4YLU
X-ray structure of MERS-CoV nsp5 protease bound with a non-covalent inhibitor
Summary for 4YLU
Entry DOI | 10.2210/pdb4ylu/pdb |
Related | 4RSP |
Descriptor | ORF1a protein, N-{4-[(1H-benzotriazol-1-ylacetyl)(thiophen-3-ylmethyl)amino]phenyl}propanamide, ACETATE ION, ... (4 entities in total) |
Functional Keywords | protease, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Middle East respiratory syndrome coronavirus |
Total number of polymer chains | 4 |
Total formula weight | 135448.95 |
Authors | Tomar, S.,Mesecar, A.D. (deposition date: 2015-03-05, release date: 2015-06-17, Last modification date: 2024-02-28) |
Primary citation | Tomar, S.,Johnston, M.L.,St John, S.E.,Osswald, H.L.,Nyalapatla, P.R.,Paul, L.N.,Ghosh, A.K.,Denison, M.R.,Mesecar, A.D. Ligand-induced Dimerization of Middle East Respiratory Syndrome (MERS) Coronavirus nsp5 Protease (3CLpro): IMPLICATIONS FOR nsp5 REGULATION AND THE DEVELOPMENT OF ANTIVIRALS. J.Biol.Chem., 290:19403-19422, 2015 Cited by PubMed: 26055715DOI: 10.1074/jbc.M115.651463 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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