7BRZ
| Bovine Pancreatic Trypsin with 2-Methyltryptamine (Room Temperature) | 分子名称: | 2-(2-methyl-1H-indol-3-yl)ethanamine, CALCIUM ION, Cationic trypsin, ... | 著者 | Maeki, M, Ito, S, Takeda, R, Funakubo, T, Ueno, G, Ishida, A, Tani, H, Yamamoto, M, Tokeshi, M. | 登録日 | 2020-03-30 | 公開日 | 2020-08-26 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | 主引用文献 | Room-temperature crystallography using a microfluidic protein crystal array device and its application to protein-ligand complex structure analysis. Chem Sci, 11, 2020
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8A43
| Human RNA polymerase I | 分子名称: | DNA-directed RNA polymerase I subunit RPA1, DNA-directed RNA polymerase I subunit RPA12, DNA-directed RNA polymerase I subunit RPA2, ... | 著者 | Daiss, J.L, Pilsl, M, Straub, K, Bleckmann, A, Hoecherl, M, Heiss, F.B, Abascal-Palacios, G, Ramsay, E, Tluckova, K, Mars, J.C, Fuertges, T, Bruckmann, A, Rudack, T, Bernecky, C, Lamour, V, Panov, K, Vannini, A, Moss, T, Engel, C. | 登録日 | 2022-06-10 | 公開日 | 2022-08-31 | 最終更新日 | 2022-11-02 | 実験手法 | ELECTRON MICROSCOPY (4.09 Å) | 主引用文献 | The human RNA polymerase I structure reveals an HMG-like docking domain specific to metazoans. Life Sci Alliance, 5, 2022
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6FLY
| Structure of AcmJRL, a mannose binding jacalin related lectin from Ananas comosus, in complex with mannose. | 分子名称: | Jacalin-like lectin, alpha-D-mannopyranose | 著者 | Azarkan, M, Herman, R, El Mahyaoui, R, Sauvage, E, Vanden Broeck, A, Charlier, P. | 登録日 | 2018-01-29 | 公開日 | 2018-08-15 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.749 Å) | 主引用文献 | Biochemical and structural characterization of a mannose binding jacalin-related lectin with two-sugar binding sites from pineapple (Ananas comosus) stem. Sci Rep, 8, 2018
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6VC0
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6QU9
| Fab fragment of an antibody that inhibits polymerisation of alpha-1-antitrypsin | 分子名称: | FAB 4B12 heavy chain, FAB 4B12 light chain, GLYCEROL, ... | 著者 | Jagger, A.M, Heyer-Chauhan, N, Lomas, D.A, Irving, J.A. | 登録日 | 2019-02-26 | 公開日 | 2020-03-18 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | The structural basis for Z alpha 1 -antitrypsin polymerization in the liver. Sci Adv, 6, 2020
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5KHT
| Crystal structure of the N-terminal fragment of tropomyosin isoform Tpm1.1 at 1.5 A resolution | 分子名称: | DI(HYDROXYETHYL)ETHER, Tropomyosin alpha-1 chain,General control protein GCN4 | 著者 | Kostyukova, A.S, Krieger, I, Yoon, Y.-H, Tolkatchev, D, Samatey, F.A. | 登録日 | 2016-06-15 | 公開日 | 2017-06-21 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (1.4964 Å) | 主引用文献 | Structural destabilization of tropomyosin induced by the cardiomyopathy-linked mutation R21H. Protein Sci., 27, 2018
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6V9T
| Tudor domain of TDRD3 in complex with a small molecule | 分子名称: | 4-methyl-2,3,4,5,6,7-hexahydrodicyclopenta[b,e]pyridin-8(1H)-imine, Tudor domain-containing protein 3, UNKNOWN ATOM OR ION | 著者 | Li, W, Tempel, W, Arrowsmith, C.H, Bountra, C, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) | 登録日 | 2019-12-16 | 公開日 | 2019-12-25 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.154 Å) | 主引用文献 | A small molecule antagonist of SMN disrupts the interaction between SMN and RNAP II. Nat Commun, 13, 2022
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6FN8
| Domain II of the HUMAN COPPER CHAPERONE FOR SUPEROXIDE DISMUTASE at 1.55 A resolution | 分子名称: | Copper chaperone for superoxide dismutase, ZINC ION | 著者 | Sala, F.A, Wright, G.S.A, Antonyuk, S.V, Garratt, R.C, Hasnain, S.S. | 登録日 | 2018-02-02 | 公開日 | 2019-01-30 | 最終更新日 | 2019-06-19 | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | 主引用文献 | Molecular recognition and maturation of SOD1 by its evolutionarily destabilised cognate chaperone hCCS. Plos Biol., 17, 2019
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5KI4
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6FNW
| Structure of a volume-regulated anion channel of the LRRC8 family | 分子名称: | 1,2-ETHANEDIOL, Volume-regulated anion channel subunit LRRC8A | 著者 | Deneka, D, Sawicka, M, Lam, A.K.M, Paulino, C, Dutzler, R. | 登録日 | 2018-02-05 | 公開日 | 2018-05-16 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Structure of a volume-regulated anion channel of the LRRC8 family. Nature, 558, 2018
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6G2J
| Mouse mitochondrial complex I in the active state | 分子名称: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE, ADENOSINE-5'-DIPHOSPHATE, ... | 著者 | Agip, A.N.A, Blaza, J.N, Bridges, H.R, Viscomi, C, Rawson, S, Muench, S.P, Hirst, J. | 登録日 | 2018-03-23 | 公開日 | 2018-06-06 | 最終更新日 | 2021-06-02 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Cryo-EM structures of complex I from mouse heart mitochondria in two biochemically defined states. Nat. Struct. Mol. Biol., 25, 2018
