5PAI
| human factor VIIa in complex with N-(2-amino-1H-benzimidazol-5-yl)-1-[3-[[(3,5-dimethyl-1,2-oxazol-4-yl)carbamoylamino]methyl]phenyl]-5-hydroxypyrazole-4-carboxamide at 1.73A | Descriptor: | CALCIUM ION, CHLORIDE ION, Coagulation factor VII heavy chain, ... | Authors: | Stihle, M, Mayweg, A, Roever, S, Rudolph, M.G. | Deposit date: | 2016-11-10 | Release date: | 2017-06-21 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.73 Å) | Cite: | Crystal Structure of a Factor VIIa complex To be published
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6T06
| Crystal structure of YTHDC1 with fragment 19 (DHU_DC1_045) | Descriptor: | 3-imidazolidin-2-yl-2~{H}-indazole, SULFATE ION, YTHDC1 | Authors: | Bedi, R.K, Huang, D, Sledz, P, Caflisch, A. | Deposit date: | 2019-10-02 | Release date: | 2020-03-04 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Selectively Disrupting m6A-Dependent Protein-RNA Interactions with Fragments. Acs Chem.Biol., 15, 2020
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4P7C
| Crystal structure of putative methyltransferase from Pseudomonas syringae pv. tomato | Descriptor: | 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ACETATE ION, tRNA (mo5U34)-methyltransferase | Authors: | Chang, C, Mack, J, Clancy, S, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) | Deposit date: | 2014-03-26 | Release date: | 2014-04-09 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Crystal structure of putative methyltransferase from Pseudomonas syringae pv. tomato To Be Published
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8V4K
| CCP5 in complex with microtubules class1 | Descriptor: | Cytosolic carboxypeptidase-like protein 5, GLUTAMIC ACID, GUANOSINE-5'-TRIPHOSPHATE, ... | Authors: | Chen, J, Zehr, E.A, Gruschus, J.M, Szyk, A, Liu, Y, Tanner, M.E, Tjandra, N, Roll-Mecak, A. | Deposit date: | 2023-11-29 | Release date: | 2024-07-17 | Last modified: | 2024-10-16 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Tubulin code eraser CCP5 binds branch glutamates by substrate deformation. Nature, 631, 2024
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8UAN
| The crystal structure of cobalt-bound human ADO C18S C239S variant at 1.99 Angstrom | Descriptor: | 2-aminoethanethiol dioxygenase, COBALT (II) ION, GLYCEROL | Authors: | Liu, A, Li, J, Duan, R, Shin, I. | Deposit date: | 2023-09-21 | Release date: | 2024-07-17 | Last modified: | 2024-07-24 | Method: | X-RAY DIFFRACTION (1.99 Å) | Cite: | Cobalt(II)-Substituted Cysteamine Dioxygenase Oxygenation Proceeds through a Cobalt(III)-Superoxo Complex. J.Am.Chem.Soc., 146, 2024
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4YQ7
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8V3O
| CCP5 in complex with Glu-P-peptide 1 transition state analog | Descriptor: | Cytosolic carboxypeptidase-like protein 5, D-MALATE, POTASSIUM ION, ... | Authors: | Chen, J, Zehr, E.A, Gruschus, J.M, Szyk, A, Liu, Y, Tanner, M.E, Tjandra, N, Roll-Mecak, A. | Deposit date: | 2023-11-28 | Release date: | 2024-07-17 | Last modified: | 2024-08-07 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Tubulin code eraser CCP5 binds branch glutamates by substrate deformation. Nature, 631, 2024
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8V4M
| CCP5 in complex with microtubules class3 | Descriptor: | Cytosolic carboxypeptidase-like protein 5, GLUTAMIC ACID, GUANOSINE-5'-TRIPHOSPHATE, ... | Authors: | Chen, J, Zehr, E.A, Gruschus, J.M, Szyk, A, Liu, Y, Tanner, M.E, Tjandra, N, Roll-Mecak, A. | Deposit date: | 2023-11-29 | Release date: | 2024-07-17 | Last modified: | 2024-08-07 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Tubulin code eraser CCP5 binds branch glutamates by substrate deformation. Nature, 631, 2024
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5MED
| Cyanothece lipoxygenase 2 (CspLOX2) | Descriptor: | 1,3-PROPANDIOL, 1,4-BUTANEDIOL, 1-BUTANOL, ... | Authors: | Newie, J, Neumann, P, Werner, M, Mata, R.A, Ficner, R, Feussner, I. | Deposit date: | 2016-11-14 | Release date: | 2017-05-31 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Lipoxygenase 2 from Cyanothece sp. controls dioxygen insertion by steric shielding and substrate fixation. Sci Rep, 7, 2017
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5MEZ
