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PDB: 64 件
5FUC
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Biophysical and cellular characterisation of a junctional epitope antibody that locks IL-6 and gp80 together in a stable complex: implications for new therapeutic strategies
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, INTERLEUKIN-6, INTERLEUKIN-6 RECEPTOR SUBUNIT ALPHA, ...
著者Adams, R, Griffin, R, Doyle, C, Ettorre, A.
登録日2016-01-25
公開日2017-01-25
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Discovery of a junctional epitope antibody that stabilizes IL-6 and gp80 protein:protein interaction and modulates its downstream signaling.
Sci Rep, 7, 2017
5FUO
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Extending the half-life of a Fab fragment through generation of a humanised anti-Human Serum Albumin (HSA) Fv domain: an investigation into the correlation between affinity and serum half-life
分子名称: FAB HEAVY CHAIN, FAB LIGHT CHAIN, SERUM ALBUMIN
著者Adams, R, Ceska, T.
登録日2016-01-28
公開日2016-06-29
最終更新日2024-10-23
実験手法X-RAY DIFFRACTION (3.6 Å)
主引用文献Extending the Half-Life of a Fab Fragment Through Generation of a Humanized Anti-Human Serum Albumin Fv Domain: An Investigation Into the Correlation between Affinity and Serum Half-Life.
Mabs, 8, 2016
5FUZ
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Extending the half-life of a Fab fragment through generation of a humanised anti-Human Serum Albumin (HSA) Fv domain: an investigation into the correlation between affinity and serum half-life
分子名称: 645 FAB, HEAVY CHAIN, LIGHT CHAIN
著者Adams, R, Ceska, T.
登録日2016-02-01
公開日2016-06-29
最終更新日2024-05-01
実験手法X-RAY DIFFRACTION (2.68 Å)
主引用文献Extending the Half-Life of a Fab Fragment Through Generation of a Humanized Anti-Human Serum Albumin Fv Domain: An Investigation Into the Correlation between Affinity and Serum Half-Life.
Mabs, 8, 2016
8RUU
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BU of 8ruu by Molmil
Fabs derived from bimekizumab in complex with IL-17F
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Immunoblobulin heavy chain, Immunoblobulin light chain, ...
著者Adams, R, Lawson, A.D.G.
登録日2024-01-31
公開日2024-04-24
最終更新日2024-10-23
実験手法X-RAY DIFFRACTION (2.81 Å)
主引用文献Crystal Structure of Bimekizumab Fab Fragment in Complex with IL-17F Provides Molecular Basis for Dual IL-17A and IL-17F Inhibition.
J Invest Dermatol., 2024
8C7J
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BU of 8c7j by Molmil
Phage display derived serum albumin binding knob domain engineered within a novel VH framework 3 bispecific antibody format
分子名称: CHLORIDE ION, Fab heavy chain with knob domain, Fab light chain
著者Adams, R, Macpherson, A.
登録日2023-01-16
公開日2023-06-07
最終更新日2024-10-16
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Serum albumin binding knob domains engineered within a V H framework III bispecific antibody format and as chimeric peptides.
Front Immunol, 14, 2023
8C7V
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Phage display derived serum albumin binding knob domain engineered within a novel VH framework 3 bispecific antibody format
分子名称: Fab heavy chain, Fab light chain
著者Adams, R, Macpherson, A.
登録日2023-01-17
公開日2023-06-07
実験手法X-RAY DIFFRACTION (1.61 Å)
主引用文献Serum albumin binding knob domains engineered within a V H framework III bispecific antibody format and as chimeric peptides.
Front Immunol, 14, 2023
5NLB
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BU of 5nlb by Molmil
Crystal structure of human CUL3 N-terminal domain bound to KEAP1 BTB and 3-box
分子名称: Cullin-3, Kelch-like ECH-associated protein 1
著者Adamson, R, Krojer, T, Pinkas, D.M, Bartual, S.G, Burgess-Brown, N.A, Borkowska, O, Chalk, R, Newman, J.A, Kopec, J, Dixon-Clarke, S.E, Mathea, S, Sethi, R, Velupillai, S, Mackinnon, S, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Bullock, A.
