7JQL
Crystal structure of the Thermus thermophilus 70S ribosome in complex with Bac7-001, mRNA, and deacylated P-site tRNA at 3.00A resolution
This is a non-PDB format compatible entry.
Summary for 7JQL
Entry DOI | 10.2210/pdb7jql/pdb |
Descriptor | 23S Ribosomal RNA, 50S ribosomal protein L14, 50S ribosomal protein L15, ... (60 entities in total) |
Functional Keywords | bactenecin 7; antibiotic; 70s ribosome; x-ray structure; inhibition of translation; peptidyl transferase center; nascent peptide exit tunnel, ribosome |
Biological source | Thermus thermophilus HB8 More |
Total number of polymer chains | 110 |
Total formula weight | 4469975.75 |
Authors | Mardirossian, M.,Sola, R.,Beckert, B.,Valencic, E.,Collis, D.W.P.,Borisek, J.,Armas, F.,Di Stasi, A.,Buchmann, J.,Syroegin, E.A.,Polikanov, Y.S.,Magistrato, A.,Hilpert, K.,Wilson, D.N.,Scocchi, M. (deposition date: 2020-08-11, release date: 2020-08-26, Last modification date: 2023-11-15) |
Primary citation | Mardirossian, M.,Sola, R.,Beckert, B.,Valencic, E.,Collis, D.W.P.,Borisek, J.,Armas, F.,Di Stasi, A.,Buchmann, J.,Syroegin, E.A.,Polikanov, Y.S.,Magistrato, A.,Hilpert, K.,Wilson, D.N.,Scocchi, M. Peptide Inhibitors of Bacterial Protein Synthesis with Broad Spectrum and SbmA-Independent Bactericidal Activity against Clinical Pathogens. J.Med.Chem., 63:9590-9602, 2020 Cited by PubMed: 32787108DOI: 10.1021/acs.jmedchem.0c00665 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3 Å) |
Structure validation
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