1JMY
| Truncated Recombinant Human Bile Salt Stimulated Lipase | Descriptor: | BILE-SALT-ACTIVATED LIPASE, SULFATE ION | Authors: | Moore, S.A, Kingston, R.L, Loomes, K.M, Hernell, O, Blackberg, L, Baker, H.M, Baker, E.N. | Deposit date: | 2001-07-20 | Release date: | 2001-08-08 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | The structure of truncated recombinant human bile salt-stimulated lipase reveals bile salt-independent conformational flexibility at the active-site loop and provides insights into heparin binding. J.Mol.Biol., 312, 2001
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1H6D
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4ZOK
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1DSN
| D60S N-TERMINAL LOBE HUMAN LACTOFERRIN | Descriptor: | CARBONATE ION, FE (III) ION, LACTOFERRIN | Authors: | Faber, H.R, Norris, G.E, Baker, E.N. | Deposit date: | 1995-12-13 | Release date: | 1996-03-08 | Last modified: | 2021-11-03 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Altered domain closure and iron binding in transferrins: the crystal structure of the Asp60Ser mutant of the amino-terminal half-molecule of human lactoferrin. J.Mol.Biol., 256, 1996
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1HSE
| H253M N TERMINAL LOBE OF HUMAN LACTOFERRIN | Descriptor: | CARBONATE ION, FE (III) ION, LACTOFERRIN | Authors: | Nicholson, H, Anderson, B.F, Baker, E.N. | Deposit date: | 1996-12-11 | Release date: | 1997-03-12 | Last modified: | 2021-11-03 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Mutagenesis of the histidine ligand in human lactoferrin: iron binding properties and crystal structure of the histidine-253-->methionine mutant. Biochemistry, 36, 1997
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2YPO
| 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase with phenylalanine bound in only one site | Descriptor: | GLYCEROL, MANGANESE (II) ION, PHENYLALANINE, ... | Authors: | Blackmore, N.J, Reichau, S, Jiao, W, Hutton, R.D, Baker, E.N, Jameson, G.B, Parker, E.J. | Deposit date: | 2012-10-31 | Release date: | 2013-01-09 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Three Sites and You are Out: Ternary Synergistic Allostery Controls Aromatic Aminoacid Biosynthesis in Mycobacterium Tuberculosis. J.Mol.Biol., 425, 2013
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3CEV
| ARGINASE FROM BACILLUS CALDEVELOX, COMPLEXED WITH L-ARGININE | Descriptor: | ARGININE, MANGANESE (II) ION, PROTEIN (ARGINASE) | Authors: | Bewley, M.C, Jeffrey, P.D, Patchett, M.L, Kanyo, Z.F, Baker, E.N. | Deposit date: | 1999-03-15 | Release date: | 1999-04-16 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Crystal structures of Bacillus caldovelox arginase in complex with substrate and inhibitors reveal new insights into activation, inhibition and catalysis in the arginase superfamily. Structure Fold.Des., 7, 1999
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5E5Q
| Racemic snakin-1 in P21/c | Descriptor: | Snakin-1 | Authors: | Yeung, H, Squire, C.J, Yosaatmadja, Y, Panjikar, S, Baker, E.N, Harris, P.W.R, Brimble, M.A. | Deposit date: | 2015-10-09 | Release date: | 2016-05-18 | Last modified: | 2016-07-20 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Radiation Damage and Racemic Protein Crystallography Reveal the Unique Structure of the GASA/Snakin Protein Superfamily. Angew.Chem.Int.Ed.Engl., 55, 2016
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6UCD
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5UA2
| Mycobacterium tuberculosis KstR in complex with a 26-bp DNA operator | Descriptor: | DNA (5'-D(P*AP*CP*TP*AP*TP*TP*AP*GP*AP*AP*CP*AP*CP*GP*TP*TP*CP*TP*AP*GP*TP*GP*GP*G)-3'), DNA (5'-D(P*CP*CP*CP*AP*CP*TP*AP*GP*AP*AP*CP*GP*TP*GP*TP*TP*CP*TP*AP*AP*TP*AP*GP*T)-3'), HTH-type transcriptional repressor KstR, ... | Authors: | Ho, N.A.T, Dawes, S.S, Baker, E.N, Lott, J.S, TB Structural Genomics Consortium (TBSGC) | Deposit date: | 2016-12-18 | Release date: | 2017-12-20 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.9002 Å) | Cite: | Crystal structure of KstR in complex with cognate DNA operator To Be Published