登録日2017-04-04
公開日2017-04-19
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (3.45 Å)
主引用文献Structural and biochemical characterization establishes a detailed understanding of KEAP1-CUL3 complex assembly.
Free Radic Biol Med, 204, 2023
6Z36
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BU of 6z36 by Molmil
Crystal structure of the ACVR1 (ALK2) kinase in complex with the compound M4K2118
分子名称: 1,2-ETHANEDIOL, 4-methyl-3-(4-piperidin-4-ylphenyl)-5-(3,4,5-trimethoxyphenyl)pyridine, AMMONIUM ION, ...
著者Adamson, R.J, Williams, E.P, Smil, D, Burgess-Brown, N, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Bullock, A.N.
登録日2020-05-19
公開日2020-05-27
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.37 Å)
主引用文献Crystal structure of the ACVR1 (ALK2) kinase in complex with the compound M4K2118
To Be Published
7A21
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Crystal structure of the ACVR1 (ALK2) kinase in complex with the compound M4K2158
分子名称: 1,2-ETHANEDIOL, 4-methyl-3-[4-(pyrrolidin-1-ylmethyl)phenyl]-5-(3,4,5-trimethoxyphenyl)pyridine, Activin receptor type I, ...
著者Adamson, R.J, Williams, E.P, Smil, D, Burgess-Brown, N, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Bullock, A.N.
登録日2020-08-14
公開日2020-09-16
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.14 Å)
主引用文献Crystal structure of the ACVR1 (ALK2) kinase in complex with the compound M4K2153
To Be Published
6T6D
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BU of 6t6d by Molmil
Crystal structure of the ACVR1 (ALK2) kinase in complex with the compound M4K2149
分子名称: 2-methoxy-4-[4-methyl-5-(4-piperazin-1-ylphenyl)pyridin-3-yl]benzamide, Activin receptor type I, SULFATE ION
著者Adamson, R.J, Williams, E.P, Smil, D, Burgess-Brown, N, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Bullock, A.N.
登録日2019-10-18
公開日2019-10-30
最終更新日2024-10-23
実験手法X-RAY DIFFRACTION (2.56 Å)
主引用文献Targeting ALK2: An Open Science Approach to Developing Therapeutics for the Treatment of Diffuse Intrinsic Pontine Glioma.
J.Med.Chem., 63, 2020
6SZM
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BU of 6szm by Molmil
Crystal structure of the ACVR1 (ALK2) kinase in complex with the compound M4K2009
分子名称: 1,2-ETHANEDIOL, 1-[4-[4-methyl-5-(3,4,5-trimethoxyphenyl)pyridin-3-yl]phenyl]piperazine, AMMONIUM ION, ...
著者Adamson, R.J, Williams, E.P, Smil, D, Burgess-Brown, N, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Bullock, A.N.
登録日2019-10-02
公開日2019-10-16
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.42 Å)
主引用文献Leveraging an Open Science Drug Discovery Model to Develop CNS-Penetrant ALK2 Inhibitors for the Treatment of Diffuse Intrinsic Pontine Glioma.
J.Med.Chem., 63, 2020
6SRH
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BU of 6srh by Molmil
Crystal structure of the ACVR1 (ALK2) kinase in complex with the compound M4K2117
分子名称: 1,2-ETHANEDIOL, 4-methyl-3-[4-(1-methylpiperidin-4-yl)phenyl]-5-(3,4,5-trimethoxyphenyl)pyridine, Activin receptor type-1, ...
著者Adamson, R.J, Williams, E.P, Smil, D, Burgess-Brown, N, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Bullock, A.N.
