2VSZ

Crystal Structure of the ELMO1 PH domain

Summary for 2VSZ

Entry DOI	10.2210/pdb2vsz/pdb
Descriptor	ENGULFMENT AND CELL MOTILITY PROTEIN 1 (2 entities in total)
Functional Keywords	apoptosis, rac signalling, sh3-binding, phagocytosis, elmo, dock180, phosphoinositide binding, guanine nucleotide exchange factor
Biological source	HOMO SAPIENS (HUMAN)
Cellular location	Cytoplasm: Q92556
Total number of polymer chains	2
Total formula weight	34205.50
Authors	Komander, D.,Patel, M.,Barford, D.,Cote, J.-F. (deposition date: 2008-05-01, release date: 2009-03-10, Last modification date: 2024-05-08)
Primary citation	Komander, D.,Patel, M.,Laurin, M.,Fradet, N.,Pelletier, A.,Barford, D.,Cote, J.-F. An Alpha-Helical Extension of the Elmo1 Pleckstrin Homology Domain Mediates Direct Interaction to Dock180 and is Critical in Rac Signaling. Molecular Biology of the Cell, 19:4837-, 2008 Cited by PubMed: 18768751 DOI: 10.1091/MBC.E08-04-0345 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation