6VL4

Crystal Structure of mPGES-1 bound to DG-031

Summary for 6VL4

• Entry DOI: 10.2210/pdb6vl4/pdb
• Descriptor: Prostaglandin E synthase, (2R)-cyclopentyl{4-[(quinolin-2-yl)methoxy]phenyl}acetic acid, octyl beta-D-glucopyranoside, ... (5 entities in total)
• Functional Keywords: mpges-1, membrane protein, isomerase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 18365.81

Authors

Ho, J.D.,Lee, M.R.,Rauch, C.T.,Aznavour, K.,Park, J.S.,Luz, J.G.,Antonysamy, S.,Condon, B.,Maletic, M.,Zhang, A.,Hickey, M.J.,Hughes, N.E.,Chandrasekhar, S.,Sloan, A.V.,Gooding, K.,Harvey, A.,Yu, X.P.,Kahl, S.D.,Norman, B.H. (deposition date: 2020-01-22, release date: 2020-12-02, Last modification date: 2020-12-16)

• Primary citation: Ho, J.D.,Lee, M.R.,Rauch, C.T.,Aznavour, K.,Park, J.S.,Luz, J.G.,Antonysamy, S.,Condon, B.,Maletic, M.,Zhang, A.,Hickey, M.J.,Hughes, N.E.,Chandrasekhar, S.,Sloan, A.V.,Gooding, K.,Harvey, A.,Yu, X.P.,Kahl, S.D.,Norman, B.H.; Structure-based, multi-targeted drug discovery approach to eicosanoid inhibition: Dual inhibitors of mPGES-1 and 5-lipoxygenase activating protein (FLAP).; Biochim Biophys Acta Gen Subj, 1865:129800-129800, 2020; PubMed: 33246032; DOI: 10.1016/j.bbagen.2020.129800

Experimental method

X-RAY DIFFRACTION (1.4 Å)