6YIN
Crystal structure of the first bromodomain of BRD4 in complex with a benzo-diazepine ligand
Summary for 6YIN
Entry DOI | 10.2210/pdb6yin/pdb |
Descriptor | Bromodomain-containing protein 4, (4~{R})-~{N}-[3-(7-methoxy-3,4-dihydro-2~{H}-quinolin-1-yl)propyl]-4-methyl-2-oxidanylidene-1,3,4,5-tetrahydro-1,5-benzodiazepine-6-carboxamide (3 entities in total) |
Functional Keywords | bromodomain, brd4, small molecule, benzo-diazepine, sgc, structural genomics consortium, transcription |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 15521.90 |
Authors | Picaud, S.,Brand, M.,Tobias, K.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Conway, S.,Filippakopoulos, P. (deposition date: 2020-04-01, release date: 2020-04-15, Last modification date: 2024-01-24) |
Primary citation | Picaud, S.,Brand, M.,Tobias, K.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Conway, S.,Filippakopoulos, P. Crystal structure of the first bromodomain of BRD4 in complex with a benzo-diazepine ligand To Be Published, |
Experimental method | X-RAY DIFFRACTION (1.53 Å) |
Structure validation
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