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PDB: 396 results

3BT7
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BU of 3bt7 by Molmil
Structure of E. coli 5-Methyluridine Methyltransferase TrmA in complex with 19 nucleotide T-arm analogue
Descriptor: RNA (5'-D(P*GP*CP*UP*GP*UP*GP*(5MU)P*UP*CP*GP*AP*UP*CP*CP*AP*CP*AP*GP*C)-3'), tRNA (uracil-5-)-methyltransferase
Authors:Alian, A, Stroud, R.M, Finer-Moore, J.
Deposit date:2007-12-27
Release date:2008-04-29
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.43 Å)
Cite:Structure of a TrmA-RNA complex: A consensus RNA fold contributes to substrate selectivity and catalysis in m5U methyltransferases.
Proc.Natl.Acad.Sci.Usa, 105, 2008
4Z7I
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Crystal structure of insulin regulated aminopeptidase in complex with ligand
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, DG025 transition-state analogue enzyme inhibitor, ...
Authors:Mpakali, A, Saridakis, E, Harlos, K, Zhao, Y, Stratikos, E.
Deposit date:2015-04-07
Release date:2015-08-26
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (3.31 Å)
Cite:Crystal Structure of Insulin-Regulated Aminopeptidase with Bound Substrate Analogue Provides Insight on Antigenic Epitope Precursor Recognition and Processing.
J Immunol., 195, 2015
5MJ6
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Ligand-induced conformational change of Insulin-regulated aminopeptidase: insights on catalytic mechanism and active site plasticity.
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, BROMIDE ION, ...
Authors:Mpakali, A, Stratikos, E, Saridakis, E, Giastas, P.
Deposit date:2016-11-30
Release date:2017-04-05
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.53 Å)
Cite:Ligand-Induced Conformational Change of Insulin-Regulated Aminopeptidase: Insights on Catalytic Mechanism and Active Site Plasticity.
J. Med. Chem., 60, 2017
5AB2
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BU of 5ab2 by Molmil
Crystal structure of aminopeptidase ERAP2 with ligand
Descriptor: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Mpakali, A, Giastas, P, Saridakis, E, Mavridis, I.M, Stratikos, E.
Deposit date:2015-07-31
Release date:2015-09-30
Last modified:2024-10-09
Method:X-RAY DIFFRACTION (2.729 Å)
Cite:Structural Basis for Antigenic Peptide Recognition and Processing by Endoplasmic Reticulum (Er) Aminopeptidase 2.
J.Biol.Chem., 290, 2015
5AB0
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Crystal structure of aminopeptidase ERAP2 with ligand
Descriptor: 1,2-ETHANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Mpakali, A, Giastas, P, Saridakis, E, Stratikos, E.
Deposit date:2015-07-31
Release date:2015-09-30
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural Basis for Antigenic Peptide Recognition and Processing by Endoplasmic Reticulum (Er) Aminopeptidase 2.
J.Biol.Chem., 290, 2015
5LMK
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BU of 5lmk by Molmil
Structure of phopsho-CDK2-cyclin A in complex with an ATP-competitive inhibitor
Descriptor: 4-[4-[3-bromanyl-7-(pyridin-3-ylmethylamino)pyrazolo[1,5-a]pyrimidin-5-yl]phenyl]benzamide, Cyclin-A2, Cyclin-dependent kinase 2, ...
Authors:Echalier, A.
Deposit date:2016-08-01
Release date:2017-01-25
Last modified:2024-10-16
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Explicit treatment of active-site waters enhances quantum mechanical/implicit solvent scoring: Inhibition of CDK2 by new pyrazolo[1,5-a]pyrimidines.
Eur J Med Chem, 126, 2016
7ZYF
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BU of 7zyf by Molmil
Insulin regulated aminopeptidase (IRAP) in complex with a nanomolar alpha hydroxy beta amino acid based inhibitor.
Descriptor: 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Mpakali, A, Stratikos, E, Giastas, P, Papakyriakou, A.
Deposit date:2022-05-24
Release date:2022-07-20
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.81 Å)
Cite:Discovery of Selective Nanomolar Inhibitors for Insulin-Regulated Aminopeptidase Based on alpha-Hydroxy-beta-amino Acid Derivatives of Bestatin.
J.Med.Chem., 65, 2022
5ZEF
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BU of 5zef by Molmil
Crystal structure of Entamoeba histolytica Arginase in complex with L- Norvaline at 2.01 A
Descriptor: 1,2-ETHANEDIOL, Arginase, GLYCEROL, ...
Authors:Malik, A, Dalal, V, Ankri, S, Tomar, S.
Deposit date:2018-02-27
Release date:2019-06-26
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.01 Å)
Cite:Structural insights into Entamoeba histolytica arginase and structure-based identification of novel non-amino acid based inhibitors as potential antiamoebic molecules.
Febs J., 286, 2019
1BX0
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BU of 1bx0 by Molmil
Ferredoxin:nadp+ oxidoreductase (ferredoxin reductase) mutant e312l
Descriptor: FLAVIN-ADENINE DINUCLEOTIDE, PHOSPHATE ION, PROTEIN (FERREDOXIN:NADP+ OXIDOREDUCTASE), ...
Authors:Aliverti, A, Deng, Z, Ravasi, D, Piubelli, L, Karplus, P.A, Zanetti, G.
Deposit date:1998-10-10
Release date:1998-10-14
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Probing the function of the invariant glutamyl residue 312 in spinach ferredoxin-NADP+ reductase.
J.Biol.Chem., 273, 1998
1BX1
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BU of 1bx1 by Molmil
FERREDOXIN:NADP+ OXIDOREDUCTASE (FERREDOXIN REDUCTASE) MUTANT E312Q
Descriptor: FLAVIN-ADENINE DINUCLEOTIDE, PHOSPHATE ION, PROTEIN (FERREDOXIN:NADP+ OXIDOREDUCTASE), ...
Authors:Aliverti, A, Deng, Z, Ravasi, D, Piubelli, L, Karplus, P.A, Zanetti, G.
Deposit date:1998-10-10
Release date:1998-10-14
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Probing the function of the invariant glutamyl residue 312 in spinach ferredoxin-NADP+ reductase.
J.Biol.Chem., 273, 1998
5ZEH
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BU of 5zeh by Molmil
Crystal structure of Entamoeba histolytica Arginase in complex with L- Ornithine at 2.35 A
Descriptor: 1,2-ETHANEDIOL, Arginase, L-ornithine, ...
Authors:Malik, A, Dalal, V, Ankri, S, Tomar, S.
Deposit date:2018-02-27
Release date:2019-06-26
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (2.36 Å)
Cite:Structural insights into Entamoeba histolytica arginase and structure-based identification of novel non-amino acid based inhibitors as potential antiamoebic molecules.
Febs J., 286, 2019
5ZEE
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BU of 5zee by Molmil
Crystal structure of Entamoeba histolytica Arginase in complex with N(omega)-hydroxy-L-arginine (NOHA) at 1.74 A
Descriptor: 1,2-ETHANEDIOL, Arginase, MANGANESE (II) ION, ...
Authors:Malik, A, Dalal, V, Ankri, S, Tomar, S.
Deposit date:2018-02-27
Release date:2019-06-26
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.74 Å)
Cite:Structural insights into Entamoeba histolytica arginase and structure-based identification of novel non-amino acid based inhibitors as potential antiamoebic molecules.
Febs J., 286, 2019
5C97
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BU of 5c97 by Molmil
Insulin regulated aminopeptidase
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Leucyl-cystinyl aminopeptidase, ...
Authors:Mpakali, A, Saridakis, E, Harlos, K, Zhao, Y, Stratikos, E.
Deposit date:2015-06-26
Release date:2015-08-26
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (3.37 Å)
Cite:Crystal Structure of Insulin-Regulated Aminopeptidase with Bound Substrate Analogue Provides Insight on Antigenic Epitope Precursor Recognition and Processing.
J Immunol., 195, 2015
8P0I
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BU of 8p0i by Molmil
Crystal structure of the open conformation of insulin-regulated aminopeptidase in complex with a small-MW inhibitor
Descriptor: 2-[2-(3,5-dimethylpyrazol-1-yl)-6-(4-methoxyphenyl)pyrimidin-4-yl]oxy-N-methyl-N-[(2-methylpyridin-3-yl)methyl]ethanamide, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Mpakali, A, Giastas, P, Stratikos, E.