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5TTD
| Minor pilin FctB from S. pyogenes with engineered intramolecular isopeptide bond | Descriptor: | FORMIC ACID, Maltose-binding periplasmic protein,Pilin isopeptide linkage domain protein, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose | Authors: | Young, P.G, Kwon, H, Squire, C.J, Baker, E.N. | Deposit date: | 2016-11-02 | Release date: | 2017-03-01 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Engineering a Lys-Asn isopeptide bond into an immunoglobulin-like protein domain enhances its stability. Sci Rep, 7, 2017
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2CEV
| ARGINASE FROM BACILLUS CALDEVELOX, NATIVE STRUCTURE AT PH 8.5 | Descriptor: | GUANIDINE, MANGANESE (II) ION, PROTEIN (ARGINASE) | Authors: | Bewley, M.C, Jeffrey, P.D, Patchett, M.L, Kanyo, Z.F, Baker, E.N. | Deposit date: | 1999-03-10 | Release date: | 1999-04-16 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | Crystal structures of Bacillus caldovelox arginase in complex with substrate and inhibitors reveal new insights into activation, inhibition and catalysis in the arginase superfamily. Structure Fold.Des., 7, 1999
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2BPQ
| Anthranilate phosphoribosyltransferase (TrpD) from Mycobacterium tuberculosis (Apo structure) | Descriptor: | ANTHRANILATE PHOSPHORIBOSYLTRANSFERASE, BENZAMIDINE, GLYCEROL | Authors: | Lee, C.E, Goodfellow, C, Javid-Majd, F, Baker, E.N, Lott, J.S, TB Structural Genomics Consortium (TBSGC) | Deposit date: | 2005-04-22 | Release date: | 2006-01-04 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | The Crystal Structure of Trpd, a Metabolic Enzyme Essential for Lung Colonization by Mycobacterium Tuberculosis, in Complex with its Substrate Phosphoribosylpyrophosphate J.Mol.Biol., 355, 2006
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1V8P
| Crystal structure of PAE2754 from Pyrobaculum aerophilum | Descriptor: | CHLORIDE ION, hypothetical protein PAE2754 | Authors: | Arcus, V.L, Backbro, K, Roos, A, Daniel, E.L, Baker, E.N. | Deposit date: | 2004-01-12 | Release date: | 2004-02-10 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.52 Å) | Cite: | Distant structural homology leads to the functional characterization of an archaeal PIN domain as an exonuclease J.Biol.Chem., 279, 2004
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1V8O
| Crystal Structure of PAE2754 from Pyrobaculum aerophilum | Descriptor: | CHLORIDE ION, hypothetical protein PAE2754 | Authors: | Arcus, V.L, Backbro, K, Roos, A, Daniel, E.L, Baker, E.N. | Deposit date: | 2004-01-12 | Release date: | 2004-02-10 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Distant structural homology leads to the functional characterization of an archaeal PIN domain as an exonuclease J.Biol.Chem., 279, 2004
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5V00
| Structure of HutD from Pseudomonas fluorescens SBW25 (Formate condition) | Descriptor: | FORMIC ACID, GLYCEROL, Uncharacterized protein | Authors: | Liu, Y, Johnston, J.M, Gerth, M.L, Baker, E.N, Lott, J.S, Rainey, P.B. | Deposit date: | 2017-02-27 | Release date: | 2017-03-15 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Crystal structure of a bicupin protein HutD involved in histidine utilization in Pseudomonas. Proteins, 85, 2017
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3CQE
