3L0R
| Crystal Structure of Salivary Cystatin from the Soft Tick Ornithodoros moubata | 分子名称: | CHLORIDE ION, Cystatin-2, GLYCEROL | 著者 | Rezacova, P, Brynda, J, Andersen, J.F, Salat, J, Kovarova, Z, Mares, M. | 登録日 | 2009-12-10 | 公開日 | 2010-06-30 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.45 Å) | 主引用文献 | Crystal structure and functional characterization of an immunomodulatory salivary cystatin from the soft tick Ornithodoros moubata Biochem.J., 429, 2010
|
|
1UMY
| BHMT from rat liver | 分子名称: | BETA-MERCAPTOETHANOL, Betaine--homocysteine S-methyltransferase 1, ZINC ION | 著者 | Gonzalez, B, Pajares, M.A, Sanz-Aparicio, J. | 登録日 | 2003-09-02 | 公開日 | 2004-05-06 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Crystal structure of rat liver betaine homocysteine s-methyltransferase reveals new oligomerization features and conformational changes upon substrate binding. J. Mol. Biol., 338, 2004
|
|
3NDA
| Crystal structure of serpin from tick Ixodes ricinus | 分子名称: | PENTAETHYLENE GLYCOL, Serpin-2 | 著者 | Rezacova, P, Kovarova, Z, Chmelar, J, Mares, M. | 登録日 | 2010-06-07 | 公開日 | 2010-10-27 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | A tick salivary protein targets cathepsin G and chymase and inhibits host inflammation and platelet aggregation. Blood, 117, 2011
|
|
3QSD
| Structure of cathepsin B1 from Schistosoma mansoni in complex with CA074 inhibitor | 分子名称: | ACETATE ION, Cathepsin B-like peptidase (C01 family), DI(HYDROXYETHYL)ETHER, ... | 著者 | Rezacova, P, Jilkova, A, Brynda, J, Horn, M, Mares, M. | 登録日 | 2011-02-21 | 公開日 | 2011-08-10 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | 主引用文献 | Structural Basis for Inhibition of Cathepsin B Drug Target from the Human Blood Fluke, Schistosoma mansoni. J.Biol.Chem., 286, 2011
|
|
3A59
| |
4I04
| Structure of zymogen of cathepsin B1 from Schistosoma mansoni | 分子名称: | 1,2-ETHANEDIOL, Cathepsin B-like peptidase (C01 family) | 著者 | Rezacova, P, Jilkova, A, Brynda, J, Horn, M, Mares, M. | 登録日 | 2012-11-16 | 公開日 | 2014-02-05 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Activation route of the Schistosoma mansoni cathepsin B1 drug target: structural map with a glycosaminoglycan switch Structure, 22, 2014
|
|
3S3Q
| Structure of cathepsin B1 from Schistosoma mansoni in complex with K11017 inhibitor | 分子名称: | ACETATE ION, Cathepsin B-like peptidase (C01 family), N~2~-(morpholin-4-ylcarbonyl)-N-[(3S)-1-phenyl-5-(phenylsulfonyl)pentan-3-yl]-L-leucinamide | 著者 | Rezacova, P, Jilkova, A, Brynda, J, Horn, M, Mares, M. | 登録日 | 2011-05-18 | 公開日 | 2011-08-10 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Structural Basis for Inhibition of Cathepsin B Drug Target from the Human Blood Fluke, Schistosoma mansoni. J.Biol.Chem., 286, 2011
|
|
3S3R
| Structure of cathepsin B1 from Schistosoma mansoni in complex with K11777 inhibitor | 分子名称: | Cathepsin B-like peptidase (C01 family), Nalpha-[(4-methylpiperazin-1-yl)carbonyl]-N-[(3S)-1-phenyl-5-(phenylsulfonyl)pentan-3-yl]-L-phenylalaninamide | 著者 | Rezacova, P, Jilkova, A, Brynda, J, Horn, M, Mares, M. | 登録日 | 2011-05-18 | 公開日 | 2011-08-10 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.64 Å) | 主引用文献 | Structural Basis for Inhibition of Cathepsin B Drug Target from the Human Blood Fluke, Schistosoma mansoni. J.Biol.Chem., 286, 2011
|
|
1GV7
| ARH-I, an angiogenin/RNase A chimera | 分子名称: | ANGIOGENIN, CITRIC ACID | 著者 | Holloway, D.E, Shapiro, R, Hares, M.C, Leonidas, D.D, Acharya, K.R. | 登録日 | 2002-02-06 | 公開日 | 2002-08-22 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Guest-Host Crosstalk in an Angiogenin-RNase A Chimeric Protein Biochemistry, 41, 2002