登録日2019-09-05
公開日2019-09-18
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.25 Å)
主引用文献Crystal structure of the ACVR1 (ALK2) kinase in complex with the compound M4K2117
To Be Published
6T8N
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BU of 6t8n by Molmil
Crystal structure of the ACVR1 (ALK2) kinase in complex with the compound M4K3007
分子名称: 1,2-ETHANEDIOL, Activin receptor type I, DIMETHYL SULFOXIDE, ...
著者Adamson, R.J, Williams, E.P, Bonomo, S, Rankin, S, Bacos, D, Rae, A, Cramp, S, Burgess-Brown, N, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Bullock, A.N.
登録日2019-10-24
公開日2019-11-27
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.77 Å)
主引用文献Crystal structure of the ACVR1 (ALK2) kinase in complex with the compound M4K3007
To Be Published
5F72
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BU of 5f72 by Molmil
De novo design and crystallographic validation of antibodies targeting a pre-selected epitope
分子名称: Kelch-like ECH-associated protein 1, Single chain Fv from a Fab
著者Liu, X, Taylor, R.D, Griffin, L, Coker, S, Adams, R, Ceska, T, Shi, J, Lawson, A.D.G, Baker, T.
登録日2015-12-07
公開日2016-12-14
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献De novo design and crystallographic validation of antibodies targeting a pre-selected epitope
To Be Published
4CNI
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BU of 4cni by Molmil
Crystal structure of the Fab portion of Olokizumab in complex with IL- 6
分子名称: INTERLEUKIN-6, OLOKIZUMAB HEAVY CHAIN, FAB PORTION, ...
著者Shaw, S, Bourne, T, Meier, C, Carrington, B, Gelinas, R, Henry, A, Popplewell, A, Adams, R, Baker, T, Rapecki, S, Marshall, D, Neale, H, Lawson, A.
登録日2014-01-22
公開日2014-04-30
最終更新日2024-10-23
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Discovery and Characterization of Olokizumab: A Humanized Antibody Targeting Interleukin-6 and Neutralizing Gp130-Signaling.
Mabs, 6, 2014
7EAD
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BU of 7ead by Molmil
Crystal structure of beta-sheet cytochrome c prime from Thermus thermophilus.
分子名称: Cytochrome_P460 domain-containing protein, HEME C
著者Yoshimi, T, Fujii, S, Oki, H, Igawa, T, Adams, R.H, Ueda, K, Kawahara, K, Ohkubo, T, Hough, A.M, Sambongi, Y.
登録日2021-03-07
公開日2022-03-09
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.74 Å)
主引用文献Crystal structure of thermally stable homodimeric cytochrome c'-beta from Thermus thermophilus.
Acta Crystallogr.,Sect.F, 78, 2022
5L6W
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BU of 5l6w by Molmil
Structure Of the LIMK1-ATPgammaS-CFL1 Complex
分子名称: Cofilin-1, LIM domain kinase 1, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER
著者Salah, E, Mathea, S, Oerum, S, Newman, J.A, Tallant, C, Adamson, R, Canning, P, Beltrami, A, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Knapp, S, Bullock, A.N.
登録日2016-05-31
公開日2016-06-08
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.53 Å)
主引用文献Structure Of the LIMK1-ATPgammaS-CFL1 Complex
To Be Published
5G3Q
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BU of 5g3q by Molmil
Crystal structure of a hypothetical domain in WNK1
分子名称: WNK1
著者Pinkas, D.M, Bufton, J.C, Sanvitale, C.E, Bartual, S.G, Adamson, R.J, Krojer, T, Burgess-Brown, N.A, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Bullock, A.
登録日2016-04-29
公開日2017-05-31
最終更新日2024-05-01
実験手法X-RAY DIFFRACTION (1.613 Å)
主引用文献Crystal Structure of a Hypothetical Domain in Wnk1
To be Published
3L0H
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BU of 3l0h by Molmil
Crystal Structure Analysis of W21A mutant of human GSTA1-1 in complex with S-hexylglutathione
分子名称: Glutathione S-transferase A1, S-HEXYLGLUTATHIONE
著者Fanucchi, S, Achilonu, I.A, Adamson, R.J, Fernandes, M.A, Burke, J.P, Dirr, H.W.
