turcu, F, Wilkinson, K.D, Barford, D.
登録日2009-01-27
公開日2009-04-28
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献Molecular Discrimination of Structurally Equivalent Lys 63-Linked and Linear Polyubiquitin Chains.
Embo Rep., 10, 2009
2UW4
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Structure of PKA-PKB chimera complexed with 2-(4-(5-methyl-1H-pyrazol- 4-yl)-phenyl)-ethylamine
分子名称: 2-[4-(3-METHYL-1H-PYRAZOL-4-YL)PHENYL]ETHANAMINE, CAMP-DEPENDENT PROTEIN KINASE INHIBITOR ALPHA, CAMP-DEPENDENT PROTEIN KINASE, ...
著者Davies, T.G, Saxty, G, Woodhead, S.J, Berdini, V, Verdonk, M.L, Wyatt, P.G, Boyle, R.G, Barford, D, Downham, R, Garrett, M.D, Carr, R.A.
登録日2007-03-19
公開日2007-05-08
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Identification of Inhibitors of Protein Kinase B Using Fragment-Based Lead Discovery
J.Med.Chem., 50, 2007
2UW5
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Structure of PKA-PKB chimera complexed with (R)-2-(4-chloro-phenyl)- 2-(4-1H-pyrazol-4-yl)-phenyl)-ethylamine
分子名称: (2R)-2-(4-CHLOROPHENYL)-2-[4-(1H-PYRAZOL-4-YL)PHENYL]ETHANAMINE, CAMP-DEPENDENT PROTEIN KINASE INHIBITOR ALPHA, CAMP-DEPENDENT PROTEIN KINASE, ...
著者Davies, T.G, Saxty, G, Woodhead, S.J, Berdini, V, Verdonk, M.L, Wyatt, P.G, Boyle, R.G, Barford, D, Downham, R, Garrett, M.D, Carr, R.A.
登録日2007-03-19
公開日2007-05-08
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.14 Å)
主引用文献Identification of Inhibitors of Protein Kinase B Using Fragment-Based Lead Discovery
J.Med.Chem., 50, 2007
2UW7
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Structure of PKA-PKB chimera complexed with 4-(4-chloro-phenyl)-4-(4- (1H-pyrazol-4-yl)-phenyl)-piperidine
分子名称: 4-(4-CHLOROPHENYL)-4-[4-(1H-PYRAZOL-4-YL)PHENYL]PIPERIDINE, CAMP-DEPENDENT PROTEIN KINASE INHIBITOR ALPHA, CAMP-DEPENDENT PROTEIN KINASE, ...
著者Davies, T.G, Saxty, G, Woodhead, S.J, Berdini, V, Verdonk, M.L, Wyatt, P.G, Boyle, R.G, Barford, D, Downham, R, Garrett, M.D, Carr, R.A.
登録日2007-03-19
公開日2007-05-08
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Identification of Inhibitors of Protein Kinase B Using Fragment-Based Lead Discovery
J.Med.Chem., 50, 2007
2VFY
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AKAP18 delta central domain
分子名称: AKAP18 DELTA
著者Gold, M.G, Smith, F.D, Scott, J.D, Barford, D.
登録日2007-11-06
公開日2008-05-06
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Akap18 Contains a Phosphoesterase Domain that Binds AMP
J.Mol.Biol., 375, 2008
2IXO
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CRYSTAL STRUCTURE OF THE PP2A PHOSPHATASE ACTIVATOR Ypa1 PTPA1
分子名称: SERINE/THREONINE-PROTEIN PHOSPHATASE 2A ACTIVATOR 1
著者Leulliot, N, Vicentini, G, Jordens, J, Quevillon-Cheruel, S, Schiltz, M, Barford, D, Van Tilbeurgh, H, Goris, J.
登録日2006-07-09
公開日2006-07-31
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Crystal Structure of the Pp2A Phosphatase Activator: Implications for its Pp2A-Specific Ppiase Activity.
Mol.Cell, 23, 2006
2W42
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THE STRUCTURE OF A PIWI PROTEIN FROM ARCHAEOGLOBUS FULGIDUS COMPLEXED WITH A 16NT DNA DUPLEX.
