8QA9
 
 | | Crystal structure of the RK2 plasmid encoded co-complex of the C-terminally truncated transcriptional repressor protein KorB complexed with the partner repressor protein KorA bound to OA-DNA | | 分子名称: | DNA (5'-D(*TP*GP*TP*TP*TP*AP*GP*CP*TP*AP*AP*AP*CP*A)-3'), SULFATE ION, Transcriptional repressor protein KorB, ... | | 著者 | McLean, T.C, Mundy, J.E.A, Lawson, D.M, Le, T.B.K. | | 登録日 | 2023-08-22 | | 公開日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Crystal structure of the RK2 plasmid encoded co-complex of the C-terminally truncated transcriptional repressor protein KorB complexed with the partner repressor protein KorA bound to OA-DNA
To Be Published
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5XRX
 | | EFK17DA structure in Microgel MAA60 | | 分子名称: | Cathelicidin antimicrobial peptide | | 著者 | Datta, A, Bhunia, A. | | 登録日 | 2017-06-10 | | 公開日 | 2018-04-18 | | 最終更新日 | 2024-05-15 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Conformational Aspects of High Content Packing of Antimicrobial Peptides in Polymer Microgels
ACS Appl Mater Interfaces, 9, 2017
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5SWD
 | | Structure of the adenine riboswitch aptamer domain in an intermediate-bound state | | 分子名称: | ADENINE, MAGNESIUM ION, Vibrio vulnificus strain 93U204 chromosome II, ... | | 著者 | Stagno, J.R, Wang, Y.-X, Liu, Y, Bhandari, Y.R, Conrad, C.E, Nelson, G, Li, C, Wendel, D.R, White, T.A, Barty, A, Tuckey, R.A, Zatsepin, N.A, Grant, T.D, Fromme, P, Tan, K, Ji, X, Spence, J.C.H. | | 登録日 | 2016-08-08 | | 公開日 | 2016-11-23 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Structures of riboswitch RNA reaction states by mix-and-inject XFEL serial crystallography.
Nature, 541, 2017
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7JQL
 | | Crystal structure of the Thermus thermophilus 70S ribosome in complex with Bac7-001, mRNA, and deacylated P-site tRNA at 3.00A resolution | | 分子名称: | 16S Ribosomal RNA, 23S Ribosomal RNA, 30S ribosomal protein S10, ... | | 著者 | Mardirossian, M, Sola, R, Beckert, B, Valencic, E, Collis, D.W.P, Borisek, J, Armas, F, Di Stasi, A, Buchmann, J, Syroegin, E.A, Polikanov, Y.S, Magistrato, A, Hilpert, K, Wilson, D.N, Scocchi, M. | | 登録日 | 2020-08-11 | | 公開日 | 2020-08-26 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Peptide Inhibitors of Bacterial Protein Synthesis with Broad Spectrum and SbmA-Independent Bactericidal Activity against Clinical Pathogens.
J.Med.Chem., 63, 2020
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6H7O
 | | ACTIVATED TURKEY BETA1 ADRENOCEPTOR WITH BOUND WEAK PARTIAL AGONIST CYANOPINDOLOL AND NANOBODY Nb6B9 | | 分子名称: | 4-{[(2S)-3-(tert-butylamino)-2-hydroxypropyl]oxy}-3H-indole-2-carbonitrile, Beta-1 adrenergic receptor, Camelid antibody fragment Nb6B9, ... | | 著者 | Warne, T, Edwards, P.C, Dore, A.S, Leslie, A.G.W, Tate, C.G. | | 登録日 | 2018-07-31 | | 公開日 | 2018-10-17 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Molecular basis for high-affinity agonist binding in GPCRs.
Science, 364, 2019
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8HMR
 | | Crystal Structure of PKM2 mutant L144P | | 分子名称: | 1,2-ETHANEDIOL, 1,6-di-O-phosphono-beta-D-fructofuranose, MAGNESIUM ION, ... | | 著者 | Upadhyay, S, Kumar, A, Patel, A.K. | | 登録日 | 2022-12-05 | | 公開日 | 2023-01-11 | | 最終更新日 | 2024-05-29 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Structural and mechanistic insights into cancer patient-derived mutations in Pyruvate Kinase muscle isoform 2
To Be Published
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6PF0
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8V8M
 | | Switchgrass Chalcone Synthase | | 分子名称: | COENZYME A, Chalcone synthase, NARINGENIN | | 著者 | Lewis, J.A, Kang, C. | | 登録日 | 2023-12-05 | | 公開日 | 2024-05-29 | | 最終更新日 | 2024-07-03 | | 実験手法 | X-RAY DIFFRACTION (1.82 Å) | | 主引用文献 | Structural and Interactional Analysis of the Flavonoid Pathway Proteins: Chalcone Synthase, Chalcone Isomerase and Chalcone Isomerase-like Protein.