| Crystal structure of Smad4-MH1 bound to the GGCT site. | Descriptor: | CHLORIDE ION, DNA (5'-D(P*GP*CP*AP*GP*GP*CP*TP*AP*GP*CP*CP*TP*GP*CP*A)-3'), MH1 domain of human Smad4, ... | Authors: | Kaczmarska, Z, Freier, R, Marquez, J.A, Macias, M.J. | Deposit date: | 2016-11-16 | Release date: | 2017-11-15 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.98 Å) | Cite: | Structural basis for genome wide recognition of 5-bp GC motifs by SMAD transcription factors. Nat Commun, 8, 2017
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7K48
| Structure of NavAb/Nav1.7-VS2A chimera trapped in the resting state by tarantula toxin m3-Huwentoxin-IV | Descriptor: | Maltose/maltodextrin-binding periplasmic protein,Ion transport protein,Sodium channel protein type 9 subunit alpha chimera, Mu-theraphotoxin-Hs2a | Authors: | Wisedchaisri, G, Tonggu, L, Gamal El-Din, T.M, McCord, E, Zheng, N, Catterall, W.A. | Deposit date: | 2020-09-15 | Release date: | 2020-12-02 | Last modified: | 2021-01-20 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Structural Basis for High-Affinity Trapping of the Na V 1.7 Channel in Its Resting State by Tarantula Toxin. Mol.Cell, 81, 2021
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8UOW
| Structure of atypical asparaginase from Rhodospirillum rubrum (mutant Y21A) | Descriptor: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Asparaginase | Authors: | Lubkowski, J, Wlodawer, A, Zhang, D. | Deposit date: | 2023-10-20 | Release date: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | RrA, an enzyme from Rhodospirillum rubrum, is a prototype of a new family of short-chain L-asparaginases. Protein Sci., 33, 2024
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5T1V
| Crystal structure of Zika virus NS2B-NS3 protease in apo-form. | Descriptor: | NS2B-NS3 protease,NS2B-NS3 protease | Authors: | Nocadello, S, Light, S.H, Minasov, G, Shuvalova, L, Cardona-Correa, A.A, Ojeda, I, Vargas, J, Johnson, M.E, Lee, H, Anderson, W.F, Center for Structural Genomics of Infectious Diseases, Center for Structural Genomics of Infectious Diseases (CSGID) | Deposit date: | 2016-08-22 | Release date: | 2016-09-07 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Crystal structure of Zika virus NS2B-NS3 protease in apo-form. To Be Published
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5MFJ
| Designed armadillo repeat protein YIII(Dq.V2)4CqI in complex with peptide (KR)5 | Descriptor: | (KR)5, YIII(Dq.V2)4CqI | Authors: | Hansen, S, Ernst, P, Reichen, C, Ewald, C, Mittl, P, Plueckthun, A. | Deposit date: | 2016-11-18 | Release date: | 2017-09-13 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.53 Å) | Cite: | Curvature of designed armadillo repeat proteins allows modular peptide binding. J. Struct. Biol., 201, 2018
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6T08
| Crystal structure of YTHDC1 with fragment 21 (DHU_DC1_131) | Descriptor: | SULFATE ION, YTHDC1, ~{N}-(1~{H}-imidazol-2-yl)thiophene-2-sulfonamide | Authors: | Bedi, R.K, Huang, D, Sledz, P, Caflisch, A. | Deposit date: | 2019-10-02 | Release date: | 2020-03-04 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.41 Å) | Cite: | Selectively Disrupting m6A-Dependent Protein-RNA Interactions with Fragments. Acs Chem.Biol., 15, 2020
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6VL4
| Crystal Structure of mPGES-1 bound to DG-031 | Descriptor: | (2R)-cyclopentyl{4-[(quinolin-2-yl)methoxy]phenyl}acetic acid, Prostaglandin E synthase, TETRAETHYLENE GLYCOL, ... | Authors: | Ho, J.D, Lee, M.R, Rauch, C.T, Aznavour, K, Park, J.S, Luz, J.G, Antonysamy, S, Condon, B, Maletic, M, Zhang, A, Hickey, M.J, Hughes, N.E, Chandrasekhar, S, Sloan, A.V, Gooding, K, Harvey, A, Yu, X.P, Kahl, S.D, Norman, B.H. | Deposit date: | 2020-01-22 | Release date: | 2020-12-02 | Last modified: | 2020-12-16 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Structure-based, multi-targeted drug discovery approach to eicosanoid inhibition: Dual inhibitors of mPGES-1 and 5-lipoxygenase activating protein (FLAP). Biochim Biophys Acta Gen Subj, 1865, 2020
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4YTN
