5FOE
Crystal structure of the C. elegans Protein O-fucosyltransferase 2 (CePOFUT2) double mutant (R298K-R299K) in complex with GDP and the human TSR1 from thrombospondin 1
Summary for 5FOE
| Entry DOI | 10.2210/pdb5foe/pdb |
| Descriptor | GDP-fucose protein O-fucosyltransferase 2,Thrombospondin-1, 2-acetamido-2-deoxy-beta-D-glucopyranose, GUANOSINE-5'-DIPHOSPHATE, ... (5 entities in total) |
| Functional Keywords | transferase, pofut2, waters, fusion protein, afm, itc, glycosyltransferase, site-directed mutagenesis, molecular dynamics, tsr1 |
| Biological source | Caenorhabditis elegans More |
| Total number of polymer chains | 2 |
| Total formula weight | 116979.95 |
| Authors | Valero-Gonzalez, J.,Leonhard-Melief, C.,Lira-Navarrete, E.,Jimenez-Oses, G.,Hernandez-Ruiz, C.,Pallares, M.C.,Yruela, I.,Vasudevan, D.,Lostao, A.,Corzana, F.,Takeuchi, H.,Haltiwanger, R.S.,Hurtado-Guerrero, R. (deposition date: 2015-11-19, release date: 2016-01-27, Last modification date: 2024-01-10) |
| Primary citation | Valero-Gonzalez, J.,Leonhard-Melief, C.,Lira-Navarrete, E.,Jimenez-Oses, G.,Hernandez-Ruiz, C.,Pallares, M.C.,Yruela, I.,Vasudevan, D.,Lostao, A.,Corzana, F.,Takeuchi, H.,Haltiwanger, R.S.,Hurtado-Guerrero, R. A Proactive Role of Water Molecules in Acceptor Recognition of Thrombospondin Type 1 Repeats by Protein-O-Fucosyltransferase 2 Nat.Chem.Biol., 12:240-, 2016 Cited by PubMed: 26854667DOI: 10.1038/NCHEMBIO.2019 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.98 Å) |
Structure validation
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