Int J Mol Sci, 25, 2024
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6B3B
 | | AprA Methyltransferase 1 - GNAT in complex with Mn2+ , SAM, and Malonate | | 分子名称: | AprA Methyltransferase 1, GLYCEROL, MALONATE ION, ... | | 著者 | Skiba, M.A, Smith, J.L. | | 登録日 | 2017-09-21 | | 公開日 | 2017-11-15 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | | 主引用文献 | A Mononuclear Iron-Dependent Methyltransferase Catalyzes Initial Steps in Assembly of the Apratoxin A Polyketide Starter Unit.
ACS Chem. Biol., 12, 2017
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5D8H
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8UWU
 | | EmrE structure in the proton-bound state (WT/L51I heterodimer) | | 分子名称: | SMR family multidrug efflux protein EmrE | | 著者 | Li, J, Sae Her, A, Besch, A, Ramirez, B, Crames, M, Banigan, J.R, Mueller, C, Marsiglia, W.M, Zhang, Y, Traaseth, N.J. | | 登録日 | 2023-11-08 | | 公開日 | 2024-05-29 | | 最終更新日 | 2024-07-03 | | 実験手法 | SOLID-STATE NMR, SOLUTION NMR | | 主引用文献 | Dynamics underlie the drug recognition mechanism by the efflux transporter EmrE.
Nat Commun, 15, 2024
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6PEZ
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6FI5
 | | Crystal structure of C-terminal modified Tau peptide-hybrid 3.2d with 14-3-3sigma | | 分子名称: | (2~{S})-2-(diphenylmethyl)pyrrolidine, 14-3-3 protein sigma, CHLORIDE ION, ... | | 著者 | Andrei, S.A, Meijer, F.A, Ottmann, C, Milroy, L.G. | | 登録日 | 2018-01-17 | | 公開日 | 2018-05-16 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Inhibition of 14-3-3/Tau by Hybrid Small-Molecule Peptides Operating via Two Different Binding Modes.
ACS Chem Neurosci, 9, 2018
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6H23
 | | Crystal structure of the hClpP Y118A mutant with an activating small molecule | | 分子名称: | 1,2-ETHANEDIOL, ATP-dependent Clp protease proteolytic subunit, mitochondrial, ... | | 著者 | Kick, L.M, Sieber, S.A, Schneider, S. | | 登録日 | 2018-07-13 | | 公開日 | 2018-08-29 | | 最終更新日 | 2024-05-15 | | 実験手法 | X-RAY DIFFRACTION (3.089 Å) | | 主引用文献 | Selective Activation of Human Caseinolytic Protease P (ClpP).
Angew. Chem. Int. Ed. Engl., 57, 2018
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7N1Z
 | | NMR structure of native PnIA | | 分子名称: | Alpha-conotoxin PnIA | | 著者 | Conibear, A.C, Rosengren, K.J, Lee, H.S. | | 登録日 | 2021-05-28 | | 公開日 | 2021-11-17 | | 最終更新日 | 2023-11-15 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Posttranslational modifications of alpha-conotoxins: sulfotyrosine and C-terminal amidation stabilise structures and increase acetylcholine receptor binding.
Rsc Med Chem, 12, 2021
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6YIN
 | | Crystal structure of the first bromodomain of BRD4 in complex with a benzo-diazepine ligand | | 分子名称: | (4~{R})-~{N}-[3-(7-methoxy-3,4-dihydro-2~{H}-quinolin-1-yl)propyl]-4-methyl-2-oxidanylidene-1,3,4,5-tetrahydro-1,5-benzodiazepine-6-carboxamide, Bromodomain-containing protein 4 | | 著者 | Picaud, S, Brand, M, Tobias, K, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Conway, S, Filippakopoulos, P. | | 登録日 | 2020-04-01 | | 公開日 | 2020-04-15 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (1.53 Å) | | 主引用文献 | Crystal structure of the first bromodomain of BRD4 in complex with a benzo-diazepine ligand
To Be Published
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8G7U
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6YIT
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7RRO
 | | Structure of the 48-nm repeat doublet microtubule from bovine tracheal cilia | | 分子名称: | Armadillo repeat containing 4, Chromosome 3 C1orf194 homolog, Cilia and flagella associated protein 161, ... | | 著者 | Gui, M, Anderson, J.R, Botsch, J.J, Meleppattu, S, Singh, S.K, Zhang, Q, Brown, A. | | 登録日 | 2021-08-10 | | 公開日 | 2021-10-27 | | 最終更新日 | 2024-06-05 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | De novo identification of mammalian ciliary motility proteins using cryo-EM.