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5JPA
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6QVY
| The Transcriptional Regulator PrfA-A94V mutant from Listeria Monocytogenes | 分子名称: | ISOPROPYL ALCOHOL, Listeriolysin regulatory protein, SODIUM ION | 著者 | Hall, M, Grundstrom, C, Hansen, S, Brannstrom, K, Johansson, J, Sauer-Eriksson, A.E. | 登録日 | 2019-03-05 | 公開日 | 2020-04-01 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.686 Å) | 主引用文献 | A Novel Growth-Based Selection Strategy Identifies New Constitutively Active Variants of the Major Virulence Regulator PrfA in Listeria monocytogenes. J.Bacteriol., 202, 2020
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6C0R
| Crystal structure of HIV-1 K103N/Y181C mutant reverse transcriptase in complex with non-nucleoside inhibitor 25a | 分子名称: | 1,2-ETHANEDIOL, 4-({4-[(4-{4-[(E)-2-cyanoethenyl]-2,6-dimethylphenoxy}thieno[3,2-d]pyrimidin-2-yl)amino]piperidin-1-yl}methyl)benzene-1-sulfonamide, DIMETHYL SULFOXIDE, ... | 著者 | Yang, Y, Nguyen, L.A, Smithline, Z.B, Steitz, T.A. | 登録日 | 2018-01-02 | 公開日 | 2018-08-01 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.049 Å) | 主引用文献 | Structural basis for potent and broad inhibition of HIV-1 RT by thiophene[3,2-d]pyrimidine non-nucleoside inhibitors. Elife, 7, 2018
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5K53
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7ZM9
| Ketosynthase domain 3 of Brevibacillus Brevis orphan BGC11 | 分子名称: | DI(HYDROXYETHYL)ETHER, GLYCEROL, Putative polyketide synthase | 著者 | Tittes, Y.U, Herbst, D.A, Jakob, R.P, Maier, T. | 登録日 | 2022-04-19 | 公開日 | 2022-09-21 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (1.62 Å) | 主引用文献 | The structure of a polyketide synthase bimodule core. Sci Adv, 8, 2022
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6FQB
| MurT/GatD peptidoglycan amidotransferase complex from Streptococcus pneumoniae R6 | 分子名称: | Cobyric acid synthase, GLUTAMINE, Mur ligase family protein | 著者 | Morlot, C, Contreras-Martel, C, Leisico, F, Straume, D, Peters, K, Hegnar, O.A, Simon, N, Villard, A.M, Breukink, E, Gravier-Pelletier, C, Le Corre, L, Vollmer, W, Pietrancosta, N, Havarstein, L.S, Zapun, A. | 登録日 | 2018-02-13 | 公開日 | 2018-08-22 | 最終更新日 | 2018-11-07 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Structure of the essential peptidoglycan amidotransferase MurT/GatD complex from Streptococcus pneumoniae. Nat Commun, 9, 2018
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4YLU
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6QMO
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8UFO
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6C27
| SAM-III riboswitch ON-state | 分子名称: | COBALT HEXAMMINE(III), SAM-III riboswitch | 著者 | Grigg, J.C, Price, I.R, Ke, A. | 登録日 | 2018-01-07 | 公開日 | 2019-01-09 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (3.601 Å) | 主引用文献 | Evidence for two-tiered conformation selection in the SAM-III riboswitch To Be Published
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4YBZ
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7ZJP
| Optimization of TEAD P-Site Binding Fragment Hit into In Vivo Active Lead MSC-4106 | 分子名称: | 2-methyl-4-[4-(trifluoromethyl)phenyl]pyrazolo[3,4-b]indole-7-carboxylic acid, SULFATE ION, Transcriptional enhancer factor TEF-1 | 著者 | Freire, F, Heinrich, T, Petersson, C, Schneider, R, Garg, S, Schwarz, D, Gunera, J, Seshire, A, Koetzner, L, Schlesiger, S, Musil, D, Schilke, H, Doerfel, B, Diehl, P, Boepple, P, Lemos, A.R, Sousa, P.M.F, Freire, F, Bandeiras, T.M, Carswell, E, Pearson, N, Sirohi, S, Hooker, M, Trivier, E, Broome, R, Balsiger, A, Crowden, A, Dillon, C, Wienke, D. | 登録日 | 2022-04-11 | 公開日 | 2022-07-13 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.19 Å) | 主引用文献 | Optimization of TEAD P-Site Binding Fragment Hit into In Vivo Active Lead MSC-4106 . J.Med.Chem., 65, 2022
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7TD8
| Integrin alaphIIBbeta3 complex with Tirofiban | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | 著者 | Zhu, J, Lin, F.-Y, Zhu, J, Springer, T.A. | 登録日 | 2021-12-30 | 公開日 | 2022-08-17 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | A general chemical principle for creating closure-stabilizing integrin inhibitors. Cell, 185, 2022
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7BNO
| Open conformation of D614G SARS-CoV-2 spike with 2 Erect RBDs | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein | 著者 | Benton, D.J, Wrobel, A.G, Rosenthal, P.B, Gamblin, S.J. | 登録日 | 2021-01-22 | 公開日 | 2021-02-03 | 最終更新日 | 2021-03-10 | 実験手法 | ELECTRON MICROSCOPY (4.2 Å) | 主引用文献 | The effect of the D614G substitution on the structure of the spike glycoprotein of SARS-CoV-2. Proc.Natl.Acad.Sci.USA, 118, 2021
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