|
|
2ZFB
| |
5FOE
| Crystal structure of the C. elegans Protein O-fucosyltransferase 2 (CePOFUT2) double mutant (R298K-R299K) in complex with GDP and the human TSR1 from thrombospondin 1 | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, GDP-fucose protein O-fucosyltransferase 2,Thrombospondin-1, ... | 著者 | Valero-Gonzalez, J, Leonhard-Melief, C, Lira-Navarrete, E, Jimenez-Oses, G, Hernandez-Ruiz, C, Pallares, M.C, Yruela, I, Vasudevan, D, Lostao, A, Corzana, F, Takeuchi, H, Haltiwanger, R.S, Hurtado-Guerrero, R. | 登録日 | 2015-11-19 | 公開日 | 2016-01-27 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.98 Å) | 主引用文献 | A Proactive Role of Water Molecules in Acceptor Recognition of Thrombospondin Type 1 Repeats by Protein-O-Fucosyltransferase 2 Nat.Chem.Biol., 12, 2016
|
|
2ZP6
| |
4I05
| Structure of intermediate processing form of cathepsin B1 from Schistosoma mansoni | 分子名称: | Cathepsin B-like peptidase (C01 family), SODIUM ION | 著者 | Rezacova, P, Jilkova, A, Brynda, J, Horn, M, Mares, M. | 登録日 | 2012-11-16 | 公開日 | 2014-02-05 | 最終更新日 | 2023-12-06 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Activation route of the Schistosoma mansoni cathepsin B1 drug target: structural map with a glycosaminoglycan switch Structure, 22, 2014
|
|
1O90
| Methionine Adenosyltransferase complexed with a L-methionine analogue | 分子名称: | (2S,4S)-2-AMINO-4,5-EPOXIPENTANOIC ACID, MAGNESIUM ION, PHOSPHATE ION, ... | 著者 | Gonzalez, B, Pajares, M.A, Hermoso, J.A, Sanz-Aparicio, J. | 登録日 | 2002-12-10 | 公開日 | 2003-08-07 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | 主引用文献 | Crystal Structures of Methionine Adenosyltransferase Complexed with Substrates and Products Reveal the Methionine-ATP Recognition and Give Insights Into the Catalytic Mechanism J.Mol.Biol., 331, 2003
|
|
1O92
| Methionine Adenosyltransferase complexed with ADP and a L-methionine analogue | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, L-2-AMINO-4-METHOXY-CIS-BUT-3-ENOIC ACID, MAGNESIUM ION, ... | 著者 | Gonzalez, B, Pajares, M.A, Hermoso, J.A, Sanz-Aparicio, J. | 登録日 | 2002-12-10 | 公開日 | 2003-08-07 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (3.19 Å) | 主引用文献 | Crystal Structures of Methionine Adenosyltransferase Complexed with Substrates and Products Reveal the Methionine-ATP Recognition and Give Insights Into the Catalytic Mechanism J.Mol.Biol., 331, 2003
|
|
1O9T
| Methionine adenosyltransferase complexed with both substrates ATP and methionine | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, METHIONINE, ... | 著者 | Gonzalez, B, Pajares, M.A, Hermoso, J.A, Sanz-Aparicio, J. | 登録日 | 2002-12-18 | 公開日 | 2003-08-07 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Crystal Structures of Methionine Adenosyltransferase Complexed with Substrates and Products Reveal the Methionine-ATP Recognition and Give Insights Into the Catalytic Mechanism J.Mol.Biol., 331, 2003
|
|
1O93
| Methionine Adenosyltransferase complexed with ATP and a L-methionine analogue | 分子名称: | (2S,4S)-2-AMINO-4,5-EPOXIPENTANOIC ACID, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | 著者 | Gonzalez, B, Pajares, M.A, Hermoso, J.A, Sanz-Aparicio, J. | 登録日 | 2002-12-10 | 公開日 | 2003-08-07 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (3.49 Å) | 主引用文献 | Crystal Structures of Methionine Adenosyltransferase Complexed with Substrates and Products Reveal the Methionine-ATP Recognition and Give Insights Into the Catalytic Mechanism J.Mol.Biol., 331, 2003
|
|
4I07
