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4RSP

X-ray structure of MERS-CoV nsp5 protease bound with a designed inhibitor

Summary for 4RSP
Entry DOI10.2210/pdb4rsp/pdb
Related PRD IDPRD_002174
DescriptorOrf1a protein, Peptide inhibitor (3 entities in total)
Functional Keywordsprotease, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceMiddle East respiratory syndrome coronavirus
More
Cellular locationHost cytoplasm, host perinuclear region . Host membrane ; Multi-pass membrane protein : V9TU12
Total number of polymer chains2
Total formula weight33997.94
Authors
Tomar, S.,Mesecar, A.D. (deposition date: 2014-11-10, release date: 2015-06-17, Last modification date: 2023-12-06)
Primary citationTomar, S.,Johnston, M.L.,St John, S.E.,Osswald, H.L.,Nyalapatla, P.R.,Paul, L.N.,Ghosh, A.K.,Denison, M.R.,Mesecar, A.D.
Ligand-induced Dimerization of Middle East Respiratory Syndrome (MERS) Coronavirus nsp5 Protease (3CLpro): IMPLICATIONS FOR nsp5 REGULATION AND THE DEVELOPMENT OF ANTIVIRALS.
J.Biol.Chem., 290:19403-19422, 2015
Cited by
PubMed: 26055715
DOI: 10.1074/jbc.M115.651463
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.62 Å)
Structure validation

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