分子名称: 5'-D(*GP*TP*CP*GP*AP*AP*TP*TP)-3', 5'-D(*TP*TP*CP*GP*AP*CP*GP*CP)-3', MANGANESE (II) ION, ...
著者Parker, J.S, Roe, S.M, Barford, D.
登録日2008-11-19
公開日2008-12-09
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Enhancement of the Seed-Target Recognition Step in RNA Silencing by a Piwi-Mid Domain Protein
Mol.Cell, 33, 2009
2VSZ
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Crystal Structure of the ELMO1 PH domain
分子名称: ENGULFMENT AND CELL MOTILITY PROTEIN 1
著者Komander, D, Patel, M, Barford, D, Cote, J.-F.
登録日2008-05-01
公開日2009-03-10
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献An Alpha-Helical Extension of the Elmo1 Pleckstrin Homology Domain Mediates Direct Interaction to Dock180 and is Critical in Rac Signaling.
Molecular Biology of the Cell, 19, 2008
2V0P
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The Structure of Tap42 Alpha4 Subunit
分子名称: TYPE 2A PHOSPHATASE-ASSOCIATED PROTEIN 42, ZINC ION
著者Roe, S.M, Yang, J, Barford, D.
登録日2007-05-15
公開日2007-07-17
最終更新日2019-05-15
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献The Structure of Tap42/Alpha4 Reveals a Tetratricopeptide Repeat-Like Fold and Provides Insights Into Pp2A Regulation.
Biochemistry, 46, 2007
2VHF
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Structure of the CYLD USP domain
分子名称: UBIQUITIN CARBOXYL-TERMINAL HYDROLASE CYLD, ZINC ION
著者Komander, D, Lord, C.J, Scheel, H, Swift, S, Hofmann, K, Ashworth, A, Barford, D.
登録日2007-11-21
公開日2008-03-11
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献The Structure of the Cyld Usp Domain Explains its Specificity for Lys63-Linked Polyubiquitin and Reveals a B-Box Module
Mol.Cell.Biol., 29, 2008
2UW6
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Structure of PKA-PKB chimera complexed with (S)-2-(4-chloro-phenyl)- 2-(4-1H-pyrazol-4-yl)-phenyl)-ethylamine
分子名称: (2S)-2-(4-CHLOROPHENYL)-2-[4-(1H-PYRAZOL-4-YL)PHENYL]ETHANAMINE, CAMP-DEPENDENT PROTEIN KINASE INHIBITOR ALPHA, CAMP-DEPENDENT PROTEIN KINASE, ...
著者Davies, T.G, Saxty, G, Woodhead, S.J, Berdini, V, Verdonk, M.L, Wyatt, P.G, Boyle, R.G, Barford, D, Downham, R, Garrett, M.D, Carr, R.A.
登録日2007-03-19
公開日2007-05-08
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.23 Å)
主引用文献Identification of Inhibitors of Protein Kinase B Using Fragment-Based Lead Discovery
J.Med.Chem., 50, 2007
2UW9
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STRUCTURE OF PKB-BETA (AKT2) COMPLEXED WITH 4-(4-chloro-phenyl)-4-(4-(1H-pyrazol-4-yl)-phenyl)-piperidine
分子名称: 4-(4-CHLOROPHENYL)-4-[4-(1H-PYRAZOL-4-YL)PHENYL]PIPERIDINE, GLYCOGEN SYNTHASE KINASE-3 BETA, RAC-BETA SERINE/THREONINE-PROTEIN KINASE
著者Davies, T.G, Saxty, G, Woodhead, S.J, Berdini, V, Verdonk, M.L, Wyatt, P.G, Boyle, R.G, Barford, D, Downham, R, Garrett, M.D, Carr, R.A.
登録日2007-03-19
公開日2007-05-08
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Identification of Inhibitors of Protein Kinase B Using Fragment-Based Lead Discovery.