| Crystal structure of Mitochondrial rhodoquinol-fumarate reductase from Ascaris suum with N-[3-(pentafluorophenoxy)phenyl]-2-(trifluoromethyl)benzamide | Descriptor: | Cytochrome b-large subunit, FE2/S2 (INORGANIC) CLUSTER, FE3-S4 CLUSTER, ... | Authors: | Harada, S, Shiba, T, Sato, D, Yamamoto, A, Nagahama, M, Yone, A, Inaoka, D.K, Sakamoto, K, Inoue, M, Honma, T, Kita, K. | Deposit date: | 2015-03-18 | Release date: | 2015-08-05 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | New Insights into the Design of Inhibitors Targeted for Parasitic Anaerobic Energy Metabolism To Be Published
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8RGE
| Serial synchrotron in plate room temperature structure of Lysozyme. | Descriptor: | CHLORIDE ION, Lysozyme C, SODIUM ION | Authors: | Thompson, A.J, Hough, M.A, Sanchez-Weatherby, J, Williams, L.J, Sandy, J, Worrall, J.A.R. | Deposit date: | 2023-12-13 | Release date: | 2023-12-27 | Last modified: | 2024-04-17 | Method: | X-RAY DIFFRACTION (1.88 Å) | Cite: | Efficient in situ screening of and data collection from microcrystals in crystallization plates. Acta Crystallogr D Struct Biol, 80, 2024
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7K97
| Human DNA polymerase beta dGDP product complex with Mn2+ | Descriptor: | DNA (5'-D(*CP*CP*GP*AP*CP*CP*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*CP*G)-3'), DNA (5'-D(P*GP*TP*CP*GP*G)-3'), ... | Authors: | Varela, F.A, Freudenthal, B.D. | Deposit date: | 2020-09-28 | Release date: | 2021-02-03 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Mechanism of Deoxyguanosine Diphosphate Insertion by Human DNA Polymerase beta. Biochemistry, 60, 2021
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8R8C
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8UP3
| Structure of atypical asparaginase from Rhodospirillum rubrum (mutant Y21F) | Descriptor: | 1,2-ETHANEDIOL, ASPARTIC ACID, Asparaginase, ... | Authors: | Lubkowski, J, Wlodawer, A, Zhang, D. | Deposit date: | 2023-10-20 | Release date: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.76 Å) | Cite: | RrA, an enzyme from Rhodospirillum rubrum, is a prototype of a new family of short-chain L-asparaginases. Protein Sci., 33, 2024
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5M5Z
| Chaetomium thermophilum beta-1-3-glucanase | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Beta-1,3-glucanase, ... | Authors: | Papageorgiou, A.C, Chen, J, Li, D. | Deposit date: | 2016-10-23 | Release date: | 2017-05-17 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.25 Å) | Cite: | Crystal structure and biological implications of a glycoside hydrolase family 55 beta-1,3-glucanase from Chaetomium thermophilum. Biochim. Biophys. Acta, 1865, 2017
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5KXP
| Hen Egg White Lysozyme at 278K, Data set 2 | Descriptor: | Lysozyme C, SODIUM ION | Authors: | Russi, S, Gonzalez, A, Kenner, L.R, Keedy, D.A, Fraser, J.S, van den Bedem, H. | Deposit date: | 2016-07-20 | Release date: | 2016-09-07 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.2 Å) | Cite: | Conformational variation of proteins at room temperature is not dominated by radiation damage. J Synchrotron Radiat, 24, 2017
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4DQ6
| Crystal structure of PLP-bound putative aminotransferase from Clostridium difficile 630 | Descriptor: | CHLORIDE ION, PYRIDOXAL-5'-PHOSPHATE, Putative pyridoxal phosphate-dependent transferase | Authors: | Shabalin, I.G, Onopriyenko, O, Kudritska, M, Chruszcz, M, Grimshaw, S, Porebski, P.J, Cooper, D.R, Savchenko, A, Anderson, W.F, Minor, W, Center for Structural Genomics of Infectious Diseases (CSGID) | Deposit date: | 2012-02-15 | Release date: | 2012-02-29 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Crystal structures of putative aminotransferase from Clostridium difficile
630 to be published
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5KXY
| Hen Egg White Lysozyme at 278K, Data set 8 | Descriptor: | Lysozyme C, SODIUM ION | Authors: | Russi, S, Gonzalez, A, Kenner, L.R, Keedy, D.A, Fraser, J.S, van den Bedem, H. | Deposit date: | 2016-07-20 | Release date: | 2016-09-07 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.2 Å) | Cite: | Conformational variation of proteins at room temperature is not dominated by radiation damage. J Synchrotron Radiat, 24, 2017
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