4YLU

X-ray structure of MERS-CoV nsp5 protease bound with a non-covalent inhibitor

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0008233	molecular_function	peptidase activity
A	0019082	biological_process	viral protein processing
B	0008233	molecular_function	peptidase activity
B	0019082	biological_process	viral protein processing
C	0008233	molecular_function	peptidase activity
C	0019082	biological_process	viral protein processing
D	0008233	molecular_function	peptidase activity
D	0019082	biological_process	viral protein processing

Functional Information from PDB Data

site_id	AC1
Number of Residues	12
Details	binding site for residue R30 A 401

Chain	Residue
A	HIS41
A	GLN192
A	HOH547
B	SER1
A	LEU49
A	PHE143
A	CYS148
A	HIS166
A	MET168
A	GLU169
A	ASP190
A	LYS191

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site_id	AC2
Number of Residues	2
Details	binding site for residue ACT A 402

Chain	Residue
A	THR108
A	ASP181

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site_id	AC3
Number of Residues	1
Details	binding site for residue ACT A 403

Chain	Residue
A	ASP200

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site_id	AC4
Number of Residues	12
Details	binding site for residue R30 B 401

Chain	Residue
A	HIS64
B	MET25
B	HIS41
B	LEU49
B	PHE143
B	CYS148
B	HIS166
B	MET168
B	GLU169
B	ASP190
B	LYS191
B	HOH674

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site_id	AC5
Number of Residues	2
Details	binding site for residue ACT B 402

Chain	Residue
B	ASP200
B	HOH613

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site_id	AC6
Number of Residues	12
Details	binding site for residue R30 C 401

Chain	Residue
C	MET25
C	LEU49
C	PHE143
C	LEU144
C	CYS148
C	HIS166
C	MET168
C	GLU169
C	ASP190
C	LYS191
C	GLN192
D	SER1

---

site_id	AC7
Number of Residues	1
Details	binding site for residue ACT C 402

Chain	Residue
C	ASP200

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site_id	AC8
Number of Residues	16
Details	binding site for residue R30 D 401

Chain	Residue
D	MET25
D	HIS41
D	CYS44
D	ALA46
D	TYR54
D	PHE143
D	LEU144
D	CYS145
D	CYS148
D	HIS166
D	MET168
D	GLU169
D	ASP190
D	LYS191
D	GLN192
D	HOH540

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site_id	AC9
Number of Residues	1
Details	binding site for residue ACT D 402

Chain	Residue
D	ASP200

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