8CG7

Structure of p53 cancer mutant Y220C with arylation at Cys182 and Cys277

Summary for 8CG7

Entry DOI	10.2210/pdb8cg7/pdb
Descriptor	Cellular tumor antigen p53, ZINC ION, 1,2-ETHANEDIOL, ... (4 entities in total)
Functional Keywords	p53 cancer mutation, protein stability, covalent modification, cys-arylation, transcription
Biological source	Homo sapiens (human)
Total number of polymer chains	2
Total formula weight	50006.39
Authors	Balourdas, D.I.,Pichon, M.M.,Baud, M.G.J.,Knapp, S.,Joerger, A.C.,Structural Genomics Consortium (SGC) (deposition date: 2023-02-03, release date: 2023-12-13)
Primary citation	Pichon, M.M.,Drelinkiewicz, D.,Lozano, D.,Moraru, R.,Hayward, L.J.,Jones, M.,McCoy, M.A.,Allstrum-Graves, S.,Balourdas, D.I.,Joerger, A.C.,Whitby, R.J.,Goldup, S.M.,Wells, N.,Langley, G.J.,Herniman, J.M.,Baud, M.G.J. Structure-Reactivity Studies of 2-Sulfonylpyrimidines Allow Selective Protein Arylation. Bioconjug.Chem., 34:1679-1687, 2023 Cited by PubMed: 37657082 DOI: 10.1021/acs.bioconjchem.3c00322 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.53 Å)

Structure validation