5NLB

Crystal structure of human CUL3 N-terminal domain bound to KEAP1 BTB and 3-box

Summary for 5NLB

• Entry DOI: 10.2210/pdb5nlb/pdb
• Descriptor: Kelch-like ECH-associated protein 1, Cullin-3 (2 entities in total)
• Functional Keywords: e3 ubiquitin ligase, ligase
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 58895.46

Authors

Adamson, R.,Krojer, T.,Pinkas, D.M.,Bartual, S.G.,Burgess-Brown, N.A.,Borkowska, O.,Chalk, R.,Newman, J.A.,Kopec, J.,Dixon-Clarke, S.E.,Mathea, S.,Sethi, R.,Velupillai, S.,Mackinnon, S.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Bullock, A. (deposition date: 2017-04-04, release date: 2017-04-19, Last modification date: 2024-01-17)

• Primary citation: Adamson, R.J.,Payne, N.C.,Bartual, S.G.,Mazitschek, R.,Bullock, A.N.; Structural and biochemical characterization establishes a detailed understanding of KEAP1-CUL3 complex assembly.; Free Radic Biol Med, 204:215-225, 2023; PubMed: 37156295; DOI: 10.1016/j.freeradbiomed.2023.04.021

Experimental method

X-RAY DIFFRACTION (3.45 Å)