| Wee1 kinase complex with inhibitor PD074291 | Descriptor: | 8-bromo-4-(2-chlorophenyl)-N-(2-hydroxyethyl)-6-methyl-1,3-dioxo-1,2,3,6-tetrahydropyrrolo[3,4-e]indole-7-carboxamide, CHLORIDE ION, GLYCEROL, ... | Authors: | Squire, C.J, Baker, E.N. | Deposit date: | 2008-04-02 | Release date: | 2009-02-24 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structural Determinants of Wee1 Inhibitor Selectivity To be Published
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3CR0
| Wee1 kinase complex with inhibitor PD259_809 | Descriptor: | 4-(2-chlorophenyl)-8-(2-hydroxyethyl)-6-methylpyrrolo[3,4-e]indole-1,3(2H,6H)-dione, CHLORIDE ION, GLYCEROL, ... | Authors: | Squire, C.J, Baker, E.N. | Deposit date: | 2008-04-03 | Release date: | 2009-02-24 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structural determinants of Wee1 inhibitor selectivity To be Published
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1ET9
| CRYSTAL STRUCTURE OF THE SUPERANTIGEN SPE-H FROM STREPTOCOCCUS PYOGENES | Descriptor: | SUPERANTIGEN SPE-H | Authors: | Arcus, V.L, Proft, T, Sigrell, J.A, Baker, H.M, Fraser, J.D, Baker, E.N. | Deposit date: | 2000-04-12 | Release date: | 2000-04-26 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Conservation and variation in superantigen structure and activity highlighted by the three-dimensional structures of two new superantigens from Streptococcus pyogenes. J.Mol.Biol., 299, 2000
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3DCJ
| Crystal structure of glycinamide formyltransferase (PurN) from Mycobacterium tuberculosis in complex with 5-methyl-5,6,7,8-tetrahydrofolic acid derivative | Descriptor: | CHLORIDE ION, MAGNESIUM ION, N-[4-({[(6S)-2-AMINO-4-HYDROXY-5-METHYL-5,6,7,8-TETRAHYDROPTERIDIN-6-YL]METHYL}AMINO)BENZOYL]-L-GLUTAMIC ACID, ... | Authors: | Zhang, Z, Squire, C.J, Baker, E.N. | Deposit date: | 2008-06-03 | Release date: | 2009-05-12 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structures of glycinamide ribonucleotide transformylase (PurN) from Mycobacterium tuberculosis reveal a novel dimer with relevance to drug discovery. J.Mol.Biol., 389, 2009
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1F5J
| CRYSTAL STRUCTURE OF XYNB, A HIGHLY THERMOSTABLE BETA-1,4-XYLANASE FROM DICTYOGLOMUS THERMOPHILUM RT46B.1, AT 1.8 A RESOLUTION | Descriptor: | BETA-1,4-XYLANASE, SULFATE ION | Authors: | McCarthy, A.A, Baker, E.N. | Deposit date: | 2000-07-26 | Release date: | 2000-11-15 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structure of XynB, a highly thermostable beta-1,4-xylanase from Dictyoglomus thermophilum Rt46B.1, at 1.8 A resolution. Acta Crystallogr.,Sect.D, 56, 2000
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4WVH
| Crystal structure of the Type-I signal peptidase from Staphylococcus aureus (SpsB) in complex with a substrate peptide (pep1). | Descriptor: | Maltose-binding periplasmic protein,Signal peptidase IB, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose, substrate peptide (pep1) | Authors: | Young, P.G, Ting, Y.T, Baker, E.N. | Deposit date: | 2014-11-05 | Release date: | 2015-09-23 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Peptide binding to a bacterial signal peptidase visualized by peptide tethering and carrier-driven crystallization. IUCrJ, 3, 2016
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4WVG
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4WSP
| Racemic crystal structure of Rv1738 from Mycobacterium tuberculosis (Form-I) | Descriptor: | CHLORIDE ION, protein DL-Rv1738 | Authors: | Bunker, R.D, Mandal, K, Kent, S.B.H, Baker, E.N. | Deposit date: | 2014-10-28 | Release date: | 2015-03-18 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | A functional role of Rv1738 in Mycobacterium tuberculosis persistence suggested by racemic protein crystallography. Proc.Natl.Acad.Sci.USA, 112, 2015
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1H6B
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