6DFT
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![BU of 6dft by Molmil](/molmil-images/mine/6dft) | Trypanosoma brucei deoxyhypusine synthase | Descriptor: | Deoxyhypusine synthase, Deoxyhypusine synthase regulatory subunit, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ... | Authors: | Tomchick, D.R, Phillips, M.A, Afanador, G.A. | Deposit date: | 2018-05-15 | Release date: | 2018-08-08 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (3.5 Å) | Cite: | Trypanosomatid Deoxyhypusine Synthase Activity Is Dependent on Shared Active-Site Complementation between Pseudoenzyme Paralogs. Structure, 26, 2018
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6QP3
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![BU of 6qp3 by Molmil](/molmil-images/mine/6qp3) | Crystal structure of the PLP-bound C-S lyase from Bacillus subtilis (strain 168) | Descriptor: | ACETATE ION, Cystathionine beta-lyase PatB, PYRIDOXAL-5'-PHOSPHATE | Authors: | Herman, R, Rudden, M, Wilkinson, A.J, Hanai, S, Thomas, G.H. | Deposit date: | 2019-02-13 | Release date: | 2020-03-04 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | The molecular basis of thioalcohol production in human body odour. Sci Rep, 10, 2020
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8C4Z
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![BU of 8c4z by Molmil](/molmil-images/mine/8c4z) | ProteinT protease, inactive mutant S224A | Descriptor: | CALCIUM ION, Extracellular serine proteinase, GLYCEROL, ... | Authors: | Nomme, J, Gavalda, S, Cioci, G, Guicherd, M, Marty, A, Duquesne, S, Ben Khaled, M. | Deposit date: | 2023-01-05 | Release date: | 2024-07-17 | Last modified: | 2024-08-07 | Method: | X-RAY DIFFRACTION (1.47 Å) | Cite: | An engineered enzyme embedded into PLA to make self-biodegradable plastic. Nature, 631, 2024
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6H7M
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![BU of 6h7m by Molmil](/molmil-images/mine/6h7m) | ACTIVATED TURKEY BETA1 ADRENOCEPTOR WITH BOUND PARTIAL AGONIST SALBUTAMOL AND NANOBODY Nb6B9 | Descriptor: | Beta-1 adrenergic receptor, Camelid antibody fragment Nb6B9, HEGA-10, ... | Authors: | Warne, T, Edwards, P.C, Dore, A.S, Leslie, A.G.W, Tate, C.G. | Deposit date: | 2018-07-31 | Release date: | 2018-10-17 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.76 Å) | Cite: | Molecular basis for high-affinity agonist binding in GPCRs. Science, 364, 2019
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7QK7
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![BU of 7qk7 by Molmil](/molmil-images/mine/7qk7) | Crystal structure of the APO form of ALDH1A3 | Descriptor: | Aldehyde dehydrogenase family 1 member A3, DI(HYDROXYETHYL)ETHER, GLYCEROL | Authors: | Castellvi, A, Farres, J. | Deposit date: | 2021-12-17 | Release date: | 2022-04-20 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.289 Å) | Cite: | Structural and biochemical evidence that ATP inhibits the cancer biomarker human aldehyde dehydrogenase 1A3. Commun Biol, 5, 2022
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7ZII
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![BU of 7zii by Molmil](/molmil-images/mine/7zii) | Crystal structure of human tryptophan hydroxylase 1 in complex with inhibitor KM-05-193 | Descriptor: | 8-(5~{H}-[1,3]dioxolo[4,5-f]benzimidazol-6-ylmethyl)-7-(phenylmethyl)-3-propyl-purine-2,6-dione, FE (III) ION, GLYCEROL, ... | Authors: | Schuetz, A, Mallow, K, Nazare, M, Specker, E, Heinemann, U. | Deposit date: | 2022-04-08 | Release date: | 2022-09-07 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.6280005 Å) | Cite: | Structure-Based Design of Xanthine-Benzimidazole Derivatives as Novel and Potent Tryptophan Hydroxylase Inhibitors. J.Med.Chem., 65, 2022
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7QQL
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![BU of 7qql by Molmil](/molmil-images/mine/7qql) | The PDZ domain of SNTG2 complexed with the phosphorylated PDZ-binding motif of RSK1 | Descriptor: | CALCIUM ION, GLYCEROL, Gamma-2-syntrophin,Annexin A2, ... | Authors: | Cousido-Siah, A, Trave, G, Gogl, G. | Deposit date: | 2022-01-10 | Release date: | 2022-04-20 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.44 Å) | Cite: | A scalable strategy to solve structures of PDZ domains and their complexes. Acta Crystallogr D Struct Biol, 78, 2022
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8CG7
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![BU of 8cg7 by Molmil](/molmil-images/mine/8cg7) | Structure of p53 cancer mutant Y220C with arylation at Cys182 and Cys277 | Descriptor: | 1,2-ETHANEDIOL, 5-iodanyl-2-methylsulfonyl-pyrimidine, Cellular tumor antigen p53, ... | Authors: | Balourdas, D.I, Pichon, M.M, Baud, M.G.J, Knapp, S, Joerger, A.C, Structural Genomics Consortium (SGC) | Deposit date: | 2023-02-03 | Release date: | 2023-12-13 | Last modified: | 2024-07-24 | Method: | X-RAY DIFFRACTION (1.53 Å) | Cite: | Structure-Reactivity Studies of 2-Sulfonylpyrimidines Allow Selective Protein Arylation. Bioconjug.Chem., 34, 2023
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5IJS
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![BU of 5ijs by Molmil](/molmil-images/mine/5ijs) | Crystal structure of autotaxin with orthovanadate bound as a trigonal bipyramidal intermediate analog | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 7alpha-hydroxycholesterol, CALCIUM ION, ... | Authors: | Hausmann, J, Joosten, R.P, Perrakis, A. | Deposit date: | 2016-03-02 | Release date: | 2016-06-15 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structural snapshots of the catalytic cycle of the phosphodiesterase Autotaxin. J.Struct.Biol., 195, 2016
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7ZIJ
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![BU of 7zij by Molmil](/molmil-images/mine/7zij) | Crystal structure of human tryptophan hydroxylase 1 in complex with inhibitor KM-05-080 | Descriptor: | 8-(1~{H}-benzimidazol-2-ylmethyl)-3-cyclopropyl-7-(phenylmethyl)purine-2,6-dione, FE (III) ION, Tryptophan 5-hydroxylase 1 | Authors: | Schuetz, A, Mallow, K, Nazare, M, Specker, E, Heinemann, U. | Deposit date: | 2022-04-08 | Release date: | 2022-09-07 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.94678366 Å) | Cite: | Structure-Based Design of Xanthine-Benzimidazole Derivatives as Novel and Potent Tryptophan Hydroxylase Inhibitors. J.Med.Chem., 65, 2022
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6GIL
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![BU of 6gil by Molmil](/molmil-images/mine/6gil) | NMR structure of temporin B in SDS micelles | Descriptor: | Temporin-B | Authors: | Manzo, G, Mason, J.A. | Deposit date: | 2018-05-12 | Release date: | 2018-06-13 | Last modified: | 2024-06-19 | Method: | SOLUTION NMR | Cite: | Minor sequence modifications in temporin B cause drastic changes in antibacterial potency and selectivity by fundamentally altering membrane activity. Sci Rep, 9, 2019
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6TTX
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![BU of 6ttx by Molmil](/molmil-images/mine/6ttx) | Crystal structure of the human METTL3-METTL14 complex bound to Compound 5 (ASI_M3M_051) | Descriptor: | (2~{S},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)-~{N}-(piperidin-4-ylmethyl)oxolane-2-carboxamide, ACETATE ION, N6-adenosine-methyltransferase catalytic subunit, ... | Authors: | Bedi, R.K, Huang, D, Sledz, P, Caflisch, A. | Deposit date: | 2019-12-30 | Release date: | 2020-03-04 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Small-Molecule Inhibitors of METTL3, the Major Human Epitranscriptomic Writer. Chemmedchem, 15, 2020
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6GS5
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![BU of 6gs5 by Molmil](/molmil-images/mine/6gs5) | NMR structure of temporin L in SDS micelles | Descriptor: | Temporin-L | Authors: | Manzo, G, Mason, J.A. | Deposit date: | 2018-06-13 | Release date: | 2018-07-18 | Last modified: | 2024-06-19 | Method: | SOLUTION NMR | Cite: | Temporin L and aurein 2.5 have identical conformations but subtly distinct membrane and antibacterial activities. Sci Rep, 9, 2019
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7QK8
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![BU of 7qk8 by Molmil](/molmil-images/mine/7qk8) | Crystal structure of the ALDH1A3-NAD+ complex | Descriptor: | Aldehyde dehydrogenase family 1 member A3, DI(HYDROXYETHYL)ETHER, GLYCEROL, ... | Authors: | Castellvi, A, Farres, J. | Deposit date: | 2021-12-17 | Release date: | 2022-04-20 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.893 Å) | Cite: | Structural and biochemical evidence that ATP inhibits the cancer biomarker human aldehyde dehydrogenase 1A3. Commun Biol, 5, 2022
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6DQW
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7ZKR
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![BU of 7zkr by Molmil](/molmil-images/mine/7zkr) | Human GABARAP in complex with stapled peptide Pen3-ortho | Descriptor: | CHLORIDE ION, Gamma-aminobutyric acid receptor-associated protein, ORTHO-XYLENE, ... | Authors: | Ueffing, A, Brown, H, Willbold, D, Kritzer, J.A, Weiergraeber, O.H. | Deposit date: | 2022-04-13 | Release date: | 2022-08-31 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.1 Å) | Cite: | Structure-Based Design of Stapled Peptides That Bind GABARAP and Inhibit Autophagy. J.Am.Chem.Soc., 144, 2022
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7QQN