J.Med.Chem., 50, 2007
2UW8
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Structure of PKA-PKB chimera complexed with 2-(4-chloro-phenyl)-2- phenyl-ethylamine
分子名称: (2R)-2-(4-CHLOROPHENYL)-2-PHENYLETHANAMINE, CAMP-DEPENDENT PROTEIN KINASE INHIBITOR ALPHA, CAMP-DEPENDENT PROTEIN KINASE, ...
著者Davies, T.G, Saxty, G, Woodhead, S.J, Berdini, V, Verdonk, M.L, Wyatt, P.G, Boyle, R.G, Barford, D, Downham, R, Garrett, M.D, Carr, R.A.
登録日2007-03-19
公開日2007-05-08
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Identification of Inhibitors of Protein Kinase B Using Fragment-Based Lead Discovery.
J.Med.Chem., 50, 2007
2UW3
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Structure of PKA-PKB chimera complexed with 5-methyl-4-phenyl-1H- pyrazole
分子名称: 3-METHYL-4-PHENYL-1H-PYRAZOLE, CAMP-DEPENDENT PROTEIN KINASE INHIBITOR ALPHA, CAMP-DEPENDENT PROTEIN KINASE, ...
著者Davies, T.G, Saxty, G, Woodhead, S.J, Berdini, V, Verdonk, M.L, Wyatt, P.G, Boyle, R.G, Barford, D, Downham, R, Garrett, M.D, Carr, R.A.
登録日2007-03-19
公開日2007-05-08
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.19 Å)
主引用文献Identification of Inhibitors of Protein Kinase B Using Fragment-Based Lead Discovery
J.Med.Chem., 50, 2007
2VFL
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AKAP18 delta central domain - CMP
分子名称: AKAP18 DELTA, CYTIDINE-5'-MONOPHOSPHATE
著者Gold, M.G, Smith, F.D, Scott, J.D, Barford, D.
登録日2007-11-05
公開日2008-05-06
最終更新日2024-05-01
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献Akap18 Contains a Phosphoesterase Domain that Binds AMP
J.Mol.Biol., 375, 2008
2VFK
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AKAP18 delta central domain - AMP
分子名称: ADENOSINE MONOPHOSPHATE, AKAP18 DELTA
著者Gold, M.G, Smith, F.D, Scott, J.D, Barford, D.
登録日2007-11-05
公開日2008-05-06
最終更新日2024-05-01
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Akap18 Contains a Phosphoesterase Domain that Binds AMP
J.Mol.Biol., 375, 2008
2IXM
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Structure of human PTPA
分子名称: SERINE/THREONINE-PROTEIN PHOSPHATASE 2A REGULATORY SUBUNIT B'
著者Leulliot, N, Vicentini, G, Jordens, J, Quevillon-Cheruel, S, Schiltz, M, Barford, D, Van Tilbeurgh, H, Goris, J.
登録日2006-07-09
公開日2006-07-11
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Crystal Structure of the Pp2A Phosphatase Activator: Implications for its Pp2A-Specific Ppiase Activity
Mol.Cell, 23, 2006
2IXN
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CRYSTAL STRUCTURE OF THE PP2A PHOSPHATASE ACTIVATOR Ypa2 PTPA2
分子名称: SERINE/THREONINE-PROTEIN PHOSPHATASE 2A ACTIVATOR 2
著者Leulliot, N, Vicentini, G, Jordens, J, Quevillon-Cheruel, S, Schiltz, M, Barford, D, Van Tilbeurgh, H, Goris, J.
登録日2006-07-09
公開日2006-07-31
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Crystal Structure of the Pp2A Phosphatase Activator: Implications for its Pp2A-Specific Ppiase Activity
Mol.Cell, 23, 2006
2WMN
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Structure of the complex between DOCK9 and Cdc42-GDP.
分子名称: CELL DIVISION CONTROL PROTEIN 42 HOMOLOG, DEDICATOR OF CYTOKINESIS PROTEIN 9, GUANOSINE-5'-DIPHOSPHATE
著者Yang, J, Roe, S.M, Barford, D.
登録日2009-07-02
公開日2009-09-22
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.391 Å)
主引用文献Activation of Rho Gtpases by Dock Exchange Factors is Mediated by a Nucleotide Sensor.
Science, 325, 2009

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