Cell, 184, 2021
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6H49
 | | A polyamorous repressor: deciphering the evolutionary strategy used by the phage-inducible chromosomal islands to spread in nature. | | 分子名称: | Orf20, SULFATE ION | | 著者 | Ciges-Tomas, J.R, Alite, C, Bowring, J.Z, Donderis, J, Penades, J.R, Marina, A. | | 登録日 | 2018-07-20 | | 公開日 | 2019-08-28 | | 最終更新日 | 2024-05-15 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | The structure of a polygamous repressor reveals how phage-inducible chromosomal islands spread in nature.
Nat Commun, 10, 2019
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6H4D
 | | Crystal structure of RsgA from Pseudomonas aeruginosa | | 分子名称: | GUANOSINE-5'-DIPHOSPHATE, Small ribosomal subunit biogenesis GTPase RsgA, ZINC ION | | 著者 | Rocchio, S, Santorelli, D, Travaglini-Allocatelli, C, Federici, L, Di Matteo, A. | | 登録日 | 2018-07-20 | | 公開日 | 2019-06-26 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Structural and functional investigation of the Small Ribosomal Subunit Biogenesis GTPase A (RsgA) from Pseudomonas aeruginosa.
Febs J., 286, 2019
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7APJ
 | | Structure of autoinhibited Akt1 reveals mechanism of PIP3-mediated activation | | 分子名称: | NB41, RAC-alpha serine/threonine-protein kinase,Non-specific serine/threonine protein kinase,RAC-alpha serine/threonine-protein kinase | | 著者 | Truebestein, L, Hornegger, H, Leonard, T.A. | | 登録日 | 2020-10-16 | | 公開日 | 2021-08-25 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | | 主引用文献 | Structure of autoinhibited Akt1 reveals mechanism of PIP 3 -mediated activation.
Proc.Natl.Acad.Sci.USA, 118, 2021
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7UMB
 | | NanoBRET tracer Tram-bo bound to a KSR2-MEK1 complex | | 分子名称: | Dual specificity mitogen-activated protein kinase kinase 1, Kinase suppressor of Ras 2, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... | | 著者 | Marsiglia, W.M, Khan, K.M, Dar, A.C. | | 登録日 | 2022-04-06 | | 公開日 | 2023-09-27 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (3.231 Å) | | 主引用文献 | Live-cell target engagement of allosteric MEKi on MEK-RAF/KSR-14-3-3 complexes.
Nat.Chem.Biol., 20, 2024
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4RKD
 | | Psychrophilic aromatic amino acids aminotransferase from Psychrobacter sp. B6 cocrystalized with aspartic acid | | 分子名称: | 2-[(3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YLMETHYLENE)-AMINO]-SUCCINIC ACID, 4'-DEOXY-4'-AMINOPYRIDOXAL-5'-PHOSPHATE, Aromatic amino acid aminotransferase, ... | | 著者 | Bujacz, A, Rutkiewicz-Krotewicz, M, Bujacz, G, Nowakowska-Sapota, K, Turkiewicz, M. | | 登録日 | 2014-10-12 | | 公開日 | 2015-03-11 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.76 Å) | | 主引用文献 | Crystal structure and enzymatic properties of a broad substrate-specificity psychrophilic aminotransferase from the Antarctic soil bacterium Psychrobacter sp. B6.
Acta Crystallogr.,Sect.D, 71, 2015
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5XER
 | | TK9 NMR structure in DPC micelle | | 分子名称: | THR-VAL-TYR-VAL-TYR-SER-ARG-VAL-LYS | | 著者 | Ghosh, A, Bhunia, A. | | 登録日 | 2017-04-05 | | 公開日 | 2018-04-18 | | 最終更新日 | 2024-05-15 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structural insights of a self-assembling 9-residue peptide from the C-terminal tail of the SARS corona virus E-protein in DPC and SDS micelles: A combined high and low resolution spectroscopic study.
Biochim Biophys Acta Biomembr, 1860, 2018
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