登録日2009-12-10
公開日2010-01-12
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2.13 Å)
主引用文献Stability of the domain interface contributes towards the catalytic function at the H-site of class alpha glutathione transferase A1-1.
Biochim.Biophys.Acta, 1804, 2010
3O3T
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BU of 3o3t by Molmil
Crystal Structure Analysis of M32A mutant of human CLIC1
分子名称: Chloride intracellular channel protein 1
著者Fanucchi, S, Achilonu, I.A, Adamson, R.J, Fernandes, M.A, Stoychev, S, Dirr, H.W.
登録日2010-07-26
公開日2010-08-11
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Crystal Structure Analysis of M32A mutant of human CLIC1
To be Published
5S87
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BU of 5s87 by Molmil
XChem group deposition -- Crystal Structure of human ACVR1 in complex with FM010953a
分子名称: 1,2-ETHANEDIOL, 4-methyl-3-[4-(1-methylpiperidin-4-yl)phenyl]-5-(3,4,5-trimethoxyphenyl)pyridine, Activin receptor type-1, ...
著者Williams, E.P, Adamson, R.J, Smil, D, Krojer, T, Burgess-Brown, N, von Delft, F, Bountra, C, Bullock, A.N.
登録日2020-12-11
公開日2021-06-23
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (1.3 Å)
主引用文献XChem group deposition
To Be Published
5S7V
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XChem group deposition -- Crystal Structure of human ACVR1 in complex with FM010942a
分子名称: 1,2-ETHANEDIOL, 4-methyl-3-[4-(1-methylpiperidin-4-yl)phenyl]-5-(3,4,5-trimethoxyphenyl)pyridine, Activin receptor type-1, ...
著者Williams, E.P, Adamson, R.J, Smil, D, Krojer, T, Burgess-Brown, N, von Delft, F, Bountra, C, Bullock, A.N.
登録日2020-12-11
公開日2021-06-23
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (1.31 Å)
主引用文献XChem group deposition
To Be Published
5S7F
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XChem group deposition -- Crystal Structure of human ACVR1 in complex with FM010935a
分子名称: 1,2-ETHANEDIOL, 4-methyl-3-[4-(1-methylpiperidin-4-yl)phenyl]-5-(3,4,5-trimethoxyphenyl)pyridine, Activin receptor type-1, ...
著者Williams, E.P, Adamson, R.J, Smil, D, Krojer, T, Burgess-Brown, N, von Delft, F, Bountra, C, Bullock, A.N.
登録日2020-12-11
公開日2021-06-23
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (1.31 Å)
主引用文献XChem group deposition
To Be Published
5S7O
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XChem group deposition -- Crystal Structure of human ACVR1 in complex with FM007391c
分子名称: 1,2-ETHANEDIOL, 4-methyl-3-[4-(1-methylpiperidin-4-yl)phenyl]-5-(3,4,5-trimethoxyphenyl)pyridine, Activin receptor type-1, ...
著者Williams, E.P, Adamson, R.J, Smil, D, Krojer, T, Burgess-Brown, N, von Delft, F, Bountra, C, Bullock, A.N.
登録日2020-12-11
公開日2021-06-23
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (1.43 Å)
主引用文献XChem group deposition
To Be Published
5S7R
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XChem group deposition -- Crystal Structure of human ACVR1 in complex with FM010918a
分子名称: 1,2-ETHANEDIOL, 1lambda~6~,2-thiazetidine-1,1-dione, 4-methyl-3-[4-(1-methylpiperidin-4-yl)phenyl]-5-(3,4,5-trimethoxyphenyl)pyridine, ...
著者Williams, E.P, Adamson, R.J, Smil, D, Krojer, T, Burgess-Brown, N, von Delft, F, Bountra, C, Bullock, A.N.
登録日2020-12-11
公開日2021-06-23
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (1.46 Å)
主引用文献XChem group deposition
To Be Published

 

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