| Structure of mature form of cathepsin B1 from Schistosoma mansoni | 分子名称: | ACETATE ION, CHLORIDE ION, Cathepsin B-like peptidase (C01 family) | 著者 | Rezacova, P, Jilkova, A, Brynda, J, Horn, M, Mares, M. | 登録日 | 2012-11-16 | 公開日 | 2014-02-05 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | 主引用文献 | Activation route of the Schistosoma mansoni cathepsin B1 drug target: structural map with a glycosaminoglycan switch Structure, 22, 2014
|
|
1QM4
| Methionine Adenosyltransferase Complexed with a L-Methionine Analogue | 分子名称: | L-2-AMINO-4-METHOXY-CIS-BUT-3-ENOIC ACID, MAGNESIUM ION, METHIONINE ADENOSYLTRANSFERASE, ... | 著者 | Gonzalez, B, Pajares, M.A, Hermoso, J.A, Sanz-Aparicio, J. | 登録日 | 1999-09-20 | 公開日 | 2000-09-21 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.66 Å) | 主引用文献 | The Crystal Structure of Tetrameric Methionine Adenosyltransferase from Rat Liver Reveals the Methionine-Binding Site J.Mol.Biol., 300, 2000
|
|
4K7W
| Crystal structure of Zn3-hUb(human ubiquitin) adduct from a solution 100 mM zinc acetate/1.3 mM hUb | 分子名称: | 1,2-ETHANEDIOL, ACETATE ION, ZINC ION, ... | 著者 | Fermani, S, Falini, G, Calvaresi, M, Bottoni, A, Arnesano, F, Natile, G. | 登録日 | 2013-04-17 | 公開日 | 2013-05-08 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.76 Å) | 主引用文献 | Conformational selection of ubiquitin quaternary structures driven by zinc ions. Chemistry, 19, 2013
|
|
4K7U
| Crystal structure of Zn2.3-hUb (human ubiquitin) adduct from a solution 70 mM zinc acetate/1.3 mM hUb | 分子名称: | 1,2-ETHANEDIOL, ACETATE ION, DI(HYDROXYETHYL)ETHER, ... | 著者 | Fermani, S, Falini, G, Calvaresi, M, Bottoni, A, Arnesano, F, Natile, G. | 登録日 | 2013-04-17 | 公開日 | 2013-05-08 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.76 Å) | 主引用文献 | Conformational selection of ubiquitin quaternary structures driven by zinc ions. Chemistry, 19, 2013
|
|
4K7S
| Crystal structure of Zn2-hUb (human ubiquitin) adduct from a solution 35 mM zinc acetate/1.3 mM hUb | 分子名称: | 1,2-ETHANEDIOL, ACETATE ION, ZINC ION, ... | 著者 | Fermani, S, Falini, G, Calvaresi, M, Bottoni, A, Arnesano, F, Natile, G. | 登録日 | 2013-04-17 | 公開日 | 2013-05-08 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.76 Å) | 主引用文献 | Conformational selection of ubiquitin quaternary structures driven by zinc ions. Chemistry, 19, 2013
|
|
2BWL
| Murine angiogenin, phosphate complex | 分子名称: | ANGIOGENIN, PHOSPHATE ION | 著者 | Holloway, D.E, Chavali, G.B, Hares, M.C, Subramanian, V, Acharya, K.R. | 登録日 | 2005-07-15 | 公開日 | 2005-11-30 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (1.62 Å) | 主引用文献 | Structure of Murine Angiogenin: Features of the Substrate- and Cell-Binding Regions and Prospects for Inhibitor-Binding Studies. Acta Crystallogr.,Sect.D, 61, 2005
|
|
2BWK
| Murine angiogenin, sulphate complex | 分子名称: | ANGIOGENIN, SULFATE ION | 著者 | Holloway, D.E, Chavali, G.B, Hares, M.C, Subramanian, V, Acharya, K.R. | 登録日 | 2005-07-15 | 公開日 | 2005-11-30 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Structure of Murine Angiogenin: Features of the Substrate- and Cell-Binding Regions and Prospects for Inhibitor-Binding Studies. Acta Crystallogr.,Sect.D, 61, 2005
|
|
5OGR
| Structure of cathepsin B1 from Schistosoma mansoni in complex with WRR286 inhibitor | 分子名称: | 3-[[N-[4-METHYL-PIPERAZINYL]CARBONYL]-PHENYLALANINYL-AMINO]-5-PHENYL-PENTANE-1-SULFONIC ACID BENZYLOXY-AMIDE, ACETATE ION, Cathepsin B-like peptidase (C01 family) | 著者 | Jilkova, A, Rezacova, P, Brynda, J, Mares, M. | 登録日 | 2017-07-13 | 公開日 | 2018-11-21 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | 主引用文献 | Druggable Hot Spots in the Schistosomiasis Cathepsin B1 Target Identified by Functional and Binding Mode Analysis of Potent Vinyl Sulfone Inhibitors. Acs Infect Dis., 2020
|
|