Deposit date:2023-05-10
Release date:2024-09-04
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Stabilization of the open conformation omicron f insulin-regulated aminopeptidase by a novel substrate-selective small-molecule inhibitor.
Protein Sci., 33, 2024
3DH3
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BU of 3dh3 by Molmil
Crystal Structure of RluF in complex with a 22 nucleotide RNA substrate
Descriptor: Ribosomal large subunit pseudouridine synthase F, stem loop fragment of E. Coli 23S RNA
Authors:Alian, A, DeGiovanni, A, Stroud, R.M, Finer-Moore, J.S.
Deposit date:2008-06-16
Release date:2009-04-28
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (3 Å)
Cite:Crystal structure of an RluF-RNA complex: a base-pair rearrangement is the key to selectivity of RluF for U2604 of the ribosome.
J.Mol.Biol., 388, 2009
5ER2
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BU of 5er2 by Molmil
High-resolution X-ray diffraction study of the complex between endothiapepsin and an oligopeptide inhibitor. the analysis of the inhibitor binding and description of the rigid body shift in the enzyme
Descriptor: 6-ammonio-N-{[(2R,3R)-3-{[N-(tert-butoxycarbonyl)-L-phenylalanyl-3-(1H-imidazol-3-ium-4-yl)-L-alanyl]amino}-4-cyclohexyl-2-hydroxybutyl](2-methylpropyl)carbamoyl}-L-norleucyl-L-phenylalanine, ENDOTHIAPEPSIN
Authors:Sali, A, Veerapandian, B, Cooper, J.B, Foundling, S.I, Hoover, D.J, Blundell, T.L.
Deposit date:1991-01-02
Release date:1991-04-15
Last modified:2024-10-09
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:High-resolution X-ray diffraction study of the complex between endothiapepsin and an oligopeptide inhibitor: the analysis of the inhibitor binding and description of the rigid body shift in the enzyme.
EMBO J., 8, 1989
4EOJ
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BU of 4eoj by Molmil
Thr 160 phosphorylated CDK2 H84S, Q85M, K89D - human cyclin A3 complex with ATP
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Cyclin-A2, Cyclin-dependent kinase 2, ...
Authors:Echalier, A, Cot, E, Camasses, A, Hodimont, E, Hoh, F, Sheinerman, F, Krasinska, L, Fisher, D.
Deposit date:2012-04-14
Release date:2013-02-06
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:An integrated chemical biology approach provides insight into Cdk2 functional redundancy and inhibitor sensitivity.
Chem.Biol., 19, 2012
4EOI
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Thr 160 phosphorylated CDK2 K89D, Q131E - human cyclin A3 complex with the inhibitor RO3306
Descriptor: (5E)-5-(quinolin-6-ylmethylidene)-2-[(thiophen-2-ylmethyl)amino]-1,3-thiazol-4(5H)-one, Cyclin-A2, Cyclin-dependent kinase 2, ...
Authors:Echalier, A, Cot, E, Camasses, A, Hodimont, E, Hoh, F, Sheinerman, F, Krasinska, L, Fisher, D.
Deposit date:2012-04-14
Release date:2013-02-06
Method:X-RAY DIFFRACTION (2 Å)
Cite:An integrated chemical biology approach provides insight into Cdk2 functional redundancy and inhibitor sensitivity.
Chem.Biol., 19, 2012
4EOP
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BU of 4eop by Molmil
Thr 160 phosphorylated CDK2 Q131E - human cyclin A3 complex with the inhibitor RO3306
Descriptor: (5E)-5-(quinolin-6-ylmethylidene)-2-[(thiophen-2-ylmethyl)amino]-1,3-thiazol-4(5H)-one, Cyclin-A2, Cyclin-dependent kinase 2, ...
Authors:Echalier, A, Cot, E, Camasses, A, Hodimont, E, Hoh, F, Sheinerman, F, Krasinska, L, Fisher, D.
Deposit date:2012-04-14
Release date:2013-02-06
Method:X-RAY DIFFRACTION (1.99 Å)
Cite:An integrated chemical biology approach provides insight into Cdk2 functional redundancy and inhibitor sensitivity.
Chem.Biol., 19, 2012
4EOM
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BU of 4eom by Molmil
Thr 160 phosphorylated CDK2 H84S, Q85M, Q131E - human cyclin A3 complex with ATP
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Cyclin-A2, Cyclin-dependent kinase 2, ...
Authors:Echalier, A, Cot, E, Camasses, A, Hodimont, E, Hoh, F, Sheinerman, F, Krasinska, L, Fisher, D.
Deposit date:2012-04-14
Release date:2013-02-06
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:An integrated chemical biology approach provides insight into Cdk2 functional redundancy and inhibitor sensitivity.
Chem.Biol., 19, 2012
4EOO
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BU of 4eoo by Molmil
Thr 160 phosphorylated CDK2 Q131E - human cyclin A3 complex with ATP
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Cyclin-A2, Cyclin-dependent kinase 2, ...
Authors:Echalier, A, Cot, E, Camasses, A, Hodimont, E, Hoh, F, Sheinerman, F, Krasinska, L, Fisher, D.
Deposit date:2012-04-14
Release date:2013-02-06
Last modified:2024-10-30
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:An integrated chemical biology approach provides insight into Cdk2 functional redundancy and inhibitor sensitivity.
Chem.Biol., 19, 2012
4EOK
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BU of 4eok by Molmil
Thr 160 phosphorylated CDK2 H84S, Q85M, K89D - human cyclin A3 complex with the inhibitor NU6102
Descriptor: Cyclin-A2, Cyclin-dependent kinase 2, MONOTHIOGLYCEROL, ...
Authors:Echalier, A, Cot, E, Camasses, A, Hodimont, E, Hoh, F, Sheinerman, F, Krasinska, L, Fisher, D.
Deposit date:2012-04-14
Release date:2013-02-06
Method:X-RAY DIFFRACTION (2.57 Å)
Cite:An integrated chemical biology approach provides insight into Cdk2 functional redundancy and inhibitor sensitivity.
Chem.Biol., 19, 2012
4EOS
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BU of 4eos by Molmil
Thr 160 phosphorylated CDK2 WT - human cyclin A3 complex with the inhibitor RO3306
Descriptor: (5E)-5-(quinolin-6-ylmethylidene)-2-[(thiophen-2-ylmethyl)amino]-1,3-thiazol-4(5H)-one, Cyclin-A2, Cyclin-dependent kinase 2
Authors:Echalier, A, Cot, E, Camasses, A, Hodimont, E, Hoh, F, Sheinerman, F, Krasinska, L, Fisher, D.
Deposit date:2012-04-14
Release date:2013-02-06
Last modified:2024-10-30
Method:X-RAY DIFFRACTION (2.57 Å)
Cite:An integrated chemical biology approach provides insight into Cdk2 functional redundancy and inhibitor sensitivity.
Chem.Biol., 19, 2012
5EE5
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BU of 5ee5 by Molmil
Structure of human ARL1 in complex with the DCB domain of BIG1
Descriptor: ACETATE ION, ADP-ribosylation factor-like protein 1, Brefeldin A-inhibited guanine nucleotide-exchange protein 1, ...
Authors:Galindo, A, Soler, N, Munro, S.
Deposit date:2015-10-22
Release date:2016-07-06
Last modified:2024-10-23
Method:X-RAY DIFFRACTION (2.279 Å)
Cite:Structural Insights into Arl1-Mediated Targeting of the Arf-GEF BIG1 to the trans-Golgi.
Cell Rep, 16, 2016
4EON
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BU of 4eon by Molmil
Thr 160 phosphorylated CDK2 H84S, Q85M, Q131E - human cyclin A3 complex with the inhibitor RO3306
Descriptor: (5E)-5-(quinolin-6-ylmethylidene)-2-[(thiophen-2-ylmethyl)amino]-1,3-thiazol-4(5H)-one, Cyclin-A2, Cyclin-dependent kinase 2, ...
Authors:Echalier, A, Cot, E, Camasses, A, Hodimont, E, Hoh, F, Sheinerman, F, Krasinska, L, Fisher, D.
Deposit date:2012-04-14
Release date:2013-02-06
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:An integrated chemical biology approach provides insight into Cdk2 functional redundancy and inhibitor sensitivity.
Chem.Biol., 19, 2012

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