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![BU of 7qqn by Molmil](/molmil-images/mine/7qqn) | The PDZ domain of SNTG1 complexed with the acetylated PDZ-binding motif of TRPV3 | Descriptor: | CALCIUM ION, GLYCEROL, Gamma-1-syntrophin,Annexin A2, ... | Authors: | Cousido-Siah, A, Trave, G, Gogl, G. | Deposit date: | 2022-01-10 | Release date: | 2022-04-20 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.45 Å) | Cite: | A scalable strategy to solve structures of PDZ domains and their complexes. Acta Crystallogr D Struct Biol, 78, 2022
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6GS9
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![BU of 6gs9 by Molmil](/molmil-images/mine/6gs9) | NMR structure of aurein 2.5 in SDS micelles | Descriptor: | Aurein 2.5 | Authors: | Manzo, G, Mason, J.A. | Deposit date: | 2018-06-13 | Release date: | 2018-07-18 | Last modified: | 2024-06-19 | Method: | SOLUTION NMR | Cite: | Temporin L and aurein 2.5 have identical conformations but subtly distinct membrane and antibacterial activities. Sci Rep, 9, 2019
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5IKO
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![BU of 5iko by Molmil](/molmil-images/mine/5iko) | Crystal structure of human brain glycogen phosphorylase | Descriptor: | Glycogen phosphorylase, brain form, HEXAETHYLENE GLYCOL, ... | Authors: | Mathieu, C, Li de la Sierra-Gallay, I, Xu, X, Haouz, A, Rodrigues-Lima, F. | Deposit date: | 2016-03-03 | Release date: | 2016-07-20 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Insights into Brain Glycogen Metabolism: THE STRUCTURE OF HUMAN BRAIN GLYCOGEN PHOSPHORYLASE. J.Biol.Chem., 291, 2016
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7QK9
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![BU of 7qk9 by Molmil](/molmil-images/mine/7qk9) | Crystal structure of the ALDH1A3-ATP complex | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Aldehyde dehydrogenase family 1 member A3, DI(HYDROXYETHYL)ETHER, ... | Authors: | Castellvi, A, Farres, J. | Deposit date: | 2021-12-17 | Release date: | 2022-04-20 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.782 Å) | Cite: | Structural and biochemical evidence that ATP inhibits the cancer biomarker human aldehyde dehydrogenase 1A3. Commun Biol, 5, 2022
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4X89
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![BU of 4x89 by Molmil](/molmil-images/mine/4x89) | NavMs voltage-gated sodium channal pore and C-terminal domain soaked with Silver nitrate | Descriptor: | HEGA-10, Ion transport protein, PENTAETHYLENE GLYCOL, ... | Authors: | Naylor, C.E, Bagneris, C, Wallace, B.A. | Deposit date: | 2014-12-10 | Release date: | 2016-03-09 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.62 Å) | Cite: | Molecular basis of ion permeability in a voltage-gated sodium channel. Embo J., 35, 2016
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6GIJ
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![BU of 6gij by Molmil](/molmil-images/mine/6gij) | NMR structure of temporin B KKG6A in SDS micelles | Descriptor: | temporinB_KKG6A | Authors: | Manzo, G, Mason, J.A. | Deposit date: | 2018-05-12 | Release date: | 2018-06-13 | Last modified: | 2024-06-19 | Method: | SOLUTION NMR | Cite: | Minor sequence modifications in temporin B cause drastic changes in antibacterial potency and selectivity by fundamentally altering membrane activity. Sci Rep, 9, 2019
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7QIL
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4X8Q
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![BU of 4x8q by Molmil](/molmil-images/mine/4x8q) | X-ray crystal structure of AlkD2 from Streptococcus mutans | Descriptor: | CHLORIDE ION, GLYCEROL, PHOSPHATE ION, ... | Authors: | Mullins, E.A, Shi, R, Eichman, B.F. | Deposit date: | 2014-12-10 | Release date: | 2015-05-27 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.729 Å) | Cite: | A New Family of HEAT-Like Repeat Proteins Lacking a Critical Substrate Recognition Motif Present in Related DNA Glycosylases. Plos One, 10, 2015
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5EWK
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![BU of 5ewk by Molmil](/molmil-images/mine/5ewk) | Scabin toxin from Streptomyces Scabies in complex with inhibitor PJ34 | Descriptor: | N~2~,N~2~-DIMETHYL-N~1~-(6-OXO-5,6-DIHYDROPHENANTHRIDIN-2-YL)GLYCINAMIDE, Putative ADP-Ribosyltransferase Scabin | Authors: | Ravulapalli, R, Lyons, B, Merrill, A.R. | Deposit date: | 2015-11-20 | Release date: | 2016-03-23 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Scabin, a Novel DNA-acting ADP-ribosyltransferase from Streptomyces scabies. J.Biol.Chem